Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jianjun Zhong"'
Autor:
Wei Tang, Weina Chai, Donglin Du, Yongzhi Xia, Yifan Wu, Li Jiang, Chongjie Cheng, Zongduo Guo, Xiaochuan Sun, Zhijian Huang, Jianjun Zhong
Publikováno v:
Oxidative Medicine and Cellular Longevity.
We previously discovered that traumatic brain injury (TBI) induces significant perturbations in long noncoding RNA (lncRNA) levels in the mouse cerebral cortex, and lncRNA-AK046375 is one of the most significantly changed lncRNAs after TBI. lncRNA-AK
Autor:
Jianhua Peng, Zhijian Huang, Cheng Yin, Yue Wu, Jianjun Zhong, Li Jiang, Chongjie Cheng, Xiaochuan Sun, Yong Jiang, Fang Cao, Zongduo Guo
Publikováno v:
CNS Neuroscience & Therapeutics
Introduction Axonal injury results in long‐term neurological deficits in traumatic brain injury (TBI) patients. Apolipoprotein E (ApoE) has been reported to activate intracellular adaptor protein Disabled‐1 (Dab1) phosphorylation via its interact
Autor:
Zhaosi Zhang, Xiaochuan Sun, Zhijian Huang, Chongjie Cheng, Jingchuan Wu, Liu Liu, Hui Li, Junchi He, Li Jiang, Zongduo Guo, Yue Wu, Jianjun Zhong, Hongrong Zhang, Lingjun Qi, Han Liu
Publikováno v:
Neurobiology of Disease, Vol 117, Iss, Pp 114-124 (2018)
Traumatic brain injury (TBI) causes a high rate of mortality and disability worldwide, and there exists almost none effective drugs to protect against TBI. Neurotoxicity occurring after TBI can be derived from microglia and astrocytes, and causes neu
Autor:
Yike Huang, Zhaosi Zhang, Xiaochuan Sun, Zhijian Huang, Zongduo Guo, Liu Liu, Li Jiang, Shaoqiu Jiang, Chongjie Cheng, Jianjun Zhong, Jingchuan Wu, Han Liu, Junchi He, Chao Zhou
Publikováno v:
Experimental neurology. 334
Traumatic brain injury (TBI) has been regarded as one of the leading cause of injury-related death and disability. White matter injury after TBI is characterized by axon damage and demyelination, resulting in neural network impairment and neurologica
Autor:
Yue Wu, Liu Liu, Rui Xu, Zhaosi Zhang, Han Liu, Xiaochuan Sun, Zongduo Guo, Wei-na Chai, Hongrong Zhang, Junchi He, Chongjie Cheng, Li Jiang, Zhijian Huang, Gang Huo, Jianjun Zhong
Publikováno v:
International Journal of Medical Sciences
Background: As a major antioxidant in serum, uric acid (UA) was once considered only as the leading cause of gout; however, recent studies have validated its neuroprotective role in ischemic stroke. Because the potential protective effects of UA in t
Autor:
Xiaochuan Sun, Zongduo Guo, Zhijian Huang, Jianjun Zhong, Li Jiang, Chongjie Cheng, Fang Cao, Zhanyang Yu
Publikováno v:
Journal of Neurochemistry. 136:1017-1025
Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in youth, but to date, effective therapies are still lacking. Previous studies revealed a marked response of apolipoprotein J (ApoJ) expression to the brain injury. The aim
Autor:
Chongjie Cheng, Yue Wu, Junqing Yang, Xiaocui Tian, Zhijian Huang, Xiaochuan Sun, Zongduo Guo, Hong Wang, Jianjun Zhong, Li Jiang, Rami Darwazeh, Zhihao Chen
Publikováno v:
Experimental neurology. 313
Background and objective Circular RNA (circRNA) is an important type of non-coding RNA that has not been widely researched in traumatic brain injury (TBI). The present study aimd to detect the altered circRNA expression around an injury site in the m
Autor:
Rami Darwazeh, Li Jiang, Xiaochuan Sun, Han Liu, Jianjun Zhong, Chongjie Cheng, Jingchuan Wu, Junchi He, Yue Wu, Hongrong Zhang, Zhijian Huang
Publikováno v:
Brain, behavior, and immunity. 65
Objective Bexarotene treatments exert neuroprotective effects on mice following traumatic brain injury (TBI). The present study aims to investigate the potential roles of the long noncoding RNA Neat1 in the neuroprotective effects of bexarotene. Mate
Autor:
Hongrong Zhang, Xiaochuan Sun, Li Jiang, Jianjun Zhong, Zhijian Huang, Yong Jiang, Chongjie Cheng, Jianhua Peng, Junchi He, Han Liu, Fang Cao
Publikováno v:
Brain research. 1646
The present study aims to detect the altered lncRNA expression in the mouse cortex after traumatic brain injury (TBI). We also simultaneously detected the altered mRNA profile to further analyze the possible function of lncRNA.C57BL/6 mice (n=18) wer
Autor:
Jianjun Zhong, Xiaochuan Sun, Junchi He, Li Jiang, Yue Wu, Chongjie Cheng, Hongrong Zhang, Han Liu, Zhijian Huang, Zhipeng Teng, Fang Cao, Jinchuan Wu
Publikováno v:
Neuroscience. 343
Bexarotene has been proved to have neuroprotective effects in many animal models of neurological diseases. However, its neuroprotection in traumatic brain injury (TBI) is still unknown. This study aims to explore the neuroprotective effects of bexaro