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Autor:
Octavio Monasterio, Rosalba Lagos, Julio Benites, Julien Verrax, Pedro Buc Calderon, Daniel Maturana, Cristian Escobar, Jaime A. Valderrama, Eunices Gutierrez, Esteban Nova, Felipe Villanelo
Publikováno v:
Biochemical and biophysical research communications. 466(3)
Dihydroxynaphthyl aryl ketones 1-5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and docking analysis showed that