Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Takao Shimazoe"'
Autor:
Keisuke Mine, Takehiro Kawashiri, Mizuki Inoue, Daisuke Kobayashi, Kohei Mori, Shiori Hiromoto, Hibiki Kudamatsu, Mayako Uchida, Nobuaki Egashira, Satoru Koyanagi, Shigehiro Ohdo, Takao Shimazoe
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8859
(1) Background: Oxaliplatin is used as first-line chemotherapy not only for colorectal cancer but also for gastric and pancreatic cancers. However, it induces peripheral neuropathy with high frequency as an adverse event, and there is no effective pr
Autor:
Takao Shimazoe, Mayako Uchida, Daisuke Kobayashi, Natsumi Yamanaka, Mizuki Inoue, Takehiro Kawashiri, Shiori Hiromoto, Keisuke Mine
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Scientific Reports
Scientific Reports
Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia (PPE), is a major side effect of capecitabine. Although the pathogenesis of HFS remains unknown, some studies suggested a potential involvement of inflammation in its pathogene
Autor:
Naohiro Iwata, Daisuke Kobayashi, Takehiro Kawashiri, Toshio Kubota, Kotomi Kawano, Yuki Yamamuro, Anna Miyagi, Yuya Deguchi, Takeshi Chijimatsu, Takao Shimazoe
Publikováno v:
Biologicalpharmaceutical bulletin. 45(6)
Nutmeg, a dried seed kernel of a tall evergreen Myristicaceae tree, is widely used as a spice and herbal medicine and is known to have antidepressant-like effects. This study evaluates the mechanisms underlying this antidepressant-like effect and saf
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 3, Pp 291-294 (2019)
Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively a
Autor:
Yoshito Zamami, Takahiro Niimura, Takehiro Kawashiri, Mitsuhiro Goda, Yutaro Naito, Keijo Fukushima, Soichiro Ushio, Fuka Aizawa, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Koji Miyata, Kenshi Takechi, Masayuki Chuma, Toshihiro Koyama, Daisuke Kobayashi, Takao Shimazoe, Hiromichi Fujino, Yuki Izawa-Ishizawa, Keisuke Ishizawa
Publikováno v:
Biomedicine & Pharmacotherapy. 148:112744
Background: Drug repositioning is a cost-effective method to identify novel disease indications for approved drugs; it requires a shorter developmental period than conventional drug discovery methods. We aimed to identify prophylactic drugs for oxali
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Oxaliplatin frequently causes severe peripheral neuropathy as a dose-limiting toxicity. However, this toxicity lacks a strategy for prevention. Cystine/Theanine is a supplement, which includes precursors for the biosynthesis of glutathione. In this s
Autor:
Keisuke Mine, Nobuaki Egashira, Takao Shimazoe, Takehiro Kawashiri, Mayako Uchida, Nao Shigematsu, Daisuke Kobayashi, Shiori Hiromoto, Shiori Shimizu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Oxaliplatin is a platinum-based antineoplastic drug commonly used for treating colorectal, gastric, and pancreatic cancer. However, it frequently causes peripheral neuropathy as dose-limiting toxicity and is lacking a strategy for prevention. Aloglip
Autor:
Yoshinori Itoh, Takao Shimazoe, Ryozo Oishi, Megumu Yoshimura, Nobuaki Egashira, Yoko Ikegami, Takehiro Kawashiri, Takahisa Yano
Publikováno v:
European Journal of Cancer. 45:154-163
Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In
Autor:
Takashi Tsuruo, Chen Jiang, Noriko Koyabu, Mikihiko Naito, Yoshikazu Yonemitsu, Shigenori Watanabe, Takao Shimazoe, Yasufumi Sawada, Hisakazu Ohtani
Publikováno v:
Human Gene Therapy. 14:1181-1191
The gene encoding mouse glial cell-derived neurotrophic factor (mGDNF gene) was transfected into brain capillary endothelial cells (BCECs) with the aim of delivering the gene product extensively into the brain parenchyma by making use of the secretor
Autor:
Akira Kono, Kyoko Miyasaka, Noboru Kitayama, Iwamoto N, Kayoko Tateishi, Yuji Matsuoka, Takao Shimazoe, Akihiro Funakoshi
Publikováno v:
Life Sciences. 54:1571-1578
Circulating molecular forms with pancreastatin (PST)-like immunoreactivity in plasma from normal subjects were examined. An immunoreactive form corresponding to a human PST-like sequence [human chromogranin-A-(250–301)] (hPST-52) and a larger form