Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Priya Chatterji, Uma M. Sachdeva, Helen Remotti, Rei Mizuno, Kensuke Suzuki, Anil K. Rustgi, Michael P. Verzi, Sepideh Besharati, Yasunori Masuike, Wenping Sun, Sarah F. Andres, Andres J. Klein-Szanto
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Autor:
Timothy Ito, Andres J. Klein-Szanto, Jinfei Xu, Joseph R. Testa, David L. Wiest, Suraj Peri, Eleonora Sementino, Zemin Liu, Yinfei Tan, Kathy Q. Cai, Jianming Pei
Publikováno v:
Oncotarget
// Yinfei Tan 1, * , Eleonora Sementino 1, * , Jinfei Xu 1 , Jianming Pei 1 , Zemin Liu 1 , Timothy K. Ito 1 , Kathy Q. Cai 2 , Suraj Peri 3 , Andres J.P. Klein-Szanto 1, 2 , David L. Wiest 4 , Joseph R. Testa 1 1 Cancer Biology Program, Fox Chase Ca
Autor:
Priya Chatterji, Shun Liang, Premal Shah, Kathryn E. Hamilton, Anil K. Rustgi, Philip Hicks, Christopher J. Lengner, Amanda T. Mah, Jason R. Pitarresi, H. R. Sagara Wijeratne, Laurianne Van Landeghem, Andres J. Klein-Szanto, Brian D. Gregory, Lauren Simon, Sarah F. Andres, Blair B. Madison, Shawn W. Foley, Rei Mizuno
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c9891451436aca7a5c710d79a14e7b
https://europepmc.org/articles/PMC6075153/
https://europepmc.org/articles/PMC6075153/
Autor:
Joseph R. Testa, Jacqueline Talarchek, Erin Neumann-Domer, Deborah A. Altomare, Yue Wu, Craig W. Menges, Guang-Hui Xiao, Vihren N. Kolev, Yuwaraj Kadariya, Irina M. Shapiro, Jonathan A. Pachter, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 74:1261-1271
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbes
Autor:
Barbara Burtness, Linara Gabitova, Tetyana V. Bagnyukova, Gregory P. Adams, Kathy Q. Cai, Hanqing Liu, Yan Zhou, Ilya G. Serebriiskii, Anna Sukhanova, Gail E. Herman, Lisa E. Kratz, David Cunningham, Igor Astsaturov, Ranee Mehra, Richard I. Kelley, Diana Restifo, Erica A. Golemis, Andrey Gorin, Brian L. Egleston, Hui Zheng, Louis M. Weiner, Dong-Hua Yang, Anna S. Nikonova, Andres J. Klein-Szanto
Publikováno v:
Cancer Discovery. 3:96-111
Persistent signaling by the oncogenic EGF receptor (EGFR) is a major source of cancer resistance to EGFR targeting. We established that inactivation of 2 sterol biosynthesis pathway genes, SC4MOL (sterol C4-methyl oxidase–like) and its partner, NSD
Autor:
Jennifer N. Koch, Kathy Q. Cai, David Campbell, J. Silvio Gutkind, Klaus P. Hoeflich, Jonathan Chernoff, Sergio G. Durón, Marie O'Farrell, Dina Stepanova, Zahara M. Jaffer, Andres J. Klein-Szanto, Hoi Yee Chow, Adrian M. Jubb
Publikováno v:
Cancer Research. 72:5966-5975
The RAS genes are the most commonly mutated oncogenes in human cancer and present a particular therapeutic dilemma, as direct targeting of Ras proteins by small molecules has proved difficult. Signaling pathways downstream of Ras, in particular Raf/M
Autor:
Daniel E. Bassi, Tianyu Li, Emmanuelle Nicolas, Jirong Zhang, Andres J. Klein-Szanto, Jian Fu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 4, Pp 271-282 (2012)
Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression. In vitro studies using cancer cell lines and clini
Autor:
Olena Barbash, Anil K. Rustgi, Mariusz A. Wasik, Andres J. Klein-Szanto, Laura Pontano Vaites, Darshan Roy, J A Diehl, Zhaorui Lian, Eric K. Lee
Publikováno v:
Molecular and Cellular Biology. 31:4513-4523
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replicat
Autor:
Heiner Westphal, Zhe-Sheng Chen, Alex Grinberg, Timothy Churchill, Emmanuelle Nicolas, Chelsy Paulose, Andres J. Klein-Szanto, Elizabeth Hopper-Borge, Yehong Kuang, Gary D. Kruh, Martin G. Belinsky, Joely D. Jacobs, Olivia Ngo
Publikováno v:
Cancer Research. 71:3649-3657
Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer resistance to a variety of anticancer agents, including taxanes. However, the in vivo functions of the
Autor:
Andres J. Klein-Szanto, Elizabeth P. Henske, Tiffiney R. Hartman, Emmanuelle Nicolas, Tahseen Al-Saleem, T P Cash, M. C. Simon
Publikováno v:
Oncogene. 28:1594-1604
Birt-Hogg-Dubé (BHD) syndrome is a tumor-suppressor gene disorder characterized by skin tumors, cystic lung disease and renal cell carcinoma. Very little is known about the molecular pathogenesis of BHD. Clinical similarities between BHD and tuberou