Zobrazeno 1 - 7
of 7
pro vyhledávání: '"William D. Hastings"'
Autor:
Juliet Williams, Jeffrey A. Engelman, Guizhi Yang, Matthew J. Meyer, Huai Xiang Hao, William D. Hastings, Chen Liu, Tinya Abrams, Silvia Goldoni, Hui Gao, Giordano Caponigro, Peter S. Hammerman, Hongyun Wang, Colleen Kowal, Scott Delach, Alice Loo, Hengyu Lu, Susan Moody, Matthew J. LaMarche, Ye Wang, Karrie Wong, Morvarid Mohseni, Xiamei Zhang
Publikováno v:
Clinical Cancer Research. 27:342-354
Purpose: SHP2 inhibitors offer an appealing and novel approach to inhibit receptor tyrosine kinase (RTK) signaling, which is the oncogenic driver in many tumors or is frequently feedback activated in response to targeted therapies including RTK inhib
Autor:
Jonathan R. Greene, Elena Ivanova, Moataz Noureddine, Luke J. Taus, David Liu, Tyler Teceno, Maria Pinzon-Ortiz, Navin R. Mahadevan, Tran C. Thai, Derek Liu, Andrew Portell, Amir Vajdi, Shunsuke Kitajima, Prafulla C. Gokhale, Paul Kirschmeier, Juan J. Miret, David A. Barbie, Patrick H. Lizotte, Russell W. Jenkins, Cloud P. Paweletz, Kartik Sehgal, Peter S. Hammerman, Christie J. Lau, Carino Gurjao, William D. Hastings, Tetsuo Tani, Silvia Goldoni, Marios Giannakis
Publikováno v:
J Clin Invest
Resistance to oncogene-targeted therapies involves discrete drug-tolerant persister cells, originally discovered through in vitro assays. Whether a similar phenomenon limits efficacy of programmed cell death 1 (PD-1) blockade is poorly understood. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0b912b1501dd2137016a8614b61480
https://europepmc.org/articles/PMC7810472/
https://europepmc.org/articles/PMC7810472/
Publikováno v:
Immunology Letters. 105:90-96
The peritoneal cavity of mice is enriched for B-1 B cells, a lymphocyte subset that differs from conventional B-2 cells phenotypically, functionally, and developmentally. According to current paradigms, all peritoneal B-1 cells express Mac-1 whereas
Autor:
Robert T. Woodland, Robert S. Negm, Laura A. Solt, William D. Hastings, Thomas L. Rothstein, Thomas J. Schneider, Joseph R. Tumang, Thomas P. Colarusso
Publikováno v:
The Journal of Immunology. 168:2712-2719
B cell susceptibility to Fas-mediated apoptosis is regulated in a receptor-specific fashion. CD40 engagement produces marked sensitivity to Fas killing, whereas surface Ig (sIg) engagement blocks Fas signaling for cell death in otherwise sensitive, C
Publikováno v:
European journal of immunology. 36(5)
B-1 and B-2 cells are lymphocyte populations that differ in development, surface marker expression, tissue localization, and function. Though mainly found in the spleen, lymph nodes, and circulation of mice, small numbers of B-2 cells are found in th
Publikováno v:
European journal of immunology. 34(8)
B-1 cells constitute a distinct B cell population with unique phenotypic and functional characteristics. Although the origin of B-1 cells remains controversial, B-1 cells in different locations are generally considered to be part of the same pool. To
Autor:
Laura A. Solt, Kejian Yang, Barbara S. Nikolajczyk, Rachel M. Gerstein, William D. Hastings, Stephen H. Clarke, Thomas L. Rothstein, Gavin M. Fischer
Publikováno v:
Cellular immunology. 213(1)
B-1 cells constitute a distinct B cell subset with characteristic phenotypic and functional features. B-1 cells are highly represented among peritoneal lymphocytes; substantial numbers of B-1 cells are also located within splenic tissue. Here a numbe