Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Motohiro Nishida"'
Autor:
Yasunori Iwata, Yusuke Nakade, Shinji Kitajima, Shiori Yoneda-Nakagawa, Megumi Oshima, Norihiko Sakai, Hisayuki Ogura, Koichi Sato, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Hiroka Yamazaki, Akinori Hara, Miho Shimizu, Kengo Furuichi, Masashi Mita, Kenji Hamase, Tomohiro Tanaka, Motohiro Nishida, Wataru Muramatsu, Hisashi Yamamoto, Shigeyuki Shichino, Satoshi Ueha, Kouji Matsushima, Takashi Wada
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F667-F679
d-Alanine has protective effects on I/R-induced kidney injury. d-Ala inhibits ROS production and improves mitochondrial membrane potential, resulting in reduced TEC necrosis by hypoxic stimulation. The administration of d-Ala protects the tubules fro
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 157(5)
G protein-coupled receptors (GPCRs) play pivotal roles in converting physicochemical stimuli due to environmental changes to intracellular responses. After ligand stimulation, many GPCRs are desensitized and then recycled or degraded through phosphor
Autor:
Kazuhiro, Nishiyama, Akiyuki, Nishimura, Kakeru, Shimoda, Tomohiro, Tanaka, Yuri, Kato, Takahiro, Shibata, Hiroshi, Tanaka, Hitoshi, Kurose, Yasu-Taka, Azuma, Hideshi, Ihara, Yoshito, Kumagai, Takaaki, Akaike, Philip, Eaton, Koji, Uchida, Motohiro, Nishida
Publikováno v:
Science signaling. 15(716)
After ligand stimulation, many G protein–coupled receptors (GPCRs) undergo β-arrestin–dependent desensitization, during which they are internalized and either degraded or recycled to the plasma membrane. Some GPCRs are not subject to this type o
Autor:
Sayaka, Oda, Kazuhiro, Nishiyama, Yuka, Furumoto, Yohei, Yamaguchi, Akiyuki, Nishimura, Xiaokang, Tang, Yuri, Kato, Takuro, Numaga-Tomita, Toshiyuki, Kaneko, Supachoke, Mangmool, Takuya, Kuroda, Reishin, Okubo, Makoto, Sanbo, Masumi, Hirabayashi, Yoji, Sato, Yasuaki, Nakagawa, Koichiro, Kuwahara, Ryu, Nagata, Gentaro, Iribe, Yasuo, Mori, Motohiro, Nishida
Publikováno v:
Nature communications. 13(1)
Baroreflex control of cardiac contraction (positive inotropy) through sympathetic nerve activation is important for cardiocirculatory homeostasis. Transient receptor potential canonical subfamily (TRPC) channels are responsible for α
Autor:
Makoto Suematsu, Kazuhiro Nishiyama, Yoshihiro Izumi, Masatomo Takahashi, Ken Ichi Yamada, Takeshi Bamba, Yuki Sugiura, Motohiro Nishida, Yuta Matsuoka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Although oxidized phosphatidylcholines (oxPCs) play critical roles in numerous pathological events, the type and production sites of endogenous oxPCs remain unknown because of the lack of structural information and dedicated analytical methods. Herei
Autor:
Koji Uchida, Kazuhiro Nishiyama, Yasu-Taka Azuma, Akiyuki Nishimura, Tomohiro Tanaka, Chiemi Toyama, Tomohiro Yamashita, Satoru Koyanagi, Yuko Ibuki, Takuro Numaga-Tomita, Naoya Matsunaga, Yasuyuki Fujimoto, Shigehiro Ohdo, Motohiro Nishida
Publikováno v:
Br J Pharmacol
Background and purpose Doxorubicin is a highly effective anticancer agent but eventually induces cardiotoxicity associated with increased production of ROS. We previously reported that a pathological protein interaction between TRPC3 channels and NAD
Autor:
Koji Uchida, Yuki Kakihana, Motohiro Nishida, Ken Ichi Yamada, Takahiro Shibata, Hideshi Ihara, Akane Yamakage, Kenji Kai
Publikováno v:
Journal of Biological Chemistry. 294:1279-1289
Imidazole-containing dipeptides (IDPs), such as carnosine and anserine, are found exclusively in various animal tissues, especially in the skeletal muscles and nerves. IDPs have antioxidant activity because of their metal-chelating and free radical-s
Publikováno v:
YAKUGAKU ZASSHI. 138:1257-1262
Moderate exercise has been reported to combat several diseases, including cardiovascular diseases and depressants. However, many patients do not have ability to undergo exercise therapy due to aging and severity of the symptoms. Therefore development
Autor:
Kakeru, Shimoda, Akiyuki, Nishimura, Caroline, Sunggip, Tomoya, Ito, Kazuhiro, Nishiyama, Yuri, Kato, Tomohiro, Tanaka, Hidetoshi, Tozaki-Saitoh, Makoto, Tsuda, Motohiro, Nishida
Publikováno v:
Scientific Reports
Cardiac tissue remodeling caused by hemodynamic overload is a major clinical outcome of heart failure. Uridine-responsive purinergic P2Y6 receptor (P2Y6R) contributes to the progression of cardiovascular remodeling in rodents, but it is not known whe
Publikováno v:
Current molecular pharmacology. 14(2)
Background: Transient receptor potential (TRP) channels, especially canonical TRP channel subfamily members 3 (TRPC3) and 6 (TRPC6), have attracted attention as a putative therapeutic target of heart | 1 failure. Moreover, TRPC3 and TRPC6 channels ar