Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Andrew D. Luster"'
Autor:
Thorsten R. Mempel, Philippe Dehio, Andrew D. Luster, Aleksandra J. Ozga, Rachel L. Servis, Mateus E. Lopes, Mauro Di Pilato, Jeffrey Lian, Melvyn T. Chow
Publikováno v:
Immunity
CD8(+) T cells responding to chronic infection adapt an altered differentiation program that provides some restrain on pathogen replication yet limits immunopathology. This adaptation is imprinted in stem-like cells and propagated to their progeny. U
Publikováno v:
Science immunology. 4(35)
Chemoattractant-induced arrest of circulating leukocytes and their subsequent diapedesis is a fundamental component of inflammation. However, how tissue-derived chemoattractants are transported into the blood vessel lumen to induce leukocyte entry in
Autor:
Joao Incio, Dai Fukumura, Keehoon Jung, Yuhui Huang, Rakesh K. Jain, Elizabeth Beech, Matthias Pinter, Jeffrey W. Clark, Andrew D. Luster, Jun Ki Kim, Christopher G. Willett, Timothy P. Padera, Kosuke Kawaguchi, Seok Hyun Yun, Nuh N. Rahbari, William Ho, Takahiro Heishi, Euiheon Chung
Antiangiogenic therapy with antibodies against VEGF (bevacizumab) or VEGFR2 (ramucirumab) has been proven efficacious in colorectal cancer (CRC) patients. However, the improvement in overall survival is modest and only in combination with chemotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811d7862e7b31c7419e6a2b0ebcbab1d
https://europepmc.org/articles/PMC5625928/
https://europepmc.org/articles/PMC5625928/
Publikováno v:
Immunity. 49(3)
Summary The migration of mature dendritic cells (DCs) into the draining lymph node (dLN) is thought to depend solely on the chemokine receptor CCR7. CD301b+ DCs migrate into the dLN after cutaneous allergen exposure and are required for T helper 2 (T
Autor:
Jennifer A. Lo, Melvyn T. Chow, Aleksandra J. Ozga, Genevieve M. Boland, Dennie T. Frederick, David E. Fisher, Andrew D. Luster, Gordon J. Freeman, Rachel L. Servis
Publikováno v:
Immunity
Summary Despite compelling rates of durable clinical responses to programmed cell death-1 (PD-1) blockade, advances are needed to extend these benefits to resistant tumors. We found that tumor-bearing mice deficient in the chemokine receptor CXCR3 re
Autor:
Terry K. Means, Tal Iram, William F. Pendergraft, Joseph El Khoury, Nir Hacohen, Zaida G. Ramirez-Ortiz, Amit Prasad, Christopher J Blanchette, Andrew D. Luster, Michael H. Byrne
Publikováno v:
Nature immunology
The clearance of apoptotic cells is critical for the control of tissue homeostasis; however, the full range of receptors on phagocytes responsible for the recognition of apoptotic cells remains to be identified. Here we found that dendritic cells (DC
Autor:
Andrew D. Luster, Norihiko Sakai, Takashi Wada, Jeremy S. Duffield, Andrew M. Tager, Jerold Chun
Publikováno v:
The FASEB Journal. 27:1830-1846
There has been much recent interest in lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, in fibrotic diseases, but the mechanisms by which LPA-LPA1 signaling promotes pathological fibrosis remain to be fully elucidated. Using
Immunotherapies have shown considerable efficacy for the treatment of various cancers, but a multitude of patients remain unresponsive for various reasons, including poor homing of T cells into tumors. In this study, we investigated the roles of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc171098af925fce72d0af26c45df34
https://europepmc.org/articles/PMC4992661/
https://europepmc.org/articles/PMC4992661/
Publikováno v:
Journal of leukocyte biology. 102(1)
LPS is a powerful adjuvant, and although LPS-mediated TLR4 signaling has been exquisitely delineated, the in vivo mechanism of how TLR4 responses impact T cell priming is far less clear. Besides costimulation, TNF and type 1 IFN are dominant cytokine
Publikováno v:
Methods in enzymology. 570
Chemokines regulate the migration of cells in vivo and dysregulated expression of chemokines and their receptors are implicated in autoimmune and inflammatory diseases. Inflammatory arthritides, such as rheumatoid arthritis (RA), are characterized by