Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pablo Helguera"'
Autor:
Pablo Helguera, Orlando V. Billoni, Sergio A. Cannas, Nahuel Zamponi, Dante R. Chialvo, Emiliano Zamponi
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Mitochondrial networks exhibit a variety of complex behaviors, including coordinated cell-wide oscillations of energy states as well as a phase transition (depolarization) in response to oxidative stress. Since functional and structural properties ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4c170ea0efcdbf96f1c656ea140dc5
http://www.nature.com/articles/s41598-017-18351-5
http://www.nature.com/articles/s41598-017-18351-5
Autor:
Emiliano Zamponi, Pablo Helguera
Publikováno v:
Developmental neurobiologyREFERENCES. 79(7)
Oxidative stress (OS) and mitochondrial dysfunction (MD) have been extensively studied and defined as therapeutic targets in Down syndrome (DS). Though originally associated to individual genes located in supernumerary chromosome 21, OS and MD metabo
Autor:
Pinar Coskun, Sergio A. Cannas, Emiliano Zamponi, Nahuel Zamponi, Pablo Helguera, Alfredo Lorenzo, Jorge Busciglio, Gonzalo Quassollo, Katheleen Gardiner, Gustavo Pigino, Dante R. Chialvo
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Zamponi, Emiliano; Zamponi, Nahuel; Coskun, Pinar; Quassollo, Gonzalo; Lorenzo, Alfredo; Cannas, Sergio A; et al.(2018). Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells.. Aging Cell, 17(5), e12812. doi: 10.1111/acel.12812. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8m88h0wf
Aging Cell
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Zamponi, Emiliano; Zamponi, Nahuel; Coskun, Pinar; Quassollo, Gonzalo; Lorenzo, Alfredo; Cannas, Sergio A; et al.(2018). Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells.. Aging Cell, 17(5), e12812. doi: 10.1111/acel.12812. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8m88h0wf
Aging Cell
Mounting evidence implicates chronic oxidative stress as a critical driver of the aging process. Down syndrome (DS) is characterized by a complex phenotype, including early senescence. DS cells display increased levels of reactive oxygen species (ROS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b894ecceb0cb89ba5e91dc15fc467058
Wiley Online Library
Wiley Online Library
Autor:
Yuyu Song, Hector Hugo Caicedo, Fiamma Buratti, Emiliano Zamponi, Lisa Jungbauer, Scott T. Brady, Mariano Bisbal, Gabriel Enrique Cataldi, Jiyan Ma, Alfredo Lorenzo, Pablo Helguera, Gerardo Morfini, Gustavo Pigino, Mary Jo LaDu
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188340 (2017)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE
Prion diseases include a number of progressive neuropathies involving conformational changes in cellular prion protein (PrPc) that may be fatal sporadic, familial or infectious. Pathological evidence indicated that neurons affected in prion diseases
Autor:
Jorge Busciglio, Ryan C. Bohannan, Pablo Helguera, Jean Thomas, Eric Doran, Schriner E. Samuel, Jocelyn Argueta, Zahra Nemati, Pinar Coskun, Douglas C. Wallace, Ira T. Lott
Deficits in mitochondrial function and oxidative stress play pivotal roles in Down syndrome (DS) and Alzheimer's disease (AD) and these alterations in mitochondria occur systemically in both conditions. Objective: We hypothesized that peripheral cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2171022e7666a0906d14bb572d2c6820
https://www.ncbi.nlm.nih.gov/pubmed/27802222
https://www.ncbi.nlm.nih.gov/pubmed/27802222
Autor:
Jorge Busciglio, Pablo Helguera, Elizabeth Head, Alejandra Pelsman, Ernst J. Wolvetang, Gustavo Pigino
Publikováno v:
The Journal of Neuroscience. 25:2295-2303
Down's syndrome (DS) is characterized by mental retardation and development of Alzheimer's disease (AD). Oxidative stress and mitochondrial dysfunction are both related to neurodegeneration in DS. Several genes in chromosome 21 have been linked to ne
Autor:
Pablo Helguera, Jose A. Rodriguez, Michael G. Hanna, Jaqueline Seiglie, Gustavo Helguera, Jorge Busciglio
Publikováno v:
Helguera, P; Seiglie, J; Rodriguez, J; Hanna, M; Helguera, G; & Busciglio, J. (2013). Adaptive Downregulation of Mitochondrial Function in Down Syndrome. CELL METABOLISM, 17(1), 132-140. doi: 10.1016/j.cmet.2012.12.005. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/77m6v7qp
Mitochondrial dysfunction and oxidative stress are common features of Down syndrome (DS). However, the underlying mechanisms are not known. We investigated the relationship between abnormal energy metabolism and oxidative stress with transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8d70af8a1b2926aa7fa819d718aab0
http://www.sciencedirect.com/science/article/pii/S1550413112004962#
http://www.sciencedirect.com/science/article/pii/S1550413112004962#