Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Richard A, Koup"'
Autor:
Jeffrey D. Lifson, John R. Mascola, Sean P. O’Brien, Theodora Hatziioannou, Paul D. Bieniasz, Jason Gorman, Brandon F. Keele, George M. Shaw, Gregory Q. Del Prete, Richard A. Koup, Taina T. Immonen, Adrienne E. Swanstrom, Christine M. Fennessey, Amarendra Pegu, Kathryn E. Foulds, Nicole A. Doria-Rose, Peter D. Kwong, Sung-Youl Ko, Mario Roederer, Carolyn Williamson, Stephen D. Schmidt, Hui Li
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore,
Autor:
Jumpol Sopanaporn, Weerawan Chuenarom, Boot Keawboon, Dan H. Barouch, Wei Shi, John R. Mascola, Richard A. Koup, Merlin L. Robb, Sandhya Vasan, Rawiwan Imerbsin, Amarendra Pegu, Nelson L. Michael, Dutsadee Inthawong, Alexandra Schuetz, Pornsuk Visudhiphan, Decha Silsorn, Romas Geleziunas, Denise C. Hsu
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009339 (2021)
PLoS Pathogens
PLoS Pathogens
Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after an
Autor:
Martin R Gaudinski, Emily E Coates, Katherine V Houser, Grace L Chen, Galina Yamshchikov, Jamie G Saunders, LaSonji A Holman, Ingelise Gordon, Sarah Plummer, Cynthia S Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T Bailer, Sandeep Narpala, Adrian B McDermott, Aryan M Namboodiri, Janardan P Pandey, Richard M Schwartz, Zonghui Hu, Richard A Koup, Edmund Capparelli, Barney S Graham, John R Mascola, Julie E Ledgerwood, VRC 606 Study Team
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002493 (2018)
PLoS Medicine
PLoS Medicine
Background VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of the HIV-1 envelope glycoprotein (Env) that is currently being evaluated in a Phase IIb adult HIV-1 prevention efficacy trial. VRC01LS is a mo
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev, John T. Patton
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activatio
Autor:
Richard A. Koup, Patrick Younan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Michael G. Katze, Rodrigo I. Santos, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006397 (2017)
PLoS Pathogens
PLoS Pathogens
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a ‘sepsis-like’ syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however
Autor:
John R. Mascola, Barney S. Graham, Peter B. Gilbert, Hong Zhao, Steven Lepore, M. Juliana McElrath, Michal Juraska, Jerome H. Kim, Morgane Rolland, Allan C. deCamp, Hongjun Bai, James I. Mullins, Robert T. Bailer, Robert J. O'Connell, Breana Hall, Sodsai Tovanabutra, Richard A. Koup, Shelly Karuna, Annemarie O'Sullivan, Elizabeth Adams, Shana Miller, Daniel E. Geraghty, Eric Sanders-Buell, Hasan Ahmed, Craig A. Magaret, Lindsay N. Carpp, Kalpana Dommaraju, Mario Roederer, Scott M. Hammer, Lawrence Corey, Kultida Poltavee, Raphael Gottardo, Matthew Zirui Tay, Andrew Fiore-Gartland, Nelson L. Michael, Derrick Goodman, Kim G. Wong, Patricia D'Souza, Magdalena E. Sobieszczyk, Lisa M. Frenkel, Paul T. Edlefsen, Meera Bose, Sheila Styrchak, Georgia D. Tomaras, Lennie Chen, Merlin L. Robb, Nicole Frahm, James G. Kublin
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0185959 (2017)
PLoS ONE
PLoS ONE
Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that
Autor:
Marlous L. Grijsen, John R. Mascola, Rebecca M. Lynch, Adam K. Wheatley, Jan M. Prins, Richard A. Koup, Madhu Prabhakaran, Godelieve J. de Bree, Adrian B. McDermott, Stephen D. Schmidt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
Background Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunitie
Autor:
Timothy J. Wilkin, Philip L. Felgner, Johannes S. Gach, Chase T. M. Anderson, Steven G. Deeks, Christine Katlama, Donald N. Forthal, Andrea Gorlani, Chad J. Achenbach, Brigitte Autran, Richard A. Koup, Emmanuel Y. Dotsey, Joseph P. Casazza, Baiba Berzins, Juan C. Becerra, Robert L. Murphy
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160341 (2016)
PLoS ONE
PloS one, vol 11, iss 8
PLoS ONE
PloS one, vol 11, iss 8
Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular immune respo
Autor:
Takuya Yamamoto, Richard A. Koup, Michael R. Betts, Ole Lund, Marcus Buggert, Johanna Tauriainen, Juliet Wairimu Frederiksen, Marianne Jansson, Martin A. Ivarsson, Jakob Michaëlsson, Anders Sönnerborg, Bo Hejdeman, Annika C. Karlsson
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004251 (2014)
PLoS Pathogens; 10(7), no e1004251 (2014)
PLoS Pathogens
Buggert, M, Tauriainen, J, Yamamoto, T, Frederiksen, J W, Ivarsson, M A, Michaelsson, J, Lund, O, Hejdeman, B, Jansson, M, Sonnerborg, A, Koup, R A, Betts, M R & Karlsson, A C 2014, ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ', P L o S Pathogens, vol. 10, no. 7, e1004251 . https://doi.org/10.1371/journal.ppat.1004251
PLoS Pathogens; 10(7), no e1004251 (2014)
PLoS Pathogens
Buggert, M, Tauriainen, J, Yamamoto, T, Frederiksen, J W, Ivarsson, M A, Michaelsson, J, Lund, O, Hejdeman, B, Jansson, M, Sonnerborg, A, Koup, R A, Betts, M R & Karlsson, A C 2014, ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ', P L o S Pathogens, vol. 10, no. 7, e1004251 . https://doi.org/10.1371/journal.ppat.1004251
CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exh
Autor:
Ndongala Michel Lubaki, Patrick Younan, Rodrigo I Santos, Michelle Meyer, Mathieu Iampietro, Richard A Koup, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006031 (2016)
PLoS Pathogens
PLoS Pathogens
Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblock