Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sabine M. Hölter"'
Autor:
Kan Xie, Helmut Fuchs, Enzo Scifo, Dan Liu, Ahmad Aziz, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Patricia da Silva-Buttkus, Julia Calzada-Wack, Yi-Li Cho, Yushuang Deng, A. Cole Edwards, Lillian Garrett, Christina Georgopoulou, Raffaele Gerlini, Sabine M. Hölter, Tanja Klein-Rodewald, Michael Kramer, Stefanie Leuchtenberger, Dimitra Lountzi, Phillip Mayer-Kuckuk, Lena L. Nover, Manuela A. Oestereicher, Clemens Overkott, Brandon L. Pearson, Birgit Rathkolb, Jan Rozman, Jenny Russ, Kristina Schaaf, Nadine Spielmann, Adrián Sanz-Moreno, Claudia Stoeger, Irina Treise, Daniele Bano, Dirk H. Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Beverly A. Mock, Paolo Salomoni, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Monique M. B. Breteler, Martin Hrabě de Angelis, Dan Ehninger
Publikováno v:
Nature Communications, 13(1):6830
Nature Communications 13(1), 6830 (2022). doi:10.1038/s41467-022-34515-y
Nat. Commun. 13:6830 (2022)
Nature Communications 13(1), 6830 (2022). doi:10.1038/s41467-022-34515-y
Nat. Commun. 13:6830 (2022)
SummaryCurrent concepts regarding the biology of aging are based on studies aimed at identifying factors regulating natural lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d257d56a9096dee85263597bab592d8
https://doi.org/10.1101/2022.03.25.485824
https://doi.org/10.1101/2022.03.25.485824
Autor:
Tamara Heermann, Jochen Graw, Wolfgang Wurst, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Sabine M. Hölter, Lillian Garrett
Publikováno v:
Mol. Neurobiol. 56, 4215-4230 (2019)
Molecular neurobiology 56(6), 4215-4230 (2018). doi:10.1007/s12035-018-1365-5
Molecular neurobiology 56(6), 4215-4230 (2018). doi:10.1007/s12035-018-1365-5
As part of the -superfamily, B2-crystallin (CRYBB2) is an ocular structural protein in the lens, and mutation of the corresponding gene can cause cataracts. CRYBB2 also is expressed in non-lens tissue such as the adult mouse brain and is associated w
Autor:
Martin Hrabĕ de Angelis, Jochen Graw, Ute Rößler, Gregor Miller, Daniela M. Vogt Weisenhorn, Horst Zitzelsberger, Marie-Claire Ung, Wolfgang Wurst, Daniel Dragosa, Claudia Dalke, Sabine M. Hölter, Frauke Neff, Lillian Garrett, Daniela Hladik, Florian Wagner, Valentin Leitner
Publikováno v:
Int. J. Radiat. Biol. 97, 156-169 (2021)
International journal of radiation biology 97(2), 156-169 (2021). doi:10.1080/09553002.2021.1857455
International journal of radiation biology 97(2), 156-169 (2021). doi:10.1080/09553002.2021.1857455
Purpose: The increasing use of low-dose ionizing radiation in medicine requires a systematic study of its long-term effects on the brain, behaviour and its possible association with neurodegenerative disease vulnerability. Therefore, we analysed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297296c60538e74b7d85958f4b23df61
Autor:
Joanna Segal, Lillian Garrett, Manuela Scholze-Wittler, Dirk H. Busch, Bernd Timmermann, Eckhard Wolf, Markus Ralser, Thure Adler, Nana-Maria Grüning, Martin Hrabě de Angelis, Helmut Fuchs, Jan Rozman, Thomas Klopstock, Antje Krüger, Julia Calzada-Wack, Michael Mülleder, Sabine M. Hölter, Steve Michel, Hans Lehrach, Ingo Voigt, Ludger Hartmann, Mariia Yuneva, Frauke Neff, Ildiko Racz, Lore Becker, Martin Klingenspor, Ralf Fischer, Wolfgang Wurst, Heinrich Schrewe, Valerie Gailus-Durner, Beata Lukaszewska‐McGreal, Birgit Rathkolb
