Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Siddhartha Mukherjee"'
Autor:
Marta Galán-Díez, Florence Borot, Abdullah Mahmood Ali, Junfei Zhao, Eva Gil-Iturbe, Xiaochuan Shan, Na Luo, Yongfeng Liu, Xi-Ping Huang, Brygida Bisikirska, Rossella Labella, Irwin Kurland, Bryan L. Roth, Matthias Quick, Siddhartha Mukherjee, Raul Rabadán, Martin Carroll, Azra Raza, Stavroula Kousteni
Publikováno v:
Cancer Discov
Remodeling of the microenvironment by tumor cells can activate pathways that favor cancer growth. Molecular delineation and targeting of such malignant-cell nonautonomous pathways may help overcome resistance to targeted therapies. Herein we leverage
Autor:
David J. Logan, Sanket S. Acharya, David T. Scadden, Francois Mercier, Azeem Sharda, Cherrie Huang, Dongjun Lee, John G. Doench, John N. Hutchinson, Elizabeth W. Scadden, Michael Churchill, Ninib Baryawno, Sudeshna Das, Nick van Gastel, Vionnie W.C. Yu, Dana S'aulis, Stuart L. Schreiber, Shrikanta Chattophadhyay, Julien Cobert, Mark A. Keibler, Lars Bullinger, Vasanthi Viswanathan, David B. Sykes, Gregory Stephanopoulos, William B. Rizzo, Siddhartha Mukherjee, Borja Saez, Rushdia Z. Yusuf
Publikováno v:
Blood
Metabolic alterations in cancer represent convergent effects of oncogenic mutations. We hypothesized that a metabolism-restricted genetic screen, comparing normal primary mouse hematopoietic cells and their malignant counterparts in an ex vivo system
Autor:
Hiroki Kobayashi, Krystyna A. Gieniec, Tamsin R.M. Lannagan, Tongtong Wang, Naoya Asai, Yasuyuki Mizutani, Tadashi Iida, Ryota Ando, Elaine M. Thomas, Akihiro Sakai, Nobumi Suzuki, Mari Ichinose, Josephine A. Wright, Laura Vrbanac, Jia Q. Ng, Jarrad Goyne, Georgette Radford, Matthew J. Lawrence, Tarik Sammour, Yoku Hayakawa, Sonja Klebe, Alice E. Shin, Samuel Asfaha, Mark L. Bettington, Florian Rieder, Nicholas Arpaia, Tal Danino, Lisa M. Butler, Alastair D. Burt, Simon J. Leedham, Anil K. Rustgi, Siddhartha Mukherjee, Masahide Takahashi, Timothy C. Wang, Atsushi Enomoto, Susan L. Woods, Daniel L. Worthley
Publikováno v:
Paediatrics Publications
Gastroenterology
Gastroenterology
Background & Aims: Cancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However, the cellular origins of CAFs remain unknown, making it challenging to therapeut
Publikováno v:
Cancer Res
p53 is a short-lived protein with low basal levels under normal homeostasis conditions. However, upon DNA damage, levels of p53 dramatically increase for its activation. Although robust stabilization of p53 serves as a “trademark” for DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a6f307edb02b79a849aea7cded2e31
https://europepmc.org/articles/PMC8026563/
https://europepmc.org/articles/PMC8026563/
Autor:
Tadashi Lida, Yukihiro Shiraki, Nobumi Suzuki, Daniel L. Worthley, Krystyna A. Gieniec, Hiroki Kobayashi, Tamsin R M Lannagan, Timothy C. Wang, Alastair D. Burt, Tarik Sammour, Yoku Hayakawa, Masahide Takahashi, Jia Q Ng, Josephine A. Wright, Siddhartha Mukherjee, Lisa M. Butler, Atsushi Enomoto, Kay Uehara, Jeff Hasty, Anil K. Rustgi, Davies Gareth, Ian E. Alexander, Ryota Ando, M. Omar Din, Shinji Mii, Naoya Asai, Mari Ichinose, Leszek Lisowski, Yasuyuki Mizutani, Matthew Lawrence, Andrew C.W. Zannettino, Tongtong Wang, Susan L. Woods, Simon J. Leedham, Laura Vrbanac, Akitoshi Hara
Publikováno v:
Gastroenterology. 160(4)
Background & Aims Cancer-associated fibroblasts (CAFs), key constituents of the tumor microenvironment, either promote or restrain tumor growth. Attempts to therapeutically target CAFs have been hampered by our incomplete understanding of these funct
Autor:
A. Trevor Barlowe, Vineeth Sukrithan, Remco Hoogenboezem, Remi Laurence, Jinghang Zhang, Britta Will, Marc H.G.P. Raaijmakers, Mathijs A. Sanders, Amit Verma, Michael G. Kharas, Si Chen, Robert Lopez, Gaurav Choudhary, Nandini Ramachandra, Prafullla Bhagat, Jacqueline Boultwood, A. Mario Marcondes, Iaonnis Mantzaris, Andrea Pellagatti, John M. Greally, Orsolya Giricz, Matthias Bartenstein, Suman Kambhampati, Cecilia Yeung, Peter D. Aplan, Konrad Hochedlinger, Kira Gritsman, Davendra Sohal, Elianna M. Amin, Tushar D. Bhagat, Siddhartha Mukherjee, Patrick Tivnan, H. Joachim Deeg, Dagny Von Ahrens, Ulrich Steidl, Amittha Wickrema, Yiting Yu, Kith Pradhan
Publikováno v:
Cancer Research, 77(18), 4846-4857. American Association for Cancer Research Inc.
