Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fuping You"'
Autor:
Ming Kuang, Xuemei Wei, Luoying Chen, Qirui Guo, Yingchi Zhao, Xiu-hong Yang, Lili Cao, Yujie Luo, Xiangxi Wang, Junhong Li, Huawei Xia, Chuan Qin, Fuping You, Linlin Bao, Jiangning Liu, Zeming Zhang, Wei Deng, Nan Wang, Ran Gao, Hua Zhu, Xuefei Guo, Jingxuan Chen, Xiao Wang
Publikováno v:
Cell Host & Microbe
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, the unique signature of early immun
Autor:
Leilei Wang, Duomeng Yang, Tingting Geng, Jesse Hwang, Penghua Wang, Long Yang, Shu Zhu, Harshada Ketkar, Fuping You, Tao Lin, Richard A. Flavell, Erol Fikrig, Jinzhu Ma, Gong Cheng, Jianfeng Dai, Guang Yang, Anthony T. Vella, Yanlin Wang
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Macrophage scavenger receptor 1 (MSR1) mediates the endocytosis of modified low-density lipoproteins and plays an important antiviral role. However, the molecular mechanism underlying MSR1 antiviral actions remains elusive. We report that MSR1 activa
Autor:
Leilei Wang, Gong Cheng, Shuang Cui, Jinzhu Ma, Rongtuan Lin, Fuping You, Long Yang, Harshada Ketkar, Toyoshi Fujimoto, Penghua Wang, Dana G. Mordue, Tingting Geng, Erol Fikrig, Guang Yang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
The ubiquitin regulatory X domain-containing proteins (UBXNs) are likely involved in diverse biological processes. Their physiological functions, however, remain largely unknown. Here we present physiological evidence that UBXN3B positively regulates
Autor:
Xiang Gao, Yunfei Li, Hongqiang Du, Chunxia Jing, Xiaohong Ye, Peng Li, Shengde Liu, Meiling Ou, Fuping You, Feng Shao, Guang Yang, Lili Cao, Siji Li, Baohuan Zhang, Yingchi Zhao, Penghua Wang, Peiyan Wang
Toxoplasma gondii is an important neurotropic pathogen that establishes latent infections in humans that can cause toxoplasmosis in immunocompromised individuals. It replicates inside host cells and has developed several strategies to manipulate host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289775e2fcac04c3781017c8381babce
https://europepmc.org/articles/PMC6851339/
https://europepmc.org/articles/PMC6851339/
Autor:
Penghua Wang, Fuping You, Lili Cao, Guang Yang, Yuxin Yin, Chunxia Jing, Ruth R. Montgomery, Erol Fikrig, Shandian Gao
Publikováno v:
Science signaling. 12(573)
Precise control of interferons (IFNs) is crucial to maintain immune homeostasis. Here, we demonstrated that homeodomain-interacting protein kinase 2 (HIPK2) was required for the production of type I IFNs in response to RNA virus infection. HIPK2 defi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0200385 (2018)
PLoS ONE, Vol 13, Iss 8, p e0200385 (2018)
The innate immune system plays a critical role in the initial antiviral response. However, the timing and duration of these responses must be tightly regulated during infection to ensure appropriate immune cell activation and anti-viral defenses. Her
Autor:
Wenxiang Sun, Lu Chen, Huihui Chen, Glen N. Barber, Fuping You, Delia Gutman, Jing Yang, Hiroki Ishikawa, Hong Tang, Hui Sun, Xiang Zhou, Yutao Wang, Jun Gu, Zhihai Qin, Yukun Guan, Zhengfan Jiang, Weiwei Xia
Publikováno v:
Cell. 147:436-446
SummarySTAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger
Publikováno v:
Nature Immunology. 10:1300-1308
MAVS is critical in innate antiviral immunity as the sole adaptor for RIG-I-like helicases. MAVS regulation is essential for the prevention of excessive harmful immune responses. Here we identify PCBP2 as a negative regulator in MAVS-mediated signali
Autor:
Jim Auer, Richard E. Sutton, Erol Fikrig, Yani Hu, Kaitlin C. O'Boyle, Sagar Raju, Fuping You, Penghua Wang
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 2, p e1006187 (2017)
PLoS Pathogens, Vol 13, Iss 2, p e1006187 (2017)
UBXN proteins likely participate in the global regulation of protein turnover, and we have shown that UBXN1 interferes with RIG-I-like receptor (RLR) signaling by interacting with MAVS and impeding its downstream effector functions. Here we demonstra
Autor:
Yang O. Zhao, Ruth R. Montgomery, Rongtuan Lin, Feng Qian, Long Yang, Akiko Iwasaki, Richard E. Sutton, Erol Fikrig, Guang Yang, Wendy E. Walker, Fuping You, Penghua Wang
Publikováno v:
Nature immunology. 14(12)
Induction of type I interferon is a central event of innate immunity, essential for host defense. Here we report that the transcription factor ELF4 is induced by type I interferon and upregulates interferon expression in a feed-forward loop. ELF4 def