Publikováno v:
Journal of Inherited Metabolic Disease
Journal of inherited metabolic disease 42(5), 839-849 (2019). doi:10.1002/jimd.12105
J. Inherit. Metab. Dis. 42, 839-849 (2019)
Journal of inherited metabolic disease 42(5), 839-849 (2019). doi:10.1002/jimd.12105
J. Inherit. Metab. Dis. 42, 839-849 (2019)
Triosephosphate isomerase (TPI) deficiency is a fatal genetic disorder characterized by hemolytic anemia and neurological dysfunction. Although the enzyme defect in TPI was discovered in the 1960s, the exact etiology of the disease is still debated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc9b7daee234fa033a69f5666742a4f
https://mediatum.ub.tum.de/doc/1539484/document.pdf
https://mediatum.ub.tum.de/doc/1539484/document.pdf
Autor:
Dirk H. Busch, Jan Rozman, Robert Brommage, Helmut Fuchs, Raffi Bekeredjian, Lillian Garrett, Sabine M. Hölter, Anton Wellstein, Julia Calzada-Wack, Holger Maier, T. Klopstock, Ralph Steinkamp, Yong Gu Lee, Johannes Beckers, Marion Horsch, Patrick James Beck, Martin Hrabé de Angelis, Khalid Garman, Carsten B. Schmidt-Weber, Annemarie Zimprich, Claudia Stoeger, Marcel O. Schmidt, L. Becker, Eckhard Wolf, Thure Adler, Jochen Graw, Chong Zuo, Ildiko Racz, Irina Treise, Andreas Zimmer, Alexandra Vernaleken, Juan Antonio Aguilar-Pimentel, Wolfgang Hans, Wolfgang Wurst, Mingjun Tan, Stefanie Leuchtenberger, Christoph Lengger, Martin Klingenspor, Patricia da Silva-Buttkus, Elena Tassi, Anna T. Riegel, Valerie Gailus-Durner, Birgit Rathkolb, Manuela A. Östereicher, Markus Ollert, Kristin Moreth, Frauke Neff, Oana V. Amarie
Publikováno v:
J. Invest. Dermatol. 138, 179-188 (2018)
Schmidt, M O, Garman, K A, Lee, Y G, Zuo, C, Beck, P J, Tan, M, Aguilar-Pimentel, J A, Ollert, M, Schmidt-Weber, C, Fuchs, H, Gailus-Durner, V, Hrabe de Angelis, M, Tassi, E, Riegel, A T, Wellstein, A & German Mouse Clinic Consortium 2018, ' The Role of Fibroblast Growth Factor Binding Protein 1 in Skin Carcinogenesis and Inflammation ', Journal of Investigative Dermatology, vol. 138, no. 1, pp. 179-188 . https://doi.org/10.1016/j.jid.2017.07.847
Schmidt, M O, Garman, K A, Lee, Y G, Zuo, C, Beck, P J, Tan, M, Aguilar-Pimentel, J A, Ollert, M, Schmidt-Weber, C, Fuchs, H, Gailus-Durner, V, Hrabe de Angelis, M, Tassi, E, Riegel, A T, Wellstein, A & German Mouse Clinic Consortium 2018, ' The Role of Fibroblast Growth Factor Binding Protein 1 in Skin Carcinogenesis and Inflammation ', Journal of Investigative Dermatology, vol. 138, no. 1, pp. 179-188 . https://doi.org/10.1016/j.jid.2017.07.847
Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef892b21438e575f4ff4729d8cf2a25
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51790
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51790
Autor:
