Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Ingemar Björkhem"'
Autor:
Curt Einarsson, Ingemar Björkhem, Stefan E.H. Alexson, Margareta A. Diczfalusy, Ulla Andersson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1439:40-46
Long chain acyl-CoA thioesterase activity is mainly located in microsomes after subcellular fractionation of liver from untreated rats. The physiological function and regulation of expression of this activity is not known. In the present study we hav
Publikováno v:
Europe PubMed Central
Journal of Lipid Research, Vol 35, Iss 2, Pp 319-327 (1994)
Journal of Lipid Research, Vol 35, Iss 2, Pp 319-327 (1994)
Among nine strains of rat, two were found that responded to phenobarbital treatment with increased activity of hepatic cholesterol 7 alpha-hydroxylase. This effect was maximal after 2-3 days of treatment and was then reduced. Interestingly the increa
Publikováno v:
Europe PubMed Central
Journal of Lipid Research, Vol 34, Iss 9, Pp 1497-1503 (1993)
Journal of Lipid Research, Vol 34, Iss 9, Pp 1497-1503 (1993)
The mechanism of down-regulation of hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase by cholic acid (CA) and chenodeoxycholic acid (CDCA) was investigated in rats with a lymph fistula. In accordance with the contention that bile acids ar
Publikováno v:
European Journal of Biochemistry. 215:705-710
Rats of the Sprague-Dawley strain were infused intravenously with a fat emulsion (Intralipid, trademark of Kabi Pharmacia, Uppsala, Sweden) containing 7-oxocholesterol. This resulted in an increased cholesterol 7 alpha-hydroxylase activity in liver m
Publikováno v:
Europe PubMed Central
Journal of Lipid Research, Vol 33, Iss 11, Pp 1591-1595 (1992)
Journal of Lipid Research, Vol 33, Iss 11, Pp 1591-1595 (1992)
Interruption of the enterohepatic circulation by cholestyramine causes a several-fold increase in bile acid synthesis, reflected in a stimulation of cholesterol 7 alpha-hydroxylase activity; the synthesis of cholic acid being stimulated to a greater
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
The mechanism and stereochemistry in connection with enzymatic conversion of cholesta-4,6-dien-3-one into cholestanol was studied. Rat and mouse liver microsomes are able to catalyze NADPH-dependent sequential saturation of the two double bonds. Evid
Publikováno v:
Europe PubMed Central
Human liver microsomes were found to catalyze 7 alpha-hydroxylation of 27-hydroxycholesterol at a rate of up to about 0.2 nmol/mg protein per min. The product of the reaction, 5-cholestene-3 beta, 7 alpha, 27-triol, was identified by means of combine
Autor:
Kjell Wikvall, Ingemar Björkhem, Ulla Andersson, Irina A. Pikuleva, Maria Norlin, H. Pettersson, Alexander Yu. Misharin
Publikováno v:
Biochimica et biophysica acta. 1781(8)
The synthetic inhibitors of sterol biosynthesis, 3beta-hydroxy-5alpha-cholest-8(14)-en-15-one and 3beta-hydroxy-24S-methyl-5alpha-cholesta-8(14),22-dien-15-one, are of interest as potential cholesterol lowering drugs. Rapid metabolism of synthetic 15
Autor:
S. Ewerth, Ingemar Björkhem, D. Ståhlberg, Lars Berglund, Bo Angelin, Eva Reihnér, Kurt Einarsson, Mats Rudling
Publikováno v:
Scopus-Elsevier
Inhibitors of the rate-limiting enzyme of cholesterol biosynthesis, 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, are now used frequently to treat hypercholesterolemia. We studied the effects of specific inhibition of cholesterol synthe
Publikováno v:
Journal of Lipid Research, Vol 31, Iss 6, Pp 1083-1088 (1990)
Scopus-Elsevier
Europe PubMed Central
Scopus-Elsevier
Europe PubMed Central
The metabolic fate of intravenously administered [4-14C]sitosterol was studied in two healthy subjects. In marked contrast to the results of a previous investigation with [22,23-3H]sitosterol, no detectable labeled C24-bile acid products appeared in