Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Dipanjan Chowdhury"'
Autor:
Allison Gockley, Konrad Pagacz, Stephen Fiascone, Konrad Stawiski, Nicole Holub, Kathleen Hasselblatt, Daniel W. Cramer, Wojciech Fendler, Dipanjan Chowdhury, Kevin M. Elias
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Neural network analyses of circulating miRNAs have shown potential as non-invasive screening tests for ovarian cancer. A clinically useful test would detect occult disease when complete cytoreduction is most feasible. Here we used murine xenografts t
Externí odkaz:
https://doaj.org/article/9d8861da54ff467785e0f139b9f5edb2
Autor:
Teresa Cheng, Brooke E. Howitt, Dipanjan Chowdhury, Martin T. King, Ursula A. Matulonis, Panagiotis A. Konstantinopoulos, Wojciech Fendler, Konrad Stawiski, Larissa J. Lee
Publikováno v:
Gynecol Oncol
Objective Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer associated with worse survival outcomes in African American (AA) patients. This study evaluated tumor miRNA expression by race, clinical and tumor characteristics
Autor:
Wojciech Fendler, Bartłomiej Tomasik, Chandan Guha, Beata Małachowska, Shilpa Kulkarni, Dipanjan Chowdhury, Konrad Stawiski
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 106:390-402
Purpose MicroRNAs (miRNAs) were hypothesized to be robust and easily measured biomarkers of radiation exposure, which has led to multiple studies in various clinical and experimental scenarios. We sought to identify evolutionary conserved, radiation-
Autor:
Daphne A. Haas-Kogan, Zuzanna Nowicka, Konrad Stawiski, David Kozono, Dipanjan Chowdhury, Thomas Johnson, Wojciech Fendler, B. Tomasik, Marek Ussowicz
Mouse and non-human primate models showed that serum miRNAs may be used to predict the biological impact of radiation doses. We hypothesized that these results can be translated to humans treated with total body irradiation (TBI), and that miRNAs may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa1ec0334d6fe0d61f4b0140ef46f05
https://doi.org/10.1101/2021.08.23.21262229
https://doi.org/10.1101/2021.08.23.21262229
Publikováno v:
Translational Research. 201:71-83
Due to tremendous technological advances, radiation oncologists are now capable of personalized treatment plans and deliver the dose in a highly precise manner. However, a crucial challenge is how to escalate radiation doses to cancer cells while red
Autor:
Urszula Smyczynska, Dipanjan Chowdhury, Szymon Grabia, Wojciech Fendler, Konrad Pagacz, Przemysław Kucharski
Publikováno v:
BMC Genomics
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
BackgroundThe consensus on how to choose a reference gene for serum or plasma miRNA expression qPCR studies has not been reached and none of the potential candidates have yet been convincingly validated. We proposed a new in silico approach of findin
Autor:
Panagiotis A. Konstantinopoulos, Karin K. Shih, Young Eun Choi, Marie Eve Brault, Ronny Drapkin, David M. Weinstock, Tovah A. Day, Dipanjan Chowdhury, Khyati Meghani, Fanny Dao, Douglas A. Levine, Lucas Leclerc, Kevin M. Elias, Yizhou Joseph He, Ursula A. Matulonis
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 429-439 (2016)
SummaryHigh-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum and poly(ADP-ribose) polymerase inhibitors [PARPis]) due to an under
Autor:
Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury, Alexandre Detappe, Ewa Gogola, Jos Jonkers, Khyati Meghani, Ursula A. Matulonis, Pascal Drané, Sven Rottenberg, Walker Fuchs, Elizabeth M. Swisher
Publikováno v:
Meghani, Khyati; Fuchs, Walker; Detappe, Alexandre; Drané, Pascal; Gogola, Ewa; Rottenberg, Sven; Jonkers, Jos; Matulonis, Ursula; Swisher, Elizabeth M; Konstantinopoulos, Panagiotis A; Chowdhury, Dipanjan (2018). Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas. Cell reports, 23(1), pp. 100-111. Cell Press 10.1016/j.celrep.2018.03.038
Cell Reports, Vol 23, Iss 1, Pp 100-111 (2018)
Cell Reports, Vol 23, Iss 1, Pp 100-111 (2018)
Summary: BRCA1/2-mutated ovarian cancers (OCs) are defective in homologous recombination repair (HRR) of double-strand breaks (DSBs) and thereby sensitive to platinum and PARP inhibitors (PARPis). Multiple PARPis have recently received US Food and Dr
Autor:
Konrad Stawiski, Panagiotis A. Konstantinopoulos, Magdalena Kędzierska, Allison F. Vitonis, Daniel W. Cramer, Wojciech Fendler, Stephen Fiascone, Dipanjan Chowdhury, Christopher P. Crum, Kevin M. Elias, Ross S. Berkowitz, Gyorgy Frendl
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Recent studies posit a role for non-coding RNAs in epithelial ovarian cancer (EOC). Combining small RNA sequencing from 179 human serum samples with a neural network analysis produced a miRNA algorithm for diagnosis of EOC (AUC 0.90; 95% CI: 0.81–0
Autor:
Young Eun Choi, Patryk Moskwa, Pascal O. Zinn, Sachet A. Shukla, Todd R. Golub, Clark C. Chen, Dipanjan Chowdhury, Wojciech Fendler, Anita B. Hjelmeland, Jun Lu
Publikováno v:
Molecular Cancer Research. 12:1767-1778
The efficacy of radiotherapy in many tumor types is limited by normal tissue toxicity and by intrinsic or acquired radioresistance. Therefore, it is essential to understand the molecular network responsible for regulating radiosensitivity/resistance.