Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hisashi Oishi"'
Autor:
Chihiro Kurematsu, Masato Sawada, Masaki Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, Mami Matsumoto, Hisashi Oishi, Hiroyuki Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, Truc Quynh Thai, Shinichi Kohsaka, Nobuhiko Ohno, Maki K. Yamada, Masato Asai, Masahiro Sokabe, Junichi Nabekura, Kenichi Asano, Masato Tanaka, Kazunobu Sawamoto
Publikováno v:
Journal of Experimental Medicine. 219
New neurons, continuously added in the adult olfactory bulb (OB) and hippocampus, are involved in information processing in neural circuits. Here, we show that synaptic pruning of adult-born neurons by microglia depends on phosphatidylserine (PS), wh
Autor:
Keigyou Yoh, Ryusuke Koshida, Masafumi Muratani, Hyojung Jeon, Takaaki Ojima, Yuki Imamura, Michito Hamada, Naoki Morito, Maho Kanai, Hideki Yokoi, Manoj Kumar Yadav, Satoru Takahashi, Ashio Yoshimura, Hisashi Oishi, Masato Kasahara, Toshiaki Usui, Keigo Asano, Hossam H. Shawki, Joichi Usui, Yoshinori Sato, Akihiro Kuno, Takashi Kudo, Yuki Tsunakawa, Kunihiro Yamagata, Risa Okada, Hiroyasu Tsukaguchi
Publikováno v:
Kidney International. 98:391-403
Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant nephrotic syndrome. Spontaneous remission of FSGS is rare and steroid-resistant FSGS frequently progresses to renal failure. Many inheritable forms of FSGS have been des
Autor:
Hitomi Tsuiji, Himari Ogino, Tomofumi Shigenobu, Takao Kohno, Eisuke Okugawa, Yuko Yamakage, Mitsuharu Hattori, Hisashi Oishi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Reelin is a secreted protein that plays versatile roles in neuronal development and function, and hypoactivity of Reelin is implicated in many neuropsychiatric disorders. The strength of Reelin signaling is regulated by proteolytic processing, but it
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(7)
Increased muscle contractile activity, as observed with regular exercise, prevents oxidative stress-induced muscle wasting, at least partially, by improving the antioxidant defense system. Phosphorylated p62/sequestosome1 competitively binds to the K
Autor:
Daisuke Ieda, Tomomi Miyamoto, Makoto Nakanishi, Yutaka Negishi, Kohji Kato, Shinya Ugawa, Hisashi Oishi, Natsuko Kumamoto, Shinji Saitoh, Ichiro Miyoshi, Yoshikazu Johmura
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237814 (2020)
PLoS ONE
PLoS ONE
Schaaf-Yang syndrome (SYS) is a neurodevelopmental disorder caused by truncating variants in the paternal allele of MAGEL2, located in the Prader-Willi critical region, 15q11-q13. Although the phenotypes of SYS overlap those of Prader-Willi syndrome
Autor:
Chia Jui Ku, Sakie Ohmura, Mary Hermann, Satoru Takahashi, Tomonori Hosoya, Hisashi Oishi, James Douglas Engel, Seiya Mizuno
Publikováno v:
The journal of clinical investigation. 126(3):865-878
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has pathological consequences. Previous studies have shown that GATA3 function in T cell development is regulated by multiple si
Autor:
Satoru Takahashi, Wataru Nishimura, Kazuki Yasuda, Hisashi Oishi, Nobuaki Funahashi, Toshiyoshi Fujiwara
Publikováno v:
Endocrine Journal. 62:37-51
MafA and MafB are basic leucine zipper transcription factors expressed in mature pancreatic β- and α-cells, respectively. MafA is not only an insulin gene transcription factor but is also critical for the maturation and maintenance of β-cell funct
Autor:
Satoru Takahashi, Margarete M. S. Heck, Jeffrey K Usui, Hisashi Oishi, Yunshin Jung, Ruyi Zhou, Toshiki Kato, Masafumi Muratani
Publikováno v:
Endocrinology. 159(2)
Adenoviral gene transfer of key β cell developmental regulators including Pdx1, Neurod1, and Mafa (PDA) has been reported to generate insulin-producing cells in the liver. However, PDA insulin secretion is transient and glucose unresponsive. Here, w
Publikováno v:
Biochemical and biophysical research communications. 483(1)
The choroid plexus (ChP) is a non-neural epithelial tissue that produces cerebrospinal fluid (CSF). The ChP differentiates from the roof plate, a dorsal midline structure of the neural tube. However, molecular mechanisms underlying ChP development ar
Noninvasive Monitoring of β-Cell Mass and Fetal β-Cell Genesis in Mice Using Bioluminescence Imaging
Autor:
Hisashi Oishi, Satoru Takahashi, Takashi Kudo, Kaori Ikeda, Junya Owada, Yukari Sekiguchi, Tokio Katsumata
Publikováno v:
Experimental animals. 61(4):445-451
Bioluminescence imaging (BLI) has been applied in gene therapy and research to screen for transgene expression, progression of infection, tumor growth and metastasis, and transplantation. It enables real-time and relatively noninvasive localization a