Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Neil H. Segal"'
Autor:
Kaitlin A. Tkachuk, Leonard B. Saltz, Neil H. Segal, Andrea Cercek, Kenneth Offit, Rona Yaeger, Michael F. Berger, Jinru Shia, Garrett M. Nash, Zalak Patel, Diane Reidy-Lagunes, Rania Sheikh, Jaclyn F. Hechtman, Zsofia K. Stadler, Louise Catherine Connell, Alicia Latham, Martin R. Weiser, Karuna Ganesh, Ahmet Zehir, Julio Garcia-Aguilar, David P. Kelsen, Diana Mandelker, Arnold J. Markowitz, Philip B. Paty, Nancy E. Kemeny
Publikováno v:
Clin Cancer Res
Purpose: The prevalence and clinical characteristics of small bowel adenocarcinomas (SBA) in the setting of Lynch syndrome have not been well studied. We characterized SBA according to DNA mismatch repair and/or microsatellite instability (MMR/MSI) a
Autor:
Jaclyn F. Hechtman, Efsevia Vakiani, Monika Vyas, David S. Klimstra, Canan Firat, Avani Desai, Jinru Shia, Lik Hang Lee, Karuna Ganesh, Zsofia K. Stadler, Peter Ntiamoah, Liying Zhang, Arnold J. Markowitz, Martin R. Weiser, Neil H. Segal, Tao Wang
Publikováno v:
Modern Pathology. 32:1551-1562
Double somatic mismatch-repair-gene mutation/alteration is a recently recognized molecular mechanism that underlies microsatellite instability-high in some colorectal carcinomas. It remains to be determined whether and how microsatellite instability-
Autor:
Zsofia K. Stadler, Philip B. Paty, Lajhem Cambridge, Neil H. Segal, Jose G. Guillem, Julio Garcia-Aguilar, S.Y. Ng, Leonard B. Saltz, Garrett M. Nash, Kathryn L. Colborn, Martin R. Weiser, Karyn A. Goodman, Andrea Cercek, Diane Reidy-Lagunes
Publikováno v:
Clin Colorectal Cancer
Initial treatment with either neoadjuvant chemoradiation (CRT) or induction FOLFOX (5-Fluorouracil, leucovorin, and oxaliplatin) chemotherapy followed by CRT is considered standard treatment for locally advanced rectal cancer. We compared patient-rep
Autor:
Jinru Shia, Ritika Kundra, Marinela Capanu, Jaclyn F. Hechtman, Leonard B. Saltz, Zsofia K. Stadler, Andrea Cercek, Walid K. Chatila, Rona Yaeger, David D. B. Bates, Anna M. Varghese, Nikolaus Schultz, Sebastian Mondaca, Neil H. Segal
Publikováno v:
Clinical Colorectal Cancer. 18:e39-e52
Background Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. We examined the safety and ef
Autor:
Joanne F. Chou, Anna M. Varghese, Pallavi Vedantam, Andrea Cercek, Andreas Rimner, Karuna Ganesh, Travis J. Hollmann, Nancy E. Kemeny, Joseph P. Erinjeri, Yoshiya Yamada, Paul B. Romesser, Diane Reidy-Lagunes, Efsevia Vakiani, Aliya Holland, Neil H. Segal, T. Jonathan Yang, Geoffrey Y. Ku, Abraham J. Wu, Mark L. Solter, Martinique Ogle, Martin R. Weiser, Kathleen C. McAuliffe, Christopher H. Crane, Phillip Wong, Stephen B. Solomon, Danny N. Khalil, John J. Cuaron, Louise Catherine Connell, Marinela Capanu, Krishna Juluru, Taha Merghoub, Leonard B. Saltz, Zsofia K. Stadler, Rona Yaeger, Pamela Vaiskauskas, Ghassan K. Abou-Alfa, David Faleck, Matthew Adamow
Publikováno v:
Clin Cancer Res
Purpose:Immune checkpoint inhibition (ICI) alone is not active in mismatch repair–proficient (MMR-P) metastatic colorectal cancer (mCRC), nor does radiotherapy alone result in objective systemic benefit. However, combined radiotherapy plus ICI can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84496b65de242638490fa7cc0faf7d5e
https://europepmc.org/articles/PMC8499477/
https://europepmc.org/articles/PMC8499477/
Autor:
