Zobrazeno 1 - 6
of 6
pro vyhledávání: '"R. Simeonov"'
Autor:
Sana Patel, Michael T. McManus, Brian J. Laidlaw, Mehrdad Matloubian, Dimitre R. Simeonov, Marlys S. Fassett, Pamela M. Odorizzi, Robin Kageyama, Marisella Panduro, K. Mark Ansel, John D. Gagnon, Kristina Johansson, Lukas T. Jeker, Eric J. Wigton, Alexander Marson, Darryl J. Mar, Margaret E. Feeney, Adam J. Litterman, Shomyseh Sanjabi, Hesham M. Shehata
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2169-2181.e4 (2019)
Cell reports
Cell reports, vol 28, iss 8
Cell reports
Cell reports, vol 28, iss 8
SUMMARY Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide prote
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
Autor:
Youjin V. Lee, Siqi Chen, Zhongmei Li, Eric Shifrut, Dimitre R. Simeonov, Igal Ifergan, Diana C. Hargreaves, Jonathan M. Woo, Jessica T. Cortez, Y Zhang, Alexander Marson, Oren Shaked, Ian A. Vogel, Jeffrey A. Bluestone, Zhaolin Sun, Yuanming Xu, Theodore L. Roth, Frédéric Van Gool, Elena Montauti, Deyu Fang, Josephine Ho, Grace Y. Prator, Jovylyn Gatchalian, Yana Zhang, Bin Zhang
Publikováno v:
Nature
Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumour immunity1. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acqui
Autor:
Andrew May, Youjin V. Lee, Alyssa C. Indart, Jessica T. Cortez, Zhongmei Li, Alice Y. Chan, Jonathan M. Woo, James R. Lupski, Mark S. Anderson, Theodore L. Roth, Claudia M.B. Carvalho, Dimitre R. Simeonov, Alexander Marson, Daniel S. Rokhsar, F. William Buaas, James Zou, Alexander J. Brandt
Publikováno v:
Communications Biology
Communications biology, vol 2, iss 1
Communications Biology, Vol 2, Iss 1, Pp 1-6 (2019)
Communications biology, vol 2, iss 1
Communications Biology, Vol 2, Iss 1, Pp 1-6 (2019)
A persistent concern with CRISPR-Cas9 gene editing has been the potential to generate mutations at off-target genomic sites. While CRISPR-engineering mice to delete a ~360 bp intronic enhancer, here we discovered a founder line that had marked immune
Autor:
Ansuman T. Satpathy, K. Mark Ansel, Nicolas Bray, Jeffrey A. Bluestone, Alice Y. Chan, Graham J. Ray, Dimitre R. Simeonov, Kyle Kai-How Farh, Theodore L. Roth, Zhongmei Li, Michelle L.T. Nguyen, Mark J. Daly, William J. Greenleaf, Kathrin Schumann, Gemma L. Curie, Mark S. Anderson, Ruize Liu, Chun Jimmie Ye, Howard Y. Chang, Alexander Marson, Dmytro Lituiev, Therese Mitros, Nicki Naddaf, Jacob E. Corn, Victoria Tobin, Meena Subramaniam, Maxwell R. Mumbach, Hailiang Huang, Benjamin G. Gowen, Rachel E. Gate, Julia S. Chu, John D. Gagnon, Hong Ma, Frédéric Van Gool, Youjin Lee, Eric Boyer, Jonathan M. Woo, Mandy Boontanrart
Publikováno v:
Nature, vol 549, iss 7670
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues. Systematic mapping of functional enhancers and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bd4330f085a76ad425b15ed30679cd
https://escholarship.org/uc/item/89t84794
https://escholarship.org/uc/item/89t84794
Autor:
Ighovie F. Onojafe, Dimitre R. Simeonov, Jun Zhang, Murray H. Brilliant, Isa Bernardini, Chi-Chao Chan, William A. Gahl, Ramakrishna P. Alur, Yuri V. Sergeev, Monika B. Dolinska, David R. Adams, Brian P. Brooks
Publikováno v:
Journal of Clinical Investigation. 121:3914-3923
Mutation of the tyrosinase gene (TYR) causes oculocutaneous albinism, type 1 (OCA1), a condition characterized by reduced skin and eye melanin pigmentation and by vision loss. The retinal pigment epithelium influences postnatal visual development. Th