Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sumiti Vinayak"'
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
mBio
mBio
Cryptosporidium parvum and Cryptosporidium hominis are leading pathogens responsible for diarrheal disease (cryptosporidiosis) and deaths in infants and children below 5 years of age. There are no effective treatment options and no vaccine for crypto
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2052
Cryptosporidium parvum can be reliably genetically manipulated using CRISPR/Cas9-driven homologous repair coupled to in vivo propagation within immunodeficient mice. Recent modifications have simplified the initial protocol significantly. This chapte
Autor:
Yael Bar-Peled, Caleb J. Studstill, Adam Sateriale, Sumiti Vinayak, Boris Striepen, Mattie C. Pawlowic, Carrie F. Brooks, Michael J. Cipriano
Publikováno v:
Nature
Recent studies into the global causes of severe diarrhoea in young children have identified the protozoan parasite Cryptosporidium as the second most important diarrhoeal pathogen after rotavirus. Diarrhoeal disease is estimated to be responsible for
Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection
Autor:
Erkang Fan, Kayode K. Ojo, Molly C. McCloskey, Sumiti Vinayak, Wesley C. Van Voorhis, Dustin J. Maly, Matthew A. Hulverson, Rama Subba Rao Vidadala, Wenlin Huang, Lynn K. Barrett, Boris Striepen, Ryan Choi, Deborah A. Schaefer, Grant R. Whitman, Samuel L.M. Arnold, Michael W. Riggs
Publikováno v:
The Journal of Infectious Diseases
Summary Physiologically based pharmacokinetic models for bumped kinase inhibitors suggest that in vivo anticryptosporidial efficacy is associated with gastrointestinal concentrations of drug.
There is a substantial need for novel therapeutics to
There is a substantial need for novel therapeutics to
Autor:
Alejandro Castellanos-Gonzalez, Wesley C. Van Voorhis, Lynn K. Barrett, Samuel L.M. Arnold, Sumiti Vinayak, Dana P. Betzer, Michael W. Riggs, Dustin J. Maly, Kasey Rivas, Boris Striepen, Gillian T. Herbert, Kayode K. Ojo, Carrie F. Brooks, Rama Subba Rao Vidadala, Ryan Choi, A. Clinton White, Grant R. Whitman, Deborah A. Schaefer, Hayley Sparks, Matthew A. Hulverson
Publikováno v:
The Journal of infectious diseases. 215(8)
Bumped kinase inhibitors (BKIs) of Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) are leading candidates for treatment of cryptosporidiosis-associated diarrhea. Potential cardiotoxicity related to anti-human ether-a-go-go potassi
Autor:
Thierry T. Diagana, Suresh B. Lakshminarayana, Susan Noh, Francesca Blasco, Carrie F. Brooks, Jennifer A. Zambriski, Laura B. Goodman, Gu Feng, Sumiti Vinayak, Gillian T. Herbert, Peter Gedeck, Lijun Zhang, Jayesh Tandel, Siau H. Lim, Christian G. Noble, F. Joel Leong, Alex Chao, Juergen Wagner, Bin Zou, Boris Striepen, Tracy Sy, Ravinder Reddy Kondreddi, Christophe Bodenreider, Ujjini H. Manjunatha, Ghislain M. C. Bonamy, Adam Sateriale
Publikováno v:
Nature
Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly grave impact on infants and immunocompr