Andreas W. Kuss, Ildiko Racz, Lore Becker, Thomas Klopstock, Lillian Garrett, Lars R. Jensen, Markus Ralser, Jozef Gecz, Martin Hrabě de Angelis, Matthias Rath, Hans-Hilger Ropers, Martin Klingenspor, Eckhard Wolf, Juan Antonio Aguilar-Pimentel, Thure Adler, Wolfgang Wurst, Anke Van Dijck, Sabine Müller, Jan Rozman, Viola von Bohlen und Halbach, Andreas Zimmer, Kristin Moreth, Harry Scherthan, Katharina Blümlein, Martin B. Delatycki, Birgit Rathkolb, Diego J. Walther, Jochen Graw, R. Frank Kooy, Jerzy Adamski, Valerie Gailus-Durner, Oliver Puk, Helmut Fuchs, Sabine M. Hölter, Bettina Bert, Oliver von Bohlen und Halbach, Cornelia Prehn, Wolfgang Hans, Zornitza Stark, Monika Dopatka, Dirk H. Busch, Heidrun Fink
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Biochimica et biophysica acta : molecular basis of disease
Biochimica et biophysica acta / Molecular basis of disease 1865(9), 2083-2093 (2019). doi:10.1016/j.bbadis.2018.12.011
Biochimica et biophysica acta : molecular basis of disease
Biochimica et biophysica acta / Molecular basis of disease 1865(9), 2083-2093 (2019). doi:10.1016/j.bbadis.2018.12.011
Mutations in the X chromosomal tRNA 2'-O-methyltransferase FTSJ1 cause intellectual disability (ID). Although the gene is ubiquitously expressed affected individuals present no consistent clinical features beyond ID. In order to study the pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7c5352c82f2abde8ba3f3cd43a40d0
https://hdl.handle.net/21.11116/0000-0003-587A-221.11116/0000-0003-587C-0
https://hdl.handle.net/21.11116/0000-0003-587A-221.11116/0000-0003-587C-0
Autor:
Juha Saarikangas, Geneviève Chazal, Lore Becker, Valerie Gailus-Durner, Yosuke Senju, Rimante Minkeviciene, Thomas Klopstock, Martin Hrabě de Angelis, Lotta von Ossowski, Tomi Taira, Helmut Fuchs, Wolfgang Hans, Lillian Garrett, Sabine M. Hölter, Andreas Zimmer, Nazim Kourdougli, Pirta Hotulainen, Claudio Rivera, Ildiko Racz, Jaakko Kuurne, Pieta K. Mattila, Wolfgang Wurst, Mikael Segerstråle, Pekka Lappalainen
Publikováno v:
Dev. Cell 33, 644-659 (2015)
Developmental cell 33(6), 644-659 (2015). doi:10.1016/j.devcel.2015.04.014
Developmental cell 33(6), 644-659 (2015). doi:10.1016/j.devcel.2015.04.014
SummaryProper morphogenesis of neuronal dendritic spines is essential for the formation of functional synaptic networks. However, it is not known how spines are initiated. Here, we identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of
Autor:
Michael A. Sandholzer, Raffi Bekeredjian, Jan Rozman, Helmut Fuchs, Thomas Klopstock, Dirk H. Busch, Juan Antonio Aguilar-Pimentel, Wolfgang Wurst, Dirk Janik, Lore Becker, Marco Weiergräber, Valerie Gailus-Durner, Martin Hrabě de Angelis, Oana V. Amarie, Brandon L. Pearson, Isabelle Lehmann, Jochen Graw, Susanne Schröder, Robert Brommage, Carsten B. Schmidt-Weber, Kan Xie, Sabine M. Hölter, Gerhard Ehninger, Andreas Zimmer, Lillian Garrett, Irina Treise, Birgit Rathkolb, Eckhard Wolf, Ildiko Racz, Kristin S. Henzel, Martin Klingenspor, Dan Ehninger, Astrid Markert, Kristin Moreth, Frauke Neff, Devon Ryan, Markus Ollert
Publikováno v:
Nature Communications, 8:155
Xie, K, Neff, F, Markert, A, Rozman, J, Aguilar-Pimentel, J A, Amarie, O V, Becker, L, Brommage, R, Garrett, L, Henzel, K S, Hölter, S M, Janik, D, Lehmann, I, Moreth, K, Pearson, B L, Racz, I, Rathkolb, B, Ryan, D P, Schröder, S, Treise, I, Bekeredjian, R, Busch, D H, Graw, J, Ehninger, G, Klingenspor, M, Klopstock, T, Ollert, M, Sandholzer, M, Schmidt-Weber, C, Weiergräber, M, Wolf, E, Wurst, W, Zimmer, A, Gailus-Durner, V, Fuchs, H, Hrabě de Angelis, M & Ehninger, D 2017, ' Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice ', Nature Communications, vol. 8, 155 . https://doi.org/10.1038/s41467-017-00178-3
