Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Raghavendra G. Mirmira"'
Publikováno v:
J Diabetes Complications
Background Obesity and the metabolic syndrome are increasingly prevalent in society and their complications and response to treatment exhibit sexual dimorphism. Mouse models of high fat diet-induced obesity are commonly used for both mechanistic and
Autor:
Clarissa Hernandez Stephens, J. Catharine Scott-Moncrieff, Sherry L. Voytik-Harbin, Raghavendra G. Mirmira, Robert V. Considine, Kara S. Orr, Madeline McLaughlin, Sarah A. Tersey, Rachel A. Morrison
Publikováno v:
Am J Physiol Endocrinol Metab
Replacement of islets/β-cells that provide long-lasting glucose-sensing and insulin-releasing functions has the potential to restore extended glycemic control in individuals with type 1 diabetes. Unfortunately, persistent challenges preclude such th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbc86aff6998a2a20de3764f5dbce98
https://europepmc.org/articles/PMC7473915/
https://europepmc.org/articles/PMC7473915/
Autor:
Christien B. Dykstra, Bozena Samborska, Caroline S. Jiang, Paul Cohen, Lawrence Kazak, Olivia A. Maguire, Janane F. Rahbani, Matthew G. Annis, Xiaojing Huang, Adriana Rosas-Villegas, Sarah K. Szwed, Rebecca G. Gelfer, Peter M. Siegel, François Marchildon, Ji Dung Luo, Raghavendra G. Mirmira, Daniel J. Kramer, Sarah E. Ackerman, Aarthi V. Maganti, Victor Ceballos, Lauren E. Turner, Sarah A. Tersey, Andrew J. Dannenberg, Thomas L. Carroll, Asal Hejazi
Publikováno v:
Cell metabolism. 33(3)
Obesity is a major risk factor for adverse outcomes in breast cancer; however, the underlying molecular mechanisms have not been elucidated. To investigate the role of crosstalk between mammary adipocytes and neoplastic cells in the tumor microenviro
Autor:
Adolfo Garcia-Ocaña, Bernhard Maier, Donald K. Scott, Teresa L. Mastracci, Laura C. Alonso, Esther M. Levasseur, Raghavendra G. Mirmira, Farooq Syed, Emily Anderson-Baucum, Sarah A. Tersey, Amber L. Mosley, Annie R. Piñeros, Kara S. Orr, Kentaro Yamada, Wenting Wu, Ernesto Bernal-Mizrachi, Yunlong Liu
Publikováno v:
Sci Signal
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230627 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230627 (2020)
The gene encoding eukaryotic initiation factor 5A (EIF5A) is found in diabetes-susceptibility loci in mouse and human. eIF5A is the only protein known to contain hypusine (hydroxyputrescine lysine), a polyamine-derived amino acid formed post-translat
Autor:
John E. Cupit, Raghavendra G. Mirmira, Abass M. Conteh, Amelia K. Linnemann, Michelle Marasco, Evan M. Appleman, Christopher A. Reissaus
Publikováno v:
Diabetes
Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell autophagy but has not been studied in the context of β-cell antio
Publikováno v:
Amino Acids. 46:633-642
The underlying pathophysiology of type 1 diabetes involves autoimmune-mediated islet inflammation, leading to dysfunction and death of insulin-secreting islet β cells. Recent studies have shown that polyamines, which are essential for mRNA translati
Publikováno v:
Molecular Endocrinology. 27:162-171
The increased insulin secretory burden placed on pancreatic β-cells during obesity and insulin resistance can ultimately lead to β-cell dysfunction and death and the development of type 2 diabetes. Mitogen-inducible gene 6 (Mig6) is a cellular stre
Autor:
Medha Priyadarshini, Anthony R. Angueira, Maureen Gannon, Sarah A. Tersey, Miles Fuller, Bethany A. Carboneau, Tanya Bhardwaj, Annette Gilchrist, Raghavendra G. Mirmira, Rockann E. Mosser, Brian T. Layden, Michael R. Brodsky, Stephanie R. Villa, Helena Mancebo
Publikováno v:
Scientific Reports
The regulation of pancreatic β cell mass is a critical factor to help maintain normoglycemia during insulin resistance. Nutrient-sensing G protein-coupled receptors (GPCR) contribute to aspects of β cell function, including regulation of β cell ma
Autor:
Raghavendra G. Mirmira, Anna M. Castle, Laura C. Page, Catherine C. Hedrick, Anthony P. Trace, John S. Parks, Carmella Evans-Molina, Jeffrey M. Sturek, J. David Castle
Publikováno v:
Journal of Clinical Investigation. 120:2575-2589
Cholesterol is a critical component of cell membranes, and cellular cholesterol levels and distribution are tightly regulated in mammals. Recent evidence has revealed a critical role for pancreatic beta cell-specific cholesterol homeostasis in insuli