Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Franz J. Zemp"'
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 722:114-118
Ionizing radiation is an important treatment modality, but it is also a well-known genotoxic agent capable of damaging cells and tissues. Therefore radiation treatment can cause numerous side effects in exposed tissues and organs. Radiotherapy is a p
Publikováno v:
Biochemical and Biophysical Research Communications. 377:41-45
To investigate involvement of miRNAs in radiation responses we used microRNAome profiling to analyze the sex-specific response of radiation sensitive hematopoietic lymphoid tissues. We show that radiation exposure resulted in a significant and sex-sp
Autor:
Olga Kovalchuk, Bryan Kolb, Igor Koturbash, Franz J. Zemp, Kristy Kutanzi, Jonathan M. Loree, Lidiya Luzhna
Publikováno v:
Cell Cycle. 7:1658-1667
The bystander effect is a phenomenon that occurs when exposed cells signal distress to their naïve, unexposed neighbors. It is now accepted as a ubiquitous consequence of radiation exposure. It is well documented to occur in cultured cells, 3D tissu
Autor:
Igor Kovalchuk, Olga Kovalchuk, Frederick A. Beland, Igor P. Pogribny, Beverly Montgomery, Alex Boyko, Volodymyr Tryndyak, John R. Latendresse, Alan Warbritton, Kristy Kutanzi, Franz J. Zemp
Publikováno v:
Cell Cycle. 6:2010-2018
Breast cancer is the most common malignancy in women continuing to rise worldwide. Breast cancer emerges through a multi-step process, encompassing progressive changes from a normal cell to hyperplasia (with and without atypia), carcinoma in situ, in
Autor:
Franz J. Zemp, Alvin M. Altamirano, Olga A. Sedelnikova, Olga Kovalchuk, William M. Bonner, Jennifer S. Dickey
Publikováno v:
Radiation protection dosimetry. 143(2-4)
Upon DNA double-strand break (DSB) formation, hundreds of H2AX molecules in the chromatin flanking the break site are phosphorylated on serine residue 139, termed gamma-H2AX, so that virtually every DSB site in a nucleus can be visualised within 10 m
Autor:
Gloria Jenkins-Baker, Stephen A. Marino, David J. Brenner, Franz J. Zemp, Jody Filkowski, William M. Bonner, Alvin M. Altamirano, Olga Kovalchuk, Jennifer S. Dickey, Olga A. Sedelnikova
Publikováno v:
Carcinogenesis. 31(10)
The radiation-induced bystander effect (RIBE) is a phenomenon whereby unexposed cells exhibit molecular symptoms of stress exposure when adjacent or nearby cells are traversed by ionizing radiation (IR). Recent data suggest that RIBE may be epigeneti
Publikováno v:
Mutation research. 722(2)
Small non-coding RNAs-microRNAs, are potent negative regulators of gene expression. MicroRNAs are involved in multiple biological processes, metabolic regulation, including cell proliferation, differentiation, and programmed cell death. Since the dys