Martin R. Weiser, Ajaratu Keshinro, Zsofia K. Stadler, William C. Chapman, J. Joshua Smith, Emmanouil P. Pappou, Efsevia Vakiani, Iris H Wei, Tsuyoshi Konishi, Garrett M. Nash, Andrea Cercek, Maria Widmar, Philip B. Paty, Julio Garcia-Aguilar, Yoshifumi Shimada, Meier Hsu, Mithat Gonen, Iván González, Philip S. Bauer, Jinru Shia, Leonard B. Saltz, Neil H. Segal, Deepak Lingam, Rona Yaeger, Matthew G. Mutch, Deyali Chatterjee, Anna M. Varghese
Publikováno v:
J Clin Oncol
PURPOSE Clinical calculators and nomograms have been endorsed by the American Joint Committee on Cancer (AJCC), as they provide the most individualized and accurate estimate of patient outcome. Using molecular and clinicopathologic variables, a third
Autor:
Ajaratu, Keshinro, Chad, Vanderbilt, Jin K, Kim, Canan, Firat, Chin-Tung, Chen, Rona, Yaeger, Karuna, Ganesh, Neil H, Segal, Mithat, Gonen, Jinru, Shia, Zsofia, Stadler, Martin R, Weiser
Publikováno v:
JCO Precis Oncol
To characterize the relationship between tumor-infiltrating lymphocytes (TIL), tumor mutational burden (TMB), and genetic alterations in microsatellite stable (MSS), microsatellite instability (MSI), or mutant POLE/POLD1 colon cancer. MATERIALS AND M
Autor:
Neil H. Segal, David M. Hyman, Katherine Kargus, Alison M. Schram, Jessica Flynn, Komal Jhaveri, Mrinal M. Gounder, Danny N. Khalil, Alexander Drilon, Stefan Hamaway, Mary Kate Kasler, Dazhi Liu, Sandy Badson, Natalie M. Blauvelt, Maya Gambarin-Gelwan, Sebastian Mondaca, Bob T. Li, Marinela Capanu, Margaret K. Callahan, James J. Harding
Publikováno v:
Cancer
Background Data on drug-induced liver injury (DILI) and acute liver failure (ALF) in modern phase 1 oncology trials are limited, specifically with respect to the incidence and resolution of DILI and the safety of drug rechallenge. Methods This study
Autor:
Andrea Cercek, Christina Tran, J. Joshua Smith, Jinru Shia, Erin E. Salo-Mullen, Asha Krishnan, Kaitlyn Tkachuk, Garrett M. Nash, Philip B. Paty, Francisco Sanchez-Vega, Martin R. Weiser, S.Y. Ng, Chao Wu, Charles-Etienne Gabriel Sauve, Bryan C. Szeglin, Karyn A. Goodman, Julio Garcia-Aguilar, Arnold J. Markowitz, Neil H. Segal, Zalak Patel, Karuna Ganesh, Luis A. Diaz, Leonard B. Saltz, Zsofia K. Stadler, Rona Yaeger, Diane Reidy-Lagunes, Anna M. Varghese, Nikolaus Schultz, Gustavo Dos Santos Fernandes, Campbell S.D. Roxburgh, Jose G. Guillem
Publikováno v:
Clin Cancer Res
Purpose: Evaluate response of mismatch repair–deficient (dMMR) rectal cancer to neoadjuvant chemotherapy. Experimental Design: dMMR rectal tumors at Memorial Sloan Kettering Cancer Center (New York, NY) were retrospectively reviewed for characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781ea6f655b6556b2533218fac1c3e3c
https://europepmc.org/articles/PMC7348681/
https://europepmc.org/articles/PMC7348681/
Autor:
Joanne Chou, Marinela Capanu, Virginia Kelly, Anuradha Gopalan, Diane Reidy-Lagunes, Nitya Raj, Leonard B. Saltz, Charlotte E. Ariyan, Brian R. Untch, Youyun Zheng, Seth S. Katz, Michael F. Berger, Kelly Olino, Richard K. G. Do, Eileen M. O'Reilly, Neil H. Segal, Dmitriy Zamarin
Publikováno v:
J Clin Oncol
PURPOSE Adrenocortical carcinomas (ACC) are rare and aggressive malignancies with limited treatment options. This study was undertaken to evaluate the immunogenicity of ACC. PATIENTS AND METHODS Patients with advanced ACC were enrolled in a phase II