Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Afaf H. El-Sagheer, Ivanhoe K. H. Leung, Tom Brown, Michael A. McDonough, Anthony Tumber, Nok Yin Tam, Caitlin Clunie-O'Connor, Dong Zhang, Marina Demetriades, Shifali Shishodia, Wei Shen Aik, Thomas M. Leissing, Eidarus Salah, Pratheesh Maheswaran, Yi Min Ng, Christopher J. Schofield
Publikováno v:
Journal of Medicinal Chemistry
FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information from crystal structures of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639c2be01f207a01903964a703615f30
https://ora.ox.ac.uk/objects/uuid:839b007e-dd4b-4bc0-ac22-ed37a4bd5169
https://ora.ox.ac.uk/objects/uuid:839b007e-dd4b-4bc0-ac22-ed37a4bd5169
Publikováno v:
Chemistry & Biology. 16(6):580-583
Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic reg
Autor:
Eleanor A.L. Bagg, Vasilij Koshkin, Sergey N. Krylov, Svetlana M. Krylova, Christopher J. Schofield
Publikováno v:
Journal of medicinal chemistry. 55(7)
The Escherichia coli (E. coli) AlkB protein and its functional human homologues belong to a subfamily of 2-oxoglutarate (2OG) dependent oxygenases (2OG oxygenases for simplicity) that enable the repair of cytotoxic methylation damage in nucleic acids
Autor:
David W. Wegman, Michael A. McDonough, Dack Kevin Neil, Marina Demetriades, Sergey N. Krylov, Louise J. Walport, Eleanor A.L. Bagg, Mun Chiang Chan, Jerome Ma, Svetlana M. Krylova, Wei Shen Aik, Esther C. Y. Woon, Christopher J. Schofield
Publikováno v:
Journal of Medicinal Chemistry
2-Oxoglutarate-dependent nucleic acid demethylases are of biological interest because of their roles in nucleic acid repair and modification. Although some of these enzymes are linked to physiology, their regulatory roles are unclear. Hence, there is
Publikováno v:
Trends in biochemical sciences. 36(1)
Pioneering work in the 1960s defined prolyl and lysyl hydroxylations as physiologically important oxygenase-catalyzed modifications in collagen biosynthesis; subsequent studies demonstrated that extracellular epidermal growth factor-like domains were
Autor:
Anna A. Karkhanina, Michael U. Musheev, Eleanor A.L. Bagg, Sergey N. Krylov, Christopher J. Schofield, Svetlana M. Krylova
Publikováno v:
Analytical Biochemistry.
The AlkB family of oxygenases catalyze the removal of alkyl groups from nucleic acid substrates in an iron and 2-oxoglutarate-dependent manner and have roles including in DNA repair. To understand the biological functions of these DNA-dealkylating en
Autor:
Kirsty S. Hewitson, Anthony P. Coll, Inês Barroso, Christophe Girard, Xavier Prieur, I. Sadaf Farooqi, Thomas Gerken, Christopher J. Schofield, Patrik Rorsman, Sharon Cunliffe, Peter Robins, Barbara Sedgwick, Frances M. Ashcroft, Juris Galvanovskis, Chris P. Ponting, Zorica Jovanovic, Michael A. McDonough, Vladimir Saudek, Marcella Ma, Luke A. McNeill, Celia J. Webby, Tomas Lindahl, Stephen O'Rahilly, Giles S.H. Yeo, Yi-Chun Loraine Tung
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2007, 318 (5855), pp.1469-1472. ⟨10.1126/science.1151710⟩
Science, American Association for the Advancement of Science, 2007, 318 (5855), pp.1469-1472. ⟨10.1126/science.1151710⟩
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate–dependent oxygenases. We fi