Zobrazeno 1 - 10
of 31
pro vyhledávání: '"David Lyden"'
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz
Publikováno v:
Developmental Cell. 49:347-360
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and t
Autor:
Irina Matei, Jonathan M. Hernandez, DooA Kim, Ayuko Hoshino, David Lyden, William R. Jarnagin, Virginia Pascual, Todd E. Heaton, Serena Lucotti, Gabriel C. Tobias, Kyung A. Kim, Haiying Zhang, Han Sang Kim, Linda Bojmar, Kofi Ennu Gyan, Fanny A. Pelissier Vatter, Zurong Wan, David R. Jones, David P. Kelsen, Tanya M. Trippett, Candia M. Kenific, Michael P. La Quaglia
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 1, Pp 100225-(2021)
STAR Protocols, Vol 2, Iss 1, Pp 100225-(2021)
Summary We developed a modified protocol, based on differential ultracentrifugation (dUC), to isolate extracellular vesicles and particles (specifically exomeres) (EVPs) from various human and murine sources, including cell lines, surgically resected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b22bbd78d2b60c5fa3931c47b9f4e5
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184039
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184039
Autor:
Kiichi Nakahira, Irina Matei, Brinda K. Rana, Ebrahim Afshinnekoo, Susan M. Bailey, Stephan Ossowski, Christopher E. Mason, Varsha Rao, Philip Burnham, Michael Snyder, Tejaswini Mishra, David P. Kelsen, Francine E. Garrett-Bakelman, Lynn Taylor, Serena Lucotti, Jonathan Foox, David Lyden, Kenneth H. Yu, Iwijn De Vlaminck, Daniel Butler, Haiying Zhang, Cem Meydan, Ari Melnick, Daniela Bezdan, Craig Westover, Michele Cioffi, Matthew MacKay, Fanny A. Pelissier Vatter, Kirill Grigorev, Chris Moszary
The health impact of prolonged space flight on the human body is not well understood. Liquid biopsies based on cell-free DNA (cfDNA) or exosome analysis provide a noninvasive approach to monitor the dynamics of genomic, epigenomic and proteomic bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a2fc2a7a9c61bf9c947e761a16d0f6c
https://doi.org/10.1101/2020.11.08.373530
https://doi.org/10.1101/2020.11.08.373530
Autor:
Christopher E. Mason, Serena Lucotti, Ebrahim Afshinnekoo, Daniela Bezdan, David P. Kelsen, David Lyden, Kiichi Nakahira, Tejaswini Mishra, Michele Cioffi, Susan M. Bailey, Irina Matei, Matthew MacKay, Varsha Rao, Lynn Taylor, Fanny A. Pelissier Vatter, Craig Westover, Philip Burnham, Haiying Zhang, Kenneth H. Yu, Ari Melnick, Cem Meydan, Kirill Grigorev, Stephan Ossowski, Jonathan Foox, Chris Mozsary, Michael Snyder, Daniel Butler, Timothy Donahoe, Francine E. Garrett-Bakelman, Iwijn De Vlaminck, Brinda K. Rana
Publikováno v:
iScience
iScience, Vol 23, Iss 12, Pp 101844-(2020)
iScience, Vol 23, Iss 12, Pp 101844-(2020)
Summary Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach to monitor human health and disease but have not been utilized for astronauts. Here, we profile cfDNA characteristics, including fragment size, cellular
Publikováno v:
Nature Cell Biology. 21:795-797
Tumour-secreted microvesicles carry bioactive molecules that can be transferred to recipient cells, impacting tumour progression. A study now shows that ARF6 drives miRNA loading into tumour microvesicles through interaction with pre-miRNA–Exportin
Autor:
E. Popa, David Lyden, Sorin Alexandrescu, N.I. Luca, Doru Paul, V.M. Croitoru, I. Sandra, Irina M. Cazacu, I-M. Gramaticu, Andrei Sorop, Irina Matei, Mircea Diculescu, Adina Croitoru, Simona Dima, C. Gheorghe, D. Bogdan, I.M. Dinu, Vlad Herlea, Irinel Popescu
Publikováno v:
Annals of Oncology. 32:S1371
Autor:
Kofi Ennu Gyan, Han Sang Kim, Haiying Zhang, Irina Matei, Ayuko Hoshino, Linda Bojmar, David Lyden
Publikováno v:
Cancer Research. 81:IA024-IA024
In 1889, Stephen Paget first proposed that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. A growing number of studies demonstrate that tumor-derived microv
Autor:
Alberto Benito-Martin, Antonio Strillacci, David Lyden, Claudia Savini, Pasquale Sansone, Sabrina De Carolis, John H. Healey, Enzo Spisni, Robert L. Bowman, Qing Chang, Vinagolu K. Rajasekhar, Chiara Mastroleo, Marjan Berishaj, Fabiana Perna, Massimiliano Bonafè, Laura Daly, Nicola Fabbri, Monica Cricca, Claudio Ceccarelli, Jacqueline Bromberg, Lauren Q. Shapiro
Publikováno v:
Cancer Research. 77:1927-1941
The hypothesis that microvesicle-mediated miRNA transfer converts noncancer stem cells into cancer stem cells (CSC) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstratin
Publikováno v:
Cell. 170:223-225
Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses. Although endogenous RNAs acting as damage-associated molecular patterns (DAMPs) for pattern recognition