Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Zhijian Huang"'
Autor:
Zhourui, Ma, Shizhong, Cai, Qianwei, Xiong, Wei, Liu, Hongliang, Xia, Zhenhong, Zhu, Zhijian, Huang, Xiangming, Yan, Qian, Wang
Publikováno v:
Apoptosis. 27:80-89
Glioblastoma multiforme (GBM) has been characterized by the high incidence, therapy tolerance and relapse. The molecular events controlling GBM resistant to chemotherapy temozolomide (TMZ) remain to be elusive. Here, we identified WNT signaling was a
Autor:
Wei Tang, Weina Chai, Donglin Du, Yongzhi Xia, Yifan Wu, Li Jiang, Chongjie Cheng, Zongduo Guo, Xiaochuan Sun, Zhijian Huang, Jianjun Zhong
Publikováno v:
Oxidative Medicine and Cellular Longevity.
We previously discovered that traumatic brain injury (TBI) induces significant perturbations in long noncoding RNA (lncRNA) levels in the mouse cerebral cortex, and lncRNA-AK046375 is one of the most significantly changed lncRNAs after TBI. lncRNA-AK
Autor:
Jianhua Peng, Zhijian Huang, Cheng Yin, Yue Wu, Jianjun Zhong, Li Jiang, Chongjie Cheng, Xiaochuan Sun, Yong Jiang, Fang Cao, Zongduo Guo
Publikováno v:
CNS Neuroscience & Therapeutics
Introduction Axonal injury results in long‐term neurological deficits in traumatic brain injury (TBI) patients. Apolipoprotein E (ApoE) has been reported to activate intracellular adaptor protein Disabled‐1 (Dab1) phosphorylation via its interact
Publikováno v:
BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-6 (2018)
BMC Pulmonary Medicine
BMC Pulmonary Medicine
Background Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an important role in hyperoxia-i
Autor:
Zhaosi Zhang, Xiaochuan Sun, Zhijian Huang, Chongjie Cheng, Jingchuan Wu, Liu Liu, Hui Li, Junchi He, Li Jiang, Zongduo Guo, Yue Wu, Jianjun Zhong, Hongrong Zhang, Lingjun Qi, Han Liu
Publikováno v:
Neurobiology of Disease, Vol 117, Iss, Pp 114-124 (2018)
Traumatic brain injury (TBI) causes a high rate of mortality and disability worldwide, and there exists almost none effective drugs to protect against TBI. Neurotoxicity occurring after TBI can be derived from microglia and astrocytes, and causes neu
Autor:
Yike Huang, Zhaosi Zhang, Xiaochuan Sun, Zhijian Huang, Zongduo Guo, Liu Liu, Li Jiang, Shaoqiu Jiang, Chongjie Cheng, Jianjun Zhong, Jingchuan Wu, Han Liu, Junchi He, Chao Zhou
Publikováno v:
Experimental neurology. 334
Traumatic brain injury (TBI) has been regarded as one of the leading cause of injury-related death and disability. White matter injury after TBI is characterized by axon damage and demyelination, resulting in neural network impairment and neurologica
Publikováno v:
Journal of Alzheimer's Disease. 64:943-955
Background Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Diosgenin is a natural steroid saponin which was shown to play a beneficial role in Alzheimer's disease. Objecti
Autor:
Christina Benda, David P. Ibañez, Zhongzhou Yang, Qiang Zhuang, Micky D. Tortorella, Mazid Md. Abdul, Jiayu Chen, Andrew P. Hutchins, Meng Zhang, Jianguo Zhou, Yan Xu, Xichen Bao, Hui Zhang, Shaorong Gao, Yinghua Huang, Baoming Qin, Zhijian Huang, Jiayin Yang, Xiuling Fu, Ping Liu, Yulin Liu, Xiangpeng Guo, Bushra Mirza, Wenjuan Li, Xiaofen Zhong, Carl Ward, Tanveer Ahmed, Zhiwei Luo, Shahzina Kanwal, Wenxia Fan, Xihua Zhu, Miguel A. Esteban, Muhammad Jadoon Khan, Hung-Fat Tse, Dehao Huang
Publikováno v:
Nature Cell Biology. 20:400-412
Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstra
Autor:
Yue Wu, Liu Liu, Rui Xu, Zhaosi Zhang, Han Liu, Xiaochuan Sun, Zongduo Guo, Wei-na Chai, Hongrong Zhang, Junchi He, Chongjie Cheng, Li Jiang, Zhijian Huang, Gang Huo, Jianjun Zhong
Publikováno v:
International Journal of Medical Sciences
Background: As a major antioxidant in serum, uric acid (UA) was once considered only as the leading cause of gout; however, recent studies have validated its neuroprotective role in ischemic stroke. Because the potential protective effects of UA in t
Autor:
Andrew P. Hutchins, David P. Ibañez, Liu Yuqing, Wing-Hon Lai, Rui Wei, Shuhan Chen, Wenxia Fan, Miguel A. Esteban, Chung-Wah Siu, Liangxue Lai, Xichen Bao, Ka-Wing Au, Zhiwei Luo, Guichan Liang, Xueyu Hong, Lai-Hung Cheng, Lai-Yung Wong, Yu Huang, Ting Zhou, Zhijian Huang, Dongye Wang, Hung-Fat Tse, Xiwei Wang, Jiayin Yang, Xiaofen Zhong, Yu Wang, Ping Zhao, Baoming Qin, Li Li, Yingying Li, Xiao Yu Tian
Publikováno v:
Stem Cell Reports, Vol 8, Iss 3, Pp 605-618 (2017)
Stem Cell Reports
Stem Cell Reports
Summary Familial hypercholesterolemia (FH) causes elevation of low-density lipoprotein cholesterol (LDL-C) in blood and carries an increased risk of early-onset cardiovascular disease. A caveat for exploration of new therapies for FH is the lack of a