Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Fuping You"'
Publikováno v:
The Journal of Immunology. 204:1904-1918
IFN regulatory factor 3 (IRF3) is critical for the transcription of type I IFNs in defensing virus and promoting inflammatory responses. Although several kinds of posttranslational modifications have been identified to modulate the activity of IRF3,
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4825
Alcohol liver disease (ALD) is characterized by intestinal barrier disruption and gut dysbiosis. Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to colitis. We aimed to test the hypothesis that intestinal ELF4 plays a critical role in
Autor:
Ming Kuang, Xuemei Wei, Luoying Chen, Qirui Guo, Yingchi Zhao, Xiu-hong Yang, Lili Cao, Yujie Luo, Xiangxi Wang, Junhong Li, Huawei Xia, Chuan Qin, Fuping You, Linlin Bao, Jiangning Liu, Zeming Zhang, Wei Deng, Nan Wang, Ran Gao, Hua Zhu, Xuefei Guo, Jingxuan Chen, Xiao Wang
Publikováno v:
Cell Host & Microbe
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, the unique signature of early immun
Autor:
Leilei Wang, Duomeng Yang, Tingting Geng, Jesse Hwang, Penghua Wang, Long Yang, Shu Zhu, Harshada Ketkar, Fuping You, Tao Lin, Richard A. Flavell, Erol Fikrig, Jinzhu Ma, Gong Cheng, Jianfeng Dai, Guang Yang, Anthony T. Vella, Yanlin Wang
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Macrophage scavenger receptor 1 (MSR1) mediates the endocytosis of modified low-density lipoproteins and plays an important antiviral role. However, the molecular mechanism underlying MSR1 antiviral actions remains elusive. We report that MSR1 activa
Autor:
Xuehui Zhang, Yujie Luo, Zhinan Yin, Jianlei Hao, Zhe Zhou, Xuhui Yan, Tong Liu, Xiao Wang, Yingchi Zhao, Fuping You, Lu Li, Hongqiang Du, Xuemei Wei, Yunfei Li, Ping Yin, Ling Liang, Luoying Chen, Zeming Zhang, Xuliang Deng, Lili Cao, Jingxuan Chen, Guang Yang, Tongtong Liu
Publikováno v:
Cell Reports. 38:110373
mRNA m6A modification is involved in modulation of immune responses. However, its function in antiviral immunity is controversial, and how immune responses regulate m6A modification remains unknown. We here found TBK1, a key kinase of antiviral pathw
Publikováno v:
Viruses; Volume 13; Issue 12; Pages: 2383
Viruses, Vol 13, Iss 2383, p 2383 (2021)
Viruses
Viruses, Vol 13, Iss 2383, p 2383 (2021)
Viruses
Murine hepatitis virus strain A59 (MHV-A59) was shown to induce pyroptosis, apoptosis, and necroptosis of infected cells, especially in the murine macrophages. However, whether ferroptosis, a recently identified form of lytic cell death, was involved
Autor:
Xiang Gao, Yunfei Li, Hongqiang Du, Chunxia Jing, Xiaohong Ye, Peng Li, Shengde Liu, Meiling Ou, Fuping You, Feng Shao, Guang Yang, Lili Cao, Siji Li, Baohuan Zhang, Yingchi Zhao, Penghua Wang, Peiyan Wang
Toxoplasma gondii is an important neurotropic pathogen that establishes latent infections in humans that can cause toxoplasmosis in immunocompromised individuals. It replicates inside host cells and has developed several strategies to manipulate host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289775e2fcac04c3781017c8381babce
https://europepmc.org/articles/PMC6851339/
https://europepmc.org/articles/PMC6851339/
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0200385 (2018)
PLoS ONE, Vol 13, Iss 8, p e0200385 (2018)
The innate immune system plays a critical role in the initial antiviral response. However, the timing and duration of these responses must be tightly regulated during infection to ensure appropriate immune cell activation and anti-viral defenses. Her
Autor:
Yang O. Zhao, Ruth R. Montgomery, Rongtuan Lin, Feng Qian, Long Yang, Akiko Iwasaki, Richard E. Sutton, Erol Fikrig, Guang Yang, Wendy E. Walker, Fuping You, Penghua Wang
Publikováno v:
Nature immunology. 14(12)
Induction of type I interferon is a central event of innate immunity, essential for host defense. Here we report that the transcription factor ELF4 is induced by type I interferon and upregulates interferon expression in a feed-forward loop. ELF4 def