Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Louis C. Tan"'
Autor:
Wing Lok Au, Louis C. Tan, Kumar M. Prakash, Y.-Y. Ng, Jianjun Liu, H.-K. Kwok, Yi Zhao, Tatsushi Toda, Eng-King Tan, R. Pavanni, Wataru Satake, W.-T. Zhao
Publikováno v:
Neurology. 75:508-512
Objective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-li
Publikováno v:
Quality of Life Research. 19:565-569
The purpose of this study was to evaluate the responsiveness of the EQ-5D and the Parkinson’s Disease Questionnaire (PDQ-8) to deterioration in health-related quality of life (HRQoL) in patients with Parkinson’s disease (PD). HRQoL and clinical d
Publikováno v:
Neurology. 71:1727-1732
Objectives: To assess the association of ATP13A2 gene mutation among patients with early onset Parkinson disease (EOPD, onset Methods: Among 771 subjects, we studied 182 patients with EOPD and familial PD and 589 matched controls from two cohorts of
The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence
Autor:
L. Sun, R. Pavanni, Eng-King Tan, Chin Song Lu, Jianjun Liu, Prasanna R. Kolatkar, Lisa Skipper, Yih Yuen, E. Chua, Vincenzo Bonifati, Yi Zhao, Meng-Cheong Wong, M. G. Tan, S. Tang, Louis C. Tan, Stephanie Fook-Chong, A. Di Fonzo
Publikováno v:
Human Genetics, 120(6), 857-863. Springer-Verlag
Evidence of LRRK2 haplotypes associated with Parkinson's disease (PD) risk was recently found in the Chinese population from Singapore, and a common LRRK2 missense variant, Gly2385Arg, was independently detected as a putative risk factor for PD in th
Autor:
Jia Nee, Foo, Sun Ju, Chung, Louis C, Tan, Herty, Liany, Ho-Sung, Ryu, Myunghee, Hong, Tat Hung, Koh, Ishak D, Irwan, Wing-Lok, Au, Kumar-M, Prakash, Tin, Aung, Ching-Yu, Cheng, Siow-Ann, Chong, Chiea Chuen, Khor, Jimmy, Lee, E-Shyong, Tai, Eranga N, Vithana, Tien-Yin, Wong, Kyuyoung, Song, Jianjun, Liu, Eng-King, Tan
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 31(4)
Genome-wide association studies have identified several loci associated with Parkinson's disease (PD). Whole-exome sequencing detects rare coding variants, but their links with PD genome-wide association study loci are unknown. Our objective was to i
Autor:
Herty Liany, Jianjun Liu, Wing Lok Au, Jia Nee Foo, Kumar M. Prakash, Louis C. Tan, Eng-King Tan
Publikováno v:
Neurobiology of aging. 35(4)
Mutations in DNAJC13, DNAJC6 and DNAJC5 have been implicated in Parkinson's disease (PD). To determine if rare coding variants in these genes play a role in PD risk in the Chinese population, we sequenced all coding exons of the three genes in 99 ear
Autor:
Jia Nee Foo, Jianjun Liu, Yi-Chun Chen, Eng-King Tan, Louis C. Tan, Chiung Mei Chen, Kumar M. Prakash, Chia Wen Chang, Yih Ru Wu, Wing Lok Au, Jin Xin Bei, Yi Zhao, Tien Yin Wong
Publikováno v:
Neurology. 81(6)
Objective: A nonsense mutation in the amyotrophic lateral sclerosis gene FUS has been found to segregate in a large family with essential tremor (ET). Coding variants in this gene have not been comprehensively evaluated in ET. We conducted a genetic
Autor:
Yi Zhao, Yi-Chun Chen, Chiung Mei Chen, Yih Ru Wu, Kumar M. Prakash, Wing Lok Au, Guey Jen Lee-Chen, Zhong Pei, Eng-King Tan, Jin Sheng Zeng, Ling Chen, Yifan Zheng, X. Fu, Louis C. Tan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e36123 (2012)
PLoS ONE, Vol 7, Iss 7, p e36123 (2012)
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequenc
Autor:
R. Pavanni, Meng-Ling Chen, R. Li, Yih Yuen, Hui-Qin Lim, Kumar M. Prakash, Ruey-Meei Wu, Chin-Hslen Lin, Yi Zhao, Louis C. Tan, Chun-Hwei Tai, Eng-King Tan
Publikováno v:
Human genetics. 126(3)
Mutations in the GIGYF2 gene at the PARK11 locus have recently been reported in Parkinson’s disease (PD). However, the pathogenicity of some of these mutations has been debated. We conducted a comprehensive genetic analysis of the entire GIGYF2 gen
Autor:
Hon Chung Fung, J.M. Burgunder, Chiung Mei Chen, Louis C. Tan, Rong Peng, Yi-Hsin Weng, Yik Ying Teo, Chin Song Lu, Rou-Shayn Chen, Yih-Ru Wu, Z.J. Zhang, M.C. Lee, Stephanie Fook-Chong, Eng-King Tan, Guey Jen Lee-Chen, X.K. An, Ruey-Meei Wu, Yah Huei Wu-Chou
Publikováno v:
Neurobiology of aging. 31(12)
The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson’s disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset e