Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Weihong Song"'
Autor:
Fang Cai, Wenyuan Tao, Shu Shu, Zi Zhuang, Yun Xu, Xiaolei Zhu, Xinyu Bao, Siyi Xu, Weihong Song, Linjie Yu, Yue Gu, Ying Liu
Publikováno v:
Mol Ther
Alzheimer’s disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly, and the mechanisms of AD are not fully defined. MicroRNAs (miRNAs) have been shown to contribute to memory deficits in AD. In this study, we
Autor:
Hao-Lun Sun, Jun-Ping Wang, Si-Han Chen, Jun Wang, Yuan Cheng, Pu-Yang Sun, Weihong Song, Zhian Hu, Dong-Yu Fan, Chen-Yang He, Xiaowei Chen, Ding-Yuan Tian, Xian-Le Bu, Yan-Jiang Wang, Hua-Dong Zhou, Zhong-Yuan Yu, Cheng-Rong Tan, Yang Chen
Publikováno v:
Molecular Psychiatry. 26:5568-5577
It is traditionally believed that cerebral amyloid-beta (Aβ) deposits are derived from the brain itself in Alzheimer's disease (AD). Peripheral cells such as blood cells also produce Aβ. The role of peripherally produced Aβ in the pathogenesis of
Autor:
Wei-Wei Li, Jin-Tai Yu, Li-Yong Chen, Wei Xu, Wang-Sheng Jin, Chi Zhu, Yang Xiang, Xiaowei Chen, Zhiming Zhu, Zhian Hu, Xian-Le Bu, Hua-Dong Zhou, Jun Wang, Zhen Wang, Ding-Yuan Tian, Gui-Hua Zeng, Bin-Lu Sun, Yan-Jiang Wang, Yu-Hui Liu, Lin-Lin Shen, Weihong Song
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry
Translational Psychiatry
Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the AD intervention from treatment to preven
Publikováno v:
Molecular Neurobiology. 57:3150-3157
Alzheimer's disease (AD) is the most common neurodegenerative disease, and there has been no disease-modifying treatment for AD. Recent studies suggest that trehalose may have beneficial effect on neurodegenerative diseases through regulating autopha
Autor:
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, LuLin Jiang, Tiantian Guo, Mingyu Shen, Huan Hou, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Fanwei Zeng, Xiu-Fang Zhang, Hong Luo, Xian Zhang, Hongfeng Zhang, Zhiping Zeng, Timothy Y. Huang, Chen Dong, Hong Qing, Yun Zhang, Qing Zhang, Xu Wang, Yili Wu, Huaxi Xu, Weihong Song, Xin Wang
Publikováno v:
The Journal of clinical investigation. 132(5)
Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer's disease (AD), implicating key roles for chromosome 21-encoded genes in the pathogenesis of AD. We previously identified a role for the deubiquitinase U
Autor:
Yufei Mei, Jihui Lyv, Wenhong Luo, Rongqiao He, Xu Yang, Xiangpei Yue, Weihong Song, Li Ai, Yan Yu, Yun Zhang, Hongjun Luo, Wenjing Jiang, Zhiqian Tong, Xuechao Fei, Hui Li
Publikováno v:
Molecular psychiatry. 26(10)
Dysregulation of formaldehyde (FA) has been implicated in the development of Alzheimer's Disease (AD). Elevated FA levels in Alzheimer's patients and animal models are associated with impaired cognitive functions. However, the exact role of FA in AD
Autor:
Lu Shen, Tahereh Bozorgmehr, Daochao Huang, Jifeng Guo, Yili Wu, Catharine H. Rankin, Si Zhang, Beisha Tang, Zhe Wang, Fang Cai, Weihong Song, Shuting Zhang
Publikováno v:
Molecular Psychiatry. 25:603-613
Presenilin-1 (PSEN1) is the catalytic subunit of the γ-secretase complex, and pathogenic mutations in the PSEN1 gene account for the majority cases of familial AD (FAD). FAD-associated mutant PSEN1 proteins have been shown to affect APP processing a
Autor:
Hua-Dong Zhou, Yu-Hui Liu, Weihong Song, Jun Wang, Zhi-Qiang Xu, Fan Zeng, Jin-Tai Yu, Peng Lei, Yan-Jiang Wang, Noralyn B. Mañucat-Tan, Xiu-Qing Yao, Xian-Le Bu, Wei-Wei Li, Xin-Fu Zhou, Chi Zhu, Changyue Yue Gao, Larisa Bobrovskaya, Shi-Hao Gao, Lin-Lin Shen
Publikováno v:
Molecular Psychiatry. 23:1813-1824
Tau pathology is characterized as a form of frontotemporal lobar degeneration (FTLD) known as FTLD-tau. The underlying pathogenic mechanisms are not known and no therapeutic interventions are currently available. Here, we report that the neurotrophin
Autor:
Zhilin Huang, Zhian Hu, Wang-Sheng Jin, Jia-Xiang Xiong, Weihong Song, Wei-Wei Zhang, Yan-Jiang Wang, Xin-Fu Zhou, Ya-Ni He, Zhifang Dong, Chang-Yue Gao, Lin-Lin Shen, Si-Han Chen, Yi-Zheng Wang, Xian-Le Bu, Hua-Dong Zhou
Publikováno v:
Acta Neuropathologica. 134:207-220
Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. In a previous
Autor:
Weihong Song, Yu Tian Wang, Junjie Li, Yayan Pang, Yehong Du, Min Fu, Zhilin Huang, Xin Tian, Zhifang Dong
Publikováno v:
Aging Cell
Alzheimer's disease (AD) is one of the most common causes of neurodegenerative diseases in the elderly. The accumulation of amyloid‐β (Aβ) peptides is one of the pathological hallmarks of AD and leads to the impairments of synaptic plasticity and