The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of the bone marrow stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNM
Autor:
Maria E. Arcila, Friederike Pastore, Ross L. Levine, Stefan Kubicek, Andrei V. Krivtsov, Lennart Bastian, Alan Chramiec, Daniel Tovbin, Abby R. Weinstein, Mithat Gönen, Adriana Rodriguez Gonzalez, Yen K. Lieu, Jacob M. Rowe, Luisa Luciani, Christopher E. Mason, Richard Koche, Omar Abdel-Wahab, Kaitlyn Shank, Justin R. Cross, Siddhartha Mukherjee, Stephen D. Nimer, Benjamin H. Durham, Wolfgang R. Sperr, Abhinita Mohanty, Olga A. Guryanova, Evangelia Loizou, Elodie Pronier, Barbara Spitzer, Scott A. Armstrong, Gregor Hoermann, Francine E. Garrett-Bakelman, Anna Sophia McKenney, Elisabeth Paietta, Martin S. Tallman, Philipp B. Staber, Matthew D. Keller, Ari Melnick, Sharon A. Rivera, Chezi Ganzel
Publikováno v:
Nature Medicine. 22:1488-1495
Although the majority of patients with acute myeloid leukemia (AML) initially respond to chemotherapy, many of them subsequently relapse, and the mechanistic basis for AML persistence following chemotherapy has not been determined. Recurrent somatic
Autor:
Anne Paulien Drenth, Lukas E. Dow, Jinhyuk Bhin, Catrin Lutz, Jos Jonkers, Bjorn Siteur, Katharina Boroviak, David J. Adams, Marieke van de Ven, Emma M Schatoff, Maria Paz Zafra, Ivo J. Huijbers, Linda Henneman, Kim Wong, Stefano Annunziato, Siddhartha Mukherjee, Bas van Gerwen, Lodewyk F. A. Wessels, Timo Eijkman, Eline van der Burg, Renske de Korte-Grimmerink
Publikováno v:
The EMBO journal. 39(5)
Genetically engineered mouse models (GEMMs) of cancer have proven to be of great value for basic and translational research. Although CRISPR-based gene disruption offers a fast-track approach for perturbing gene function and circumvents certain limit
Autor:
Xiaowei Chen, Yagnesh Tailor, Brittany S. Rush, Karan Nagar, Ming Chiu Fung, Michael Churchill, Bernhard W. Renz, Zhengyu Jiang, Siddhartha Mukherjee, Hongshan Wang, Edwin B.C. Wang, Timothy Chu, Timothy C. Wang, Daniel L. Worthley
Publikováno v:
Oncotarget
// Xiaowei Chen 1, 2, 3 , Michael J. Churchill 2 , Karan K. Nagar 1, 2 , Yagnesh H. Tailor 1, 2 , Timothy Chu 1, 2 , Brittany S. Rush 2 , Zhengyu Jiang 1, 2 , Edwin B.C. Wang 1, 2 , Bernhard W. Renz 1, 2 , Hongshan Wang 1, 2 , Ming Chiu Fung 3 , Dani
Autor:
Wanda Setlik, Deborah L. Gumucio, Karan Nagar, James G. Fox, Meenakshi Rao, Jean Phillipe Pradere, Michael Churchill, Yagnesh Tailor, Simon Renders, Sureshkumar Muthupalani, Heon Goo Lee, Nicholas A. Manieri, Mark Glaire, Andrew S. Giraud, Siddhartha Mukherjee, Tracy C. Grikscheit, Stefanie Gross, Richard A. Friedman, Bernhard W. Renz, Francis Y. Lee, Maximilian Reichert, Anil K. Rustgi, Daniel L. Worthley, Yoku Hayakawa, Yiling Si, Aysu Uygur, Abhinav Nair, Jared Carpenter, Samuel Asfaha, Ashley N. Martinez, Xiaowei Chen, Hongshan Wang, Peter A. Sims, Ajay Prakash, Mazen A. Kheirbek, Gerard Karsenty, Jon Michael Caldwell, Katherine D. Walton, Robert F. Schwabe, Alka Kolhe, Trevor A. Graham, Michael D. Gershon, Jocelyn T. Compton, Saqib Nizami, H. Paco Kang, Matthew G. Schwartz, Guangchun Jin, Timothy C. Wang, Daniel E. Levin, C. Benedikt Westphalen, Thaddeus S. Stappenbeck
Publikováno v:
Cell, vol 160, iss 1-2
PMC
Paediatrics Publications
PMC
Paediatrics Publications
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence