Zobrazeno 11 - 20
of 27
pro vyhledávání: '"Weihong Song"'
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Background Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine. Chronic inflammation induced by amyloid β proteins (Aβ) is one prominent neuropathological feature in Alzheimer’s disease (AD) brain. Methods Elisa, Western b
Mutations in amyloid β precursor protein (APP) gene alter APP processing, either causing familial Alzheimer's disease (AD) or protecting against dementia. Under normal conditions, β-site APP cleaving enzyme 1 (BACE1) cleaves APP at minor Asp(1) sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6ae3a9761976ff5cb018db5c101696
https://europepmc.org/articles/PMC6705717/
https://europepmc.org/articles/PMC6705717/
Autor:
Zhe Wang, Weihong Song, Weitao Zhou, Dandan Lou, Mengjiao Yu, Lingling Zheng, Daochao Huang, Fang Cai, Weihui Zhou, Shou Yang, Tingyu Li
Publikováno v:
Molecular neurobiology. 55(6)
The majority of Alzheimer’s disease (AD) cases are sporadic with unknown causes. Many dietary factors including excessive alcohol intake have been reported to increase the risk to develop AD. The effect of alcohol on cognitive functions and AD path
Autor:
Zhen Fan, Zhe Wang, Qian Chen, Hongpeng Jiang, Yili Wu, Weihong Song, Jiaying Zeng, Jie Chen, Li Chen, Lan Ren, Tingyu Li
Publikováno v:
Acta neuropathologica. 133(6)
Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the unique pathological hallmark of Alzheimer’s disease (AD). Aβ is derived from amyloid β precursor protein (APP) by β- and γ-secretase cleavages and turned over b
Autor:
Ha-Na Woo, Simonetta Camandola, Mohamed R. Mughal, Jun-Hyung Park, Jong-Sung Park, Mark P. Mattson, Sung-Chun Tang, A-Ryeong Gwon, Huaibin Cai, Weihong Song, Thiruma V. Arumugam, William R. Markesbery, Dong-Gyu Jo, Aiwu Cheng, Dong-Hoon Hyun, Yun-Hyung Choi
Publikováno v:
Neurobiology of Aging. 31:917-925
Beta-secretase (BACE1), an enzyme responsible for the production of amyloid beta-peptide (Abeta), is increased by oxidative stress and is elevated in the brains of patients with sporadic Alzheimer's disease (AD). Here, we show that oxidative stress f
Autor:
Hua‑Dong Zhou, Jun Tan, Yan-Jiang Wang, Xiao‑Yan Zhu, Weihong Song, Xin-Fu Zhou, Xian-Le Bu, Yang Xiang, Brian Giunta, Lin-Lin Shen, Yu‑Hui Liu, Chi Zhu, Shu‑Sheng Jiao
Publikováno v:
Acta Neuropathologica
Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived Aβ and its therapeutic potential for AD remains largely unknown. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0215efabcfac2b24a780bf4499fc0376
https://hdl.handle.net/11541.2/116155
https://hdl.handle.net/11541.2/116155
Autor:
Frederick A. Dobie, Weihui Zhou, L. Eric Huang, Guiqiong He, Weihong Song, Fang Cai, Hong Qing, Xiulian Sun, Matthias Staufenbiel
Publikováno v:
Proceedings of the National Academy of Sciences. 103:18727-18732
The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic Alzheimer's disease (AD) is unknown. A history of stroke was found to be associated with development of some AD cases, especially in the presence of vascular ris
Publikováno v:
Scientific Reports
Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer's disease (AD). Aβ is produced by β- and γ-cleavages of amyloid β precursor protein (APP). Ubiquitin carboxyl-terminal hydrolas
Autor:
Todd Charlton Sacktor, Shu Zhang, Weihong Song, Yu Tian Wang, Man Tu, Mingjing Liu, Xiaobin Wu, Wei Wang, Huili Han, Xiaoyan Wu, Wuyang Jin, Yanrui Bai, Limin Zhou, Yan Peng, Zhifang Dong, Hongjie Li, Wenting He, Tingyu Li, Weihui Zhou, Tao Tan
Publikováno v:
The Journal of clinical investigation. 125(1)
Long-term potentiation (LTP) of synaptic strength between hippocampal neurons is associated with learning and memory, and LTP dysfunction is thought to underlie memory loss. LTP can be temporally and mechanistically classified into decaying (early-ph
Autor:
Zhuohua Zhang, Shuting Zhang, Yawen Luo, Weihui Zhou, Tingyu Li, Yu Deng, Weihong Song, Yili Wu, Fang Cai
Publikováno v:
Neurobiology of aging. 36(1)
Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major