Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael J. Kruhlak"'
Autor:
Jin Young Baik, Chamila C. Kadigamuwa, Zhenyu Cai, Jiong Yan, Zheng-gang Liu, Swati Choksi, Michael J. Kruhlak, Hyung-Joon Kwon, Moran Choe, Ross Lake, Delong Jiao, Mayank Tandon, Zhaoshan Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Tumor necrosis happens commonly in advanced solid tumors. We reported that necroptosis plays a major role in tumor necrosis. Although several key necroptosis regulators including receptor interacting protein kinase 1 (RIPK1) have been identified, the
Autor:
Vanja Lazarevic, Yan Wang, Michael J. Kruhlak, Yuanyuan Gao, Jinfang Zhu, Rejane Rua, John Flickinger, Dorian B. McGavern, Brandon Kwong, Eric Vivier
Publikováno v:
Nat Immunol
Nature Immunology
Nature Immunology, 2017, 18 (10), pp.1117+. ⟨10.1038/ni.3816⟩
Nature Immunology, Nature Publishing Group, 2017, 18 (10), pp.1117+. ⟨10.1038/ni.3816⟩
Nature immunology
Nature Immunology
Nature Immunology, 2017, 18 (10), pp.1117+. ⟨10.1038/ni.3816⟩
Nature Immunology, Nature Publishing Group, 2017, 18 (10), pp.1117+. ⟨10.1038/ni.3816⟩
Nature immunology
International audience; The transcription factor T-bet has been associated with increased susceptibility to systemic and organ-specific autoimmunity, but the mechanism by which T-bet expression promotes neuroinflammation remains unknown. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f185c2259742094538c40d38f83ec5b
https://europepmc.org/articles/PMC7416792/
https://europepmc.org/articles/PMC7416792/
Autor:
Anthony J. Adams, Saulius Zuklys, S. Rhiannon Jenkinson, Larry Granger, Gail A. Bishop, Izumi Ohigashi, Joy A. Williams, Jingjing Zhang, Richard J. Hodes, Takeshi Nitta, Georg A. Holländer, Yongwon Choi, Yousuke Takahama, Susan O. Sharrow, Hyein Jeon, Michael J. Kruhlak, Ulrich Siebenlist
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Induction of self-tolerance in developing T cells depends on medullary thymic epithelial cells (mTECs), whose development, in turn, requires signals from single-positive (SP) thymocytes. Thus, the absence of SP thymocytes in Tcra(-/-) mice results in
Autor:
Susan O. Sharrow, Larry Granger, Tullia Lindsten, Craig B. Thompson, François Van Laethem, Xuguang Tai, Terry I. Guinter, Anthony J. Adams, Lionel Feigenbaum, Alfred Singer, Leonid A. Pobezinsky, Michael J. Kruhlak
Publikováno v:
Blood. 119:5155-5163
CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In the present study, we assessed CTLA-4 protein function in both Tregs and conventional (Tcon
Autor:
Michael J. Kruhlak, Oscar Fernandez-Capetillo, R. Daniel Camerini-Otero, Hua-Tang Chen, Yongping Yang, Bernardo Reina San Martin, Michel C. Nussenzweig, Lionel Feigenbaum, Simone Difilippantonio, Arkady Celeste, Galina V. Petukhova, André Nussenzweig, François Van Laethem, Shyam K. Sharan, Katia Manova, Michael Eckhaus
Publikováno v:
Nature Cell Biology. 7:675-685
Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate that Nbs1-null B cells are defective in the activation of ataxia-telangiectasia-mutated (A
Autor:
Michael J. Kruhlak, Richard Baer, Lionel Feigenbaum, Stephen P. Jackson, Robert B. Faryabi, Nancy Wong, Federica Polato, Thomas Ludwig, Hua Tang Chen, Samuel F. Bunting, Colleen R. Reczek, Elsa Callen, André Nussenzweig, Marina L. Kozak, Wen-Hwa Lee
Publikováno v:
The Journal of Experimental Medicine
In contrast to BRCA1, CtIP has indispensable roles in promoting resection and embryonic development.
Homologous recombination (HR) is initiated by DNA end resection, a process in which stretches of single-strand DNA (ssDNA) are generated and use
Homologous recombination (HR) is initiated by DNA end resection, a process in which stretches of single-strand DNA (ssDNA) are generated and use
Autor:
Izumi Ohigashi, Joy A. Williams, Susan O. Sharrow, Anthony J. Adams, Richard J. Hodes, S. Rhiannon Jenkinson, Hyein Jeon, David Klug, Michael J. Kruhlak, Ronald E. Gress, Ellen R. Richie, Yousuke Takahama, Takeshi Nitta, Jingjing Zhang, Baishakhi Choudhury, Michael Eckhaus, Larry Granger
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(2)
A critical process during thymic development of the T cell repertoire is the induction of self-tolerance. Tolerance in developing T cells is highly dependent on medullary thymic epithelial cells (mTEC), and mTEC development in turn requires signals f
Autor:
Bernard Khor, Samuel F. Bunting, Thomas Ried, Michael J. Difilippantonio, Grace K. Mahowald, Nancy Wong, Michael J. Kruhlak, Ching-Yu Huang, André Nussenzweig, Barry P. Sleckman, Elsa Callen
Translocations involving the T cell receptor alpha/delta (TCRalpha/delta) chain locus, which bring oncogenes in the proximity of the TCRalpha enhancer, are one of the hallmark features of human T cell malignancies from ataxia telangiectasia (AT) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9953b2b5f0842d6c9cb666a3fa919d0
https://europepmc.org/articles/PMC3587430/
https://europepmc.org/articles/PMC3587430/
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118311 (2015)
PLoS ONE
PLoS ONE
Members of the SNARE-family of proteins are known to be key regulators of the membrane-membrane fusion events required for intracellular membrane traffic. The ubiquitously expressed SNARE protein SNAP-23 regulates a wide variety of exocytosis events
Autor:
Stephen P. Jackson, Lionel Feigenbaum, Youngsoo Lee, André Nussenzweig, Arkady Celeste, Michael J. Difilippantonio, Peter J. McKinnon, Michael J. Kruhlak, Simone Difilippantonio
Publikováno v:
The Journal of Experimental Medicine
The chromosomal instability syndromes Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) share many overlapping phenotypes, including cancer predisposition, radiation sensitivity, cell-cycle checkpoint defects, immunodeficiency, and gona