Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ryo, Ito"'
Autor:
Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai, Hitomi Jin, Hyunmi Choi, Myagmar Tumenjargal, Shiyu Xie, Ji Zhang, Hina Sagae, Yanan Zhao, Rei Yamaguchi, Yu Nomura, Yuichi Shimizu, Kaito Yamada, Satoshi Yasuda, Hiroshi Kimura, Toshiya Tanaka, Youichiro Wada, Tatsuhiko Kodama, Hiroyuki Aburatani, Min-Sheng Zhu, Takeshi Inagaki, Timothy F. Osborne, Takeshi Kawamura, Yasushi Ishihama, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
Nature Communications. 13
Protein kinase A promotes beige adipogenesis downstream from β-adrenergic receptor signaling by phosphorylating proteins, including histone H3 lysine 9 (H3K9) demethylase JMJD1A. To ensure homeostasis, this process needs to be reversible however, th
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes
Autor:
Yuji Owada, Masayuki Kanamori, Kosuke Jozaki, Shuhei Kobayashi, Subrata Kumar Shil, Ryo Zama, Hiroshi Kogo, Ariful Islam, Kazuhiko Igarashi, Hirofumi Miyazaki, Chie Shimamoto-Mitsuyama, Yoshiteru Kagawa, Shin Ichiro Kanno, Banlanjo Abdulaziz Umaru, Shun Sato, Ryo Ito, Teiji Tominaga, Hiroki Shima, Akira Yasui, Kohji Fukunaga, Yui Yamamoto, Takeo Yoshikawa, Norihiro Sugino, Akira Sugawara
Publikováno v:
Molecular Neurobiology
Fatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 regulates the response to extracellular sti
Autor:
Toshiya Tanaka, Aoi Uchida, Takeshi Inagaki, Shogo Yamamoto, Tatsuhiko Kodama, Yoshihiro Matsumura, Ryo Ito, Yohei Abe, Youichiro Wada, Ryo Nakaki, Hiroyuki Aburatani, Koichi Node, Shuichi Tsutsumi, Rei Yamaguchi, Makoto Arai, Hitomi Fujihashi, Hiroki Takahashi, Ji Zhang, Kenta Magoori, Hiroyuki Hirakawa, Takeshi Kawamura, Hiroshi Kimura, Shin Ichi Inoue, Juro Sakai, Chaoran Yang, Ayumu Yajima, Timothy F. Osborne, Ge Yang, Satoshi Ota, Takeshi Yoneshiro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Enhancer activation is essential for cell-type specific gene expression during cellular differentiation, however, how enhancers transition from a hypoacetylated “primed” state to a hyperacetylated-active state is incompletely understood. Here, we
Autor:
Ryo Ito, Hiroki Sakamoto, Koji Miyanishi, Kazuyuki Murase, Akira Sakurada, Masayoshi Kobune, Takahiro Osuga, Masanori Sato, Kohichi Takada, Junji Kato, Shingo Tanaka, Tomohiro Kubo, Kota Hamaguchi, Yusaku Nakabeppu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Non-alcoholic steatohepatitis (NASH)-related HCC is associated with oxidative stress. However, the mechanisms underlying the development of NASH-related HCC is unclear. MUTYH is one of the enzymes that is involved in repair of oxidative DNA damage. T
Publikováno v:
Biochemical and Biophysical Research Communications. 489:21-28
CYP11B2 is a key enzyme involved in the synthesis of the mineralocorticoid aldosterone. CYP11B2 expression in the adrenal glands is controlled by the renin-angiotensin system (RAS), and plays an important role in the maintenance of electrolyte metabo
Autor:
Xiaotong Zhuang, Yoshiya Hosokawa, Michinori Funato, Tomomi Sudo, Nobuya Inagaki, Akira Ohta, Taro Toyoda, Ryo Ito, Kenji Osafune, Chihiro Okada, Satoshi Matsui, Yasushi Kondo, Masahiro Nakamura, Akira Watanabe
Publikováno v:
Diabetologia. 60:1454-1466
Pancreatic beta-like cells generated from human induced pluripotent stem cells (hiPSCs) or human embryonic stem cells (hESCs) offer an appealing donor tissue source. However, differentiation protocols that mainly use growth factors are costly. Theref
Autor:
Taisuke Mochida, Noriko Tsubooka-Yamazoe, Hideyuki Hiyoshi, Hikaru Ueno, Hirokazu Matsumoto, Ryo Ito, Taro Toyoda
Publikováno v:
Diabetes. 69(4)
The host environment is a crucial factor for considering the transplant of stem cell–derived immature pancreatic cells in patients with type 1 diabetes. Here, we investigated the effect of insulin (INS)-deficient diabetes on the fate of immature pa
Autor:
Nobuhiro Nishigaki, Hikaru Ueno, Yasufumi Miyamoto, Hirohisa Miyashita, Koji Takeuchi, Yoshiyuki Tsujihata, Minoru Maruyama, Ryo Ito, Hitomi Ogino, Yusuke Moritoh, Shin-ichi Abe
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222653 (2019)
PLoS ONE
PLoS ONE
GPR40/FFAR1 is a Gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, and mediates insulin and incretin secretion to regulate feeding behavior. Several GPR40 full agonists have been reported to reduce food intake in
Autor:
Hitomi Ogino, Tsuyoshi Maekawa, Masanori Watanabe, Mitsugi Ookawara, Koji Takeuchi, Yusuke Moritoh, Hirohisa Miyashita, Hikaru Ueno, Akihiro Kobayashi, Shin-ichi Abe, Nobuhiro Nishigaki, Tomoki Yoshihara, Yukio Yamada, Yoshiyuki Tsujihata, Ryo Ito, Yasufumi Miyamoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 370(2)
The GPR40/FFA1 receptor is a G-protein-coupled receptor expressed in the pancreatic islets and enteroendocrine cells. Here, we report the pharmacological profiles of (3S)-3-cyclopropyl-3-{2-[(1-{2-[(2,2-dimethylpropyl)(6-methylpyridin-2-yl)carbamoyl]
Autor:
Kiyoshi Takagi, Jun Kanno, Atsushi Yokoyama, Akira Sugawara, Tetsuya Sato, Katsuhide Igarashi, Yasuyuki Ohkawa, Takashi Baba, Ryo Ito, Maky Otsuka, Yurina Shishido, Ken Ichirou Morohashi
Publikováno v:
Journal of Biological Chemistry. 289:18152-18162
Regulation of spatiotemporal gene expression in higher eukaryotic cells is critical for the precise and orderly development of undifferentiated progenitors into committed cell types of the adult. It is well known that dynamic epigenomic regulation (i