Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tsutomu Sasaki"'
Autor:
Shigenobu Matsumura, Motoki Miyakita, Haruka Miyamori, Satomi Kyo, Fuka Ishikawa, Tsutomu Sasaki, Tomoki Jinno, Jin Tanaka, Kotomi Fujita, Takumi Yokokawa, Tsuyoshi Goto, Keiko Momma, Shigeo Takenaka, Kazuo Inoue
Publikováno v:
The FASEB Journal. 36
Melanocortin-4 receptor (MC4R) is a critical regulator of appetite and energy expenditure in rodents and humans. MC4R deficiency causes hyperphagia, reduced energy expenditure, and impaired glucose metabolism. Ligand binding to MC4R activates adenyly
Autor:
Shigenobu Matsumura, Kim Ravnskjaer, Tsuyoshi Goto, Tomoki Jinno, Jin Tanaka, Mike Krogh Terkelsen, Tsutomu Sasaki, Kazuo Inoue, Fuka Ishikawa
Publikováno v:
Matsumura, S, Ishikawa, F, Sasaki, T, Terkelsen, M K, Ravnskjaer, K, Jinno, T, Tanaka, J, Goto, T & Inoue, K 2021, ' Loss of CREB coactivator CRTC1 in SF1 cells leads to hyperphagia and obesity by high-fat diet but not normal chow diet ', Endocrinology, vol. 162, no. 9, bqab076 . https://doi.org/10.1210/endocr/bqab076
Endocrinology
Endocrinology
Cyclic adenosine monophosphate responsive element–binding protein-1-regulated transcription coactivator-1 (CRTC1) is a cytoplasmic coactivator that translocates to the nucleus in response to cyclic adenosine monophosphate. Whole-body knockdown of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c11792fb131fd2a7e19dd00480ad0c8
https://findresearcher.sdu.dk:8443/ws/files/184073250/bqab076.pdf
https://findresearcher.sdu.dk:8443/ws/files/184073250/bqab076.pdf
Autor:
Akihiro Yamanaka, Hiromi Yokota-Hashimoto, Ayumu Inutsuka, Akihiro Harada, Takayoshi Suga, Daisuke Kohno, Tadahiro Kitamura, Masaki Kobayashi, Takashi Nakagawa, Sho Matsui, Tsutomu Sasaki, Tatsushi Onaka, Keisuke Yaku, Osamu Kikuchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetyla
Autor:
Kenichi Todo, Hiroshi Takemori, Kumiko Nishiyama, Tomohiro Kawano, Shigenobu Matsumura, Hideaki Kanki, Shuhei Okazaki, Tsutomu Sasaki, Hideki Mochizuki
Publikováno v:
J Neurosci
The cAMP pathway is known to stabilize endothelial barrier function and maintain vascular physiology. The family of cAMP-response element binding (CREB)-regulated transcription coactivators (CRTC)1–3 activate transcription by targeting the basic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07711f01994e164bdaf9de8884024ca
https://europepmc.org/articles/PMC7724130/
https://europepmc.org/articles/PMC7724130/
Autor:
Jin Tanaka, Fuka Ishikawa, Tomoki Jinno, Motoki Miyakita, Haruka Miyamori, Tsutomu Sasaki, Takumi Yokokawa, Tsuyoshi Goto, Kazuo Inoue, Shigenobu Matsumura
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262577 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262577 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
cAMP responsive element binding protein (CREB)-regulated transcription coactivators (CRTCs) regulate gene transcription in response to an increase in intracellular cAMP or Ca2+ levels. To date, three isoforms of CRTC have been identified in mammals.
Autor:
Tetsuya, Hosooka, Yusei, Hosokawa, Kaku, Matsugi, Masakazu, Shinohara, Yoko, Senga, Yoshikazu, Tamori, Chikako, Aoki, Sho, Matsui, Tsutomu, Sasaki, Tadahiro, Kitamura, Masashi, Kuroda, Hiroshi, Sakaue, Kazuhiro, Nomura, Kei, Yoshino, Yuko, Nabatame, Yoshito, Itoh, Kanji, Yamaguchi, Yoshitake, Hayashi, Jun, Nakae, Domenico, Accili, Takehiko, Yokomizo, Susumu, Seino, Masato, Kasuga, Wataru, Ogawa
Publikováno v:
Proc Natl Acad Sci U S A
Although adipocytes are major targets of insulin, the influence of impaired insulin action in adipocytes on metabolic homeostasis remains unclear. We here show that adipocyte-specific PDK1 (3′-phosphoinositide–dependent kinase 1)-deficient (A-PDK
Autor:
Guoping Fan, Tadahiro Kitamura, Joel K. Elmquist, Matthew Harper, Tsutomu Sasaki, Daisuke Kohno, Ki Woo Kim, Syann Lee, Hideyuki Sone
Publikováno v:
The Journal of Neuroscience. 34:15288-15296
Obesity rates continue to rise throughout the world. Recent evidence has suggested that environmental factors contribute to altered energy balance regulation. However, the role of epigenetic modifications to the central control of energy homeostasis
Autor:
Hye Jin Kim, Osamu Kikuchi, Mayumi Shimpuku, Yong-Soo Lee, Masaki Kobayashi, Tsutomu Sasaki, Vina Yanti Susanti, Sho Matsui, Hiromi Yokota-Hashimoto, Tadahiro Kitamura
Publikováno v:
Obesity (Silver Spring, Md.)
Objective The hypothalamus is the brain center that controls the energy balance. Anorexigenic proopiomelanocortin (POMC) neurons and orexigenic AgRP neurons in the arcuate nucleus of the hypothalamus plays critical roles in energy balance regulation.
Autor:
Toshiko Kajita, Tsutomu Sasaki, Tatsuo Ishizuka, Ichiro Mori, Itaru Kojima, Kazuo Kajita, Takayuki Hanamoto, Hideyuki Okada, Takashi Sato, Taro Usui, Tadahiro Kitamura, Yoshihiko Kitada, Koichiro Taguchi, Hiroyuki Morita, Takahide Ikeda
Publikováno v:
FEBS Letters. 588:1935-1941
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with test
Autor:
Bum-Ho Bin, Takamasa Tsuzuki, Jinhyuk Bhin, Yoshio Fujitani, Shinzaburo Takamiya, Luka Suzuki, Hisashi Naito, Hirotaka Watada, Takeshi Inagaki, Yuri Takamine, Tadahiro Kitamura, Shingo Kajimura, Noriko Ichinoseki-Sekine, Toshiyuki Fukada, Ayako Fukunaka, Toshinori Yoshihara, Takeshi Miyatsuka, Tsutomu Sasaki
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 8, p e1006950 (2017)
PLoS Genetics, Vol 13, Iss 8, p e1006950 (2017)
Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided new insight into human brown adipocyte biology. Genetic mutations in SLC39A13/ZIP13, a membe