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Nat. Commun. 8:155 (2017)
Nature Communications 8(1), 155 (2017). doi:10.1038/s41467-017-00178-3
Xie, K, Neff, F, Markert, A, Rozman, J, Aguilar-Pimentel, J A, Amarie, O V, Becker, L, Brommage, R, Garrett, L, Henzel, K S, Hölter, S M, Janik, D, Lehmann, I, Moreth, K, Pearson, B L, Racz, I, Rathkolb, B, Ryan, D P, Schröder, S, Treise, I, Bekeredjian, R, Busch, D H, Graw, J, Ehninger, G, Klingenspor, M, Klopstock, T, Ollert, M, Sandholzer, M, Schmidt-Weber, C, Weiergräber, M, Wolf, E, Wurst, W, Zimmer, A, Gailus-Durner, V, Fuchs, H, Hrabě de Angelis, M & Ehninger, D 2017, ' Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice ', Nature Communications, vol. 8, 155 . https://doi.org/10.1038/s41467-017-00178-3
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Nat. Commun. 8:155 (2017)
Nature Communications 8(1), 155 (2017). doi:10.1038/s41467-017-00178-3
Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc795284ebf23c25ba94f2eee70a5ada
https://www.nature.com/articles/s41467-017-00178-3#Sec52
https://www.nature.com/articles/s41467-017-00178-3#Sec52
Autor:
Thomas Klopstock, Jerzy Adamski, Christopher Meyer zu Reckendorf, Sofia Anastasiadou, Eckhard Wolf, Martin Klingenspor, Valerie Gailus-Durner, Martin Hrabé de Angelis, Wolfgang Wurst, Lillian Garrett, Annemarie Zimprich, Sabine M. Hölter, Gabi Mroz, Kristin Moreth, Birgit Rathkolb, Jan Rozman, Bernd Knöll, Cornelia Prehn, Helmut Fuchs, Lore Becker, Raffi Bekeredjian, Philip Förstner
Publikováno v:
Molecular neurobiology 54(10), 8242-8262 (2016). doi:10.1007/s12035-016-0300-x
ResearcherID
ResearcherID
Stress experience modulates behavior, metabolism, and energy expenditure of organisms. One molecular hallmark of an acute stress response is a rapid induction of immediate early genes (IEGs) such as c-Fos and Egr family members. IEG transcription in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caee722411609b5a48d9b6414900d5b
Autor:
Martin Hrabé de Angelis, Tania F. Gendron, Leda Dimou, Benedikt Schoser, Meike Michaelsen, Qihui Zhou, Leonard Petrucelli, Bastian Popper, Tim M. Strom, Marianne Dieterich, Jing Tan, Juliane Winkelmann, Martin H. Schludi, Kristin Rentzsch, Wolfgang Wurst, Helmut Fuchs, Sabine M. Hölter, Stephanie May, Anne von Thaden, Franziska Schreiber, Lore Becker, Valerie Gailus-Durner, Thomas Arzberger, Lillian Garrett, Dieter Edbauer, Benjamin M. Schwenk, Thomas Klopstock
Publikováno v:
Acta neuropathologica 134(2), 241-254 (2017). doi:10.1007/s00401-017-1711-0
Acta Neuropathologica
Acta Neuropathol. 134, 241–254 (2017)
Acta Neuropathologica
Acta Neuropathol. 134, 241–254 (2017)
Translation of the expanded (ggggcc)n repeat in C9orf72 patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) causes abundant poly-GA inclusions. To elucidate their role in pathogenesis, we generated transgenic mice expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec457c586cd5b2ad17c58ea04d04338
https://pub.dzne.de/record/139375
https://pub.dzne.de/record/139375