Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Justin Komguep Nono"'
Publikováno v:
Journal of Leukocyte Biology
Development of IL-4 receptor alpha (IL-4Rα)-dependent cellular immunity regulates host protection against acute schistosomiasis. In this study, we investigated the importance of IL-4Rα-expressing CD11c+ cells in driving the development of optimal c
Autor:
Thabo Mpotje, Daigen Xu, Thomas Spangenberg, Frank Brombacher, Kai Fu, Justin Komguep Nono, Lerato Hlaka, Paballo Mosala, Severin Donald Kamdem, Nada Abdel Aziz, Georgianna Varrone
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive op
Autor:
Keisha S De Gouveia, Jacqueline S. Womersley, Ousman Tamgue, Tiroyaone M Brombacher, Nokuthula Makena, Frank Brombacher, Matthew Darby, Justin Komguep Nono
Publikováno v:
The Journal of Immunology. 198:2681-2688
The role of proinflammatory cytokines in cognitive function has been investigated with both beneficial and possible detrimental effects, depending on the cytokine. More recently, the type 2 IL-4 has been demonstrated to play a role in cognition. In t
Autor:
Hlumani Ndlovu, Justin Komguep Nono, Nada Abdel Aziz, Natalie Eva Nieuwenhuizen, Frank Brombacher
Publikováno v:
Frontiers in immunology
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Schistosomiasis (bilharzia) is a parasitic helminth disease that can cause severe inflammatory pathology leading to organ damage in humans. Failure of the host to regulate egg-driven granulomatous inflammation causes host morbidity during chronic inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55df9bea8429d58422839123059b4a48
https://hdl.handle.net/21.11116/0000-0004-0172-A21.11116/0000-0004-0174-8
https://hdl.handle.net/21.11116/0000-0004-0172-A21.11116/0000-0004-0174-8
Publikováno v:
PLoS Biology
PLoS Biology, Vol 16, Iss 10, p e2005850 (2018)
PLoS Biology, Vol 16, Iss 10, p e2005850 (2018)
Forkhead box P3 (Foxp3+) regulatory T (Treg)-cell function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. In vivo, interleukin-4 (IL-4)-mediated signaling via IL-4 receptor alpha (IL-4Rα) mediates T
Autor:
Suraj P. Parihar, Mélanie Revaz-Breton, Frank Brombacher, Ramona Hurdayal, Hlumani Ndlovu, Justin Komguep Nono, Melissa Govender
Interleukin-4 (IL-4)–induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite Leishmania major, while conferring immunity to the intestinal trematode Schistosoma mansoni. Here, we report that abrogation of IL-4 receptor alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c5772aab92fb53f74cb7ee01aa553d
https://europepmc.org/articles/PMC5635893/
https://europepmc.org/articles/PMC5635893/
Autor:
Clemens Grimm, Jyotishman Veepaschit, Jeferson Camargo de Lima, Karina Rodrigues Lorenzatto, Karina Mariante Monteiro, Henrique Bunselmeyer Ferreira, Manfred B. Lutz, Justin Komguep Nono, Klaus Brehm, Thomas D. Mueller, Gabriela Hrčková, Emilia Vendelova
Publikováno v:
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005061 (2016)
PLOS Neglected Tropical Diseases
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005061 (2016)
PLOS Neglected Tropical Diseases
Accumulating evidences have assigned a central role to parasite-derived proteins in immunomodulation. Here, we report on the proteomic identification and characterization of immunomodulatory excretory-secretory (ES) products from the metacestode larv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8a01148e0683743a357aec5c0805f4