Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shuang Wen"'
Autor:
Yingchao Hu, Yuying Jiang, Sheng Li, Xiaoqing Ma, Min Chen, Rui Yang, Shuang Wen, Paul N. Moynagh, Bingwei Wang, Gang Hu, Shuo Yang
Publikováno v:
Hu, Y, Jiang, Y, Li, S, Ma, X, Chen, M, Yang, R, Wen, S, Moynagh, P N, Wang, B, Hu, G & Yang, S 2022, ' The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11 ', Proceedings of the National Academy of Sciences, vol. 119, no. 45, e2210809119 . https://doi.org/10.1073/pnas.2210809119
Inflammatory pathways usually utilize negative feedback regulatory systems to prevent tissue damage arising from excessive inflammatory response. Whether such negative feedback mechanisms exist in inflammasome activation remains unknown. Gasdermin D
Autor:
Hong Zhou, Yinling Li, Shuang Wen, Haitao Wang, Yeqin Sha, Longjun Li, Meiqing Shi, Qiang You, Yue Li, Lixin Liu
Publikováno v:
Theranostics
Rationale: Invariant natural killer T (iNKT) cells and Kupffer cells represent major hepatic populations of innate immune cells. However, their roles in steatohepatitis remain poorly understood. To elucidate their functions in steatohepatitis develop
Autor:
Bicheng Wang, Zhilian Rui, Yeqin Sha, Dongyan Shi, Fengfeng Yan, Xu Han, Chenhong Si, Yinling Li, Shuang Wen, Yuning Zhou, Jingming Hu
Publikováno v:
Biological Trace Element Research. 199:2482-2488
Iron is one of the most important trace elements in the body, and its homeostasis is essential to the normal function of the immune system. Complement component C3, which is the converging of three main pathways of complement system activation, plays
Autor:
Weiguo Hu, Haitao Wang, Longjun Li, Yeqin Sha, Liang Sheng, Yinling Li, Hong Zhou, Lianping He, Shuang Wen
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(12)
Complement component C3, mainly synthesized by hepatocytes, acts as the convergence point of three different pathways in activating the complement cascade. Besides its well-established roles in the extracellular milieu, C3 performs various intracellu
Autor:
Muyang Gu, Guo-Ping Shi, Yuzhi Lu, Jingyong Li, Jiao Jiao, Ni Xia, Xiang-Ping Yang, Bingjie Lv, Shaofang Nie, Yu Hu, Dan Li, Shuang Wen, Tingting Tang, Xiang Cheng, Mengyang Liao, Yuhua Liao
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:446-458
Objective— Inflammation occurs during the progression of abdominal aortic aneurysm (AAA). IL (interleukin)-33 is a pleiotropic cytokine with multiple immunomodulatory effects, yet its role in AAA remains unknown. Approach and Results— Immunoblot,
Autor:
Chao, Zhu, Shuang, Wen, Junyong, Li, Hongyu, Meng, Junzhe, Zhang, Kuo, Zhao, Ling, Wang, Yingze, Zhang
Publikováno v:
Drug Design, Development and Therapy
Background Fingolimod (FTY720), a novel immunomodulator, was found to suppress the severity of collagen-induced arthritis (CIA) in mice. However, the potential molecular mechanisms are still unknown, and the effect of FTY720 on the recruitment of imm
Autor:
Jingyong Li, Ni Xia, Dan Li, Shuang Wen, Shirui Qian, Yuzhi Lu, Muyang Gu, Tingting Tang, Jiao Jiao, Bingjie Lv, Shaofang Nie, Desheng Hu, Yuhua Liao, Xiangping Yang, Guoping Shi, Xiang Cheng
Publikováno v:
Advanced Science. 9:2104338
In addition to maintaining immune tolerance, Foxp3
Autor:
Hong Zhou, Shuang Wen, Yeqin Sha, Qiang You, Haitao Wang, Liang Sheng, Lixin Liu, Lianping He, Fengjiao Wu, Jun Zhang, Longjun Li, Meiqing Shi
Publikováno v:
Cell Death Differ
Acetaminophen (APAP) is the leading cause of drug-induced acute liver failure. Sphingosine-1-phosphate (S1P), whose formation is catalyzed by sphingosine kinase (SPHK)-1 or -2, is a bioactive lipid implicated in human health and disease. Here, we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5db4c5664a769e83a637e7519ef2df
https://europepmc.org/articles/PMC7244772/
https://europepmc.org/articles/PMC7244772/
Publikováno v:
Clinical and Experimental Immunology. 190:68-78
Summary Renal fibrosis is the common final manifestation of chronic kidney diseases and usually results in end-stage renal failure. In this study, we evaluated the effect of fingolimod (FTY720), an analogue of sphingosine 1-phosphate (S1P), as a trea
Autor:
Weiqi Shen, Shiyu Yun, Jia Chen, Lan Yang, Zhibian Duan, Wang Zhuo, Shuang Wen, Xin Zhang, Dongdong Zhao, Guo Yurong, Sun Yaogui, Haiping Wu
Publikováno v:
Archives of microbiology. 202(1)
Many kinds of antibiotics have effects on intestinal structure and function. In the current experimental study, we evaluate the effect of oral florfenicol on intestinal barrier in mice. Thirty adult male mice were randomly divided into two groups, th