Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Shimon, Sakaguchi"'
Publikováno v:
Proc Natl Acad Sci U S A
Foxp3-expressing CD4(+)CD25(+) regulatory T cells (Tregs) constitutively and highly express the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), whose Treg-specific deficiency causes severe systemic autoimmunity. As a
Autor:
Tomoyuki Yamaguchi, Shunsuke Teraguchi, Chikara Furusawa, Tomonobu M. Watanabe, Shimon Sakaguchi, Toshio Yanagida, Hiroaki Machiyama, Hideaki Fujita
Publikováno v:
International Immunology
A novel mechanism for Treg-mediated control of immune responses
The immune system in tolerance maintains cell diversity without responding to self-antigens. Foxp3-expressing CD25+CD4+ regulatory T cells (Tregs) inhibit T-cell activation through
The immune system in tolerance maintains cell diversity without responding to self-antigens. Foxp3-expressing CD25+CD4+ regulatory T cells (Tregs) inhibit T-cell activation through
Autor:
Soichiro Yamanaka, Yohko Kitagawa, Hiroko Nakatsukasa, Jinghua Yin, Mayumi Oda, Shimon Sakaguchi, Mana Koga-Iizuka, Yu Ichi Tsukada, Akihiko Yoshimura, Qianjin Lu, Naganari Ohkura, Jun Kohyama, Minako Ito, Ikuko Koya, Takeji Takamura-Enya, Shunsuke Chikuma, Tsukasa Sanosaka, Kazue Someya
Publikováno v:
International Immunology. 31:335-347
Ten-eleven translocation (TET) proteins regulate DNA methylation and gene expression by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Although Tet2/Tet3 deficiency has been reported to lead to myeloid cell, B-cell and invariant
Autor:
Yohko Kitagawa, Keiko Yasuda, Norihisa Mikami, Masaya Arai, Hitomi Watanabe, Kelvin Y. Chen, Gen Kondoh, Daiya Ohara, Motonao Osaki, Yamami Nakamura, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi, Ryoji Kawakami, Caleb A. Lareau
Publikováno v:
Immunity. 54(5)
The transcription factor Foxp3 plays crucial roles for Treg cell development and function. Conserved non-coding sequences (CNSs) at the Foxp3 locus control Foxp3 transcription, but how they developmentally contribute to Treg cell lineage specificatio
Autor:
Jose G. Vilches-Moure, Miranda Byrne-Steele, Qing Min, Ji-Yang Wang, Zhihai Ma, Guang Qin, Christian Toonstra, Chunlin Wang, Yang Yang, Xiao Li, Rongjian Hong, Michael Snyder, James B. Wing, Yong Cheng, Jian Han, Leonore A. Herzenberg, Lai-Xi Wang, Gao Zhou, Shimon Sakaguchi, Denong Wang, Justin Youngyunpipatkul, Qunying Yang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
CTLA-4 is an important regulator of T-cell function. Here, we report that expression of this immune-regulator in mouse B-1a cells has a critical function in maintaining self-tolerance by regulating these early-developing B cells that express a repert
Autor:
Radhika Goenka, Fabien Dépis, Julie B. Engiles, Christophe Benoist, Michael P. Cancro, Daniel P. Beiting, Dorothy Cimino Brown, Christoph Konradt, Christopher A. Hunter, Sunglim Cho, Li-Fan Lu, James B. Wing, Jonathan S. Silver, Daniela Gómez Atria, Jan Erikson, Shimon Sakaguchi, William J. Quinn, Arielle Glatman Zaretsky, David Allman, Amaya I. Wolf
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1906-1916 (2017)
Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the factors that control PCs. We found that systemic infection alters the BM, greatly reducing PCs an
Autor:
Yohko Kitagawa, Gen Kondoh, Shimon Sakaguchi, Hitomi Watanabe, Terumi Kohwi-Shigematsu, Keiji Hirota, Ryoji Kawakami, Yoshitaka Isaka, Keiko Yasuda
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
The genome organizer, special AT-rich sequence-binding protein-1 (Satb1), plays a pivotal role in the regulation of global gene networks in a cell type-dependent manner and is indispensable for the development of multiple cell types, including mature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791b0e44824bd387baa6b5c9024644c2
https://escholarship.org/uc/item/0qp0f1kn
https://escholarship.org/uc/item/0qp0f1kn
Autor:
Masahiko, Akamatsu, Norihisa, Mikami, Naganari, Ohkura, Ryoji, Kawakami, Yohko, Kitagawa, Atsushi, Sugimoto, Keiji, Hirota, Naoto, Nakamura, Satoru, Ujihara, Toshio, Kurosaki, Hisao, Hamaguchi, Hironori, Harada, Guliang, Xia, Yoshiaki, Morita, Ichiro, Aramori, Shuh, Narumiya, Shimon, Sakaguchi
Publikováno v:
Cell Mol Immunol
A promising way to restrain hazardous immune responses, such as autoimmune disease and allergy, is to convert disease-mediating T cells into immunosuppressive regulatory T (T
Autor:
Takashi, Matsuo, Motomu, Hashimoto, Shimon, Sakaguchi, Noriko, Sakaguchi, Yoshinaga, Ito, Masaki, Hikida, Tatsuaki, Tsuruyama, Kaoru, Sakai, Hideki, Yokoi, Mirei, Shirakashi, Masao, Tanaka, Hiromu, Ito, Hajime, Yoshifuji, Koichiro, Ohmura, Takao, Fujii, Tsuneyo, Mimori
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 202(11)
A defect in TCR-proximal signaling is a major characteristic of CD4 T cells in systemic lupus erythematosus; however, it is not fully known how defects in TCR signaling lead to lupus-like systemic autoimmunity characterized by germinal center develop
Autor:
Tomohiro Kurosaki, Axel Kallies, Stephen L. Nutt, Hiroyoshi Nishikawa, Shimon Sakaguchi, Kiyoshi Takeda, Yoshihiro Baba, Akemi Baba, Yasuyuki Ohkawa, Takafumi Yokota, Hisako Kayama, Masanori Matsumoto
Publikováno v:
Immunity. 41(6):1040-1051
SummaryB cells can suppress autoimmunity by secreting interleukin-10 (IL-10). Although subpopulations of splenic B lineage cells are reported to express IL-10 in vitro, the identity of IL-10-producing B cells with regulatory function in vivo remains