Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vivien R. Sutton"'
Autor:
Kate H. Gartlan, Slavica Vuckovic, Karshing Chang, Glen M. Boyle, Vivien R. Sutton, Mark J. Smyth, Melody Cheong, Ping Zhang, Motoko Koyama, Kelli P. A. MacDonald, José Paulo Martins, Christopher E. Andoniou, Joseph A. Trapani, Geoffrey R. Hill, Antiopi Varelias, Greg Kelly, Kate A. Markey, Rachel D. Kuns, Siok-Keen Tey, Mariapia A. Degli-Esposti, Jason Sang Hun Lee, Christian R. Engwerda
Publikováno v:
Cancer Immunology Research. 8:1085-1098
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure respo
Autor:
Dale, Christiansen, Effie, Mouhtouris, Russell, Hodgson, Vivien R, Sutton, Joseph A, Trapani, Francesco L, Ierino, Mauro S, Sandrin
Publikováno v:
Transplant international : official journal of the European Society for Organ TransplantationReferences. 32(11)
We have previously reported that ICOS-Ig expressed locally by a PIEC xenograft induces a perigraft cellular accumulation of CD4
Autor:
Joseph A. Trapani, Kevin Y. T. Thia, David M. Tarlinton, Vivien R. Sutton, Axel Kallies, Gabrielle T. Belz, Edwin D. Hawkins, Magdalena Hagn
Publikováno v:
The Journal of Immunology. 188:3886-3892
Recently, it has been reported that human B cells express and secrete the cytotoxic protease granzyme B (GrB) after stimulation with IL-21 and BCR cross-linking. To date, there are few clues on the function of GrB in B cell biology. As experimental t
Autor:
Nigel J. Waterhouse, Karin A Sedelies, Arno Müllbacher, Kylie A. Browne, Aulikki Koskinen, Vivien R. Sutton, Desiree A Anthony, Annette Ciccone, Joseph A. Trapani
Publikováno v:
The Journal of Cell Biology
Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C–null mice are therefore proposed to totally lack granzyme B activi
Autor:
Phillip I. Bird, Marguerite S. Buzza, Claire E Hirst, Joseph A. Trapani, Kate L Loveland, Vivien R. Sutton
Publikováno v:
Monash University
Granzyme B (graB) plays a pivotal role in cytotoxic lymphocyte granule-mediated apoptosis through cleavage of intracellular proteins in target cells. Proteinase inhibitor-9 (PI-9) is a potent inhibitor of graB and is highly expressed in cytotoxic lym
Autor:
Christoph Peters, Vivien R. Sutton, Phillip I. Bird, Joseph A. Trapani, Thomas Reinheckel, Michael E. D'Angelo
The serine protease granzyme B (GrB) is the most potent proapoptotic cytotoxin of the granule exocytosis pathway of cytotoxic lymphocytes. GrB is synthesized as a zymogen (proGrB) and activated in cytotoxic granules by the lysosomal cysteine protease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5c4b08d42e3a98d36eac9ce5fa7b2c
https://europepmc.org/articles/PMC2898313/
https://europepmc.org/articles/PMC2898313/
Autor:
Joseph A. Trapani, Mauro S. Sandrin, Christopher J. Froelich, Vivien R. Sutton, Kylie A. Browne, Yu Qin Li, Kevin Y. T. Thia, David A. Jans
Publikováno v:
The Journal of Cell Biology
The 280-kD cation-independent mannose-6-phosphate receptor (MPR) has been shown to play a role in endocytic uptake of granzyme B, since target cells overexpressing MPR have an increased sensitivity to granzyme B–mediated apoptosis. On this basis, i