Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mark A. Dawson"'
Autor:
Veerle W. Daniels, Enid Y.N. Lam, Paloma Cejas, Clifford A. Meyer, Omer Gilan, Mark A. Dawson, Raga Vadhi, Ian E. Krop, Xintao Qiu, Bogdan Pasaniuc, Cynthia X. Ma, Len Taing, Klothilda Lim, Henry W. Long, Nikolas Kesten, Matthew J. Ellis, April C. Watt, Claudia Giambartolomei, Charles C. Bell, Rhiannon Coulson, Shom Goel, Eric P. Winer, Keegan Korthauer, Otto Metzger-Filho, Molly J. DeCristo, Jean J. Zhao, Alba Font-Tello, Haley BrinJones, Anthony Letai, Matthew L. Freedman, Ji-Heui Seo, Myles Brown, Joan Montero
Publikováno v:
Nature cancer, vol 2, iss 1
Nat Cancer
Nat Cancer
Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert other effects, influencing cancer cell immunogenicity, apoptotic respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07391ad275d64c17c054e5bd0859ea39
https://escholarship.org/uc/item/0b43x9f8
https://escholarship.org/uc/item/0b43x9f8
Autor:
Katie A, Fennell, Dane, Vassiliadis, Enid Y N, Lam, Luciano G, Martelotto, Jesse J, Balic, Sebastian, Hollizeck, Tom S, Weber, Timothy, Semple, Qing, Wang, Denise C, Miles, Laura, MacPherson, Yih-Chih, Chan, Andrew A, Guirguis, Lev M, Kats, Emily S, Wong, Sarah-Jane, Dawson, Shalin H, Naik, Mark A, Dawson
Publikováno v:
Nature. 601(7891)
All cancers emerge after a period of clonal selection and subsequent clonal expansion. Although the evolutionary principles imparted by genetic intratumour heterogeneity are becoming increasingly clear
Autor:
Melanie de Silva, Stewart D. Nuttall, Chen Fang Weng, Bin Ren, Paul Stupple, Mark A. Dawson, Annabelle Hoegl, Tim Thomas, Kathy Knezevic, Ian P. Street, George S. Vassiliou, Catalina Carrasco-Pozo, Yuqing Yang, Marnie E. Blewitt, Tracy A. Willson, Christopher J. Burns, Kah Lok Chan, Juliana Anokye, Linden J. Gearing, Thomas S. Peat, Janet Newman, Olan Dolezal, Oliver M. Dovey, Regina Surjadi, Miriam S. Butler, Laura MacPherson, Paul Yeh, Vicky M. Avery, Jonathan B. Baell, Enid Y.N. Lam, Yuxin Sun, Anne K. Voss, Nghi H. Nguyen, Ming Zhang, Matthew L. Dennis, Hendrik Falk, Rebecca A. Bilardi, Poh Sim Khoo, Marian L. Burr, Brendon J. Monahan, Miriam M. Yeung, Jarny Choi, Yih-Chih Chan, Chunaram Choudhary, Florian Grebien, Sarah-Jane Dawson, Joy Liu, David J. Leaver
Publikováno v:
MacPherson, L, Anokye, J, Yeung, M M, Lam, E Y N, Chan, Y-C, Weng, C-F, Yeh, P, Knezevic, K, Butler, M S, Hoegl, A, Chan, K-L, Burr, M L, Gearing, L J, Willson, T, Liu, J, Choi, J, Yang, Y, Bilardi, R A, Falk, H, Nghi Nguyen, Stupple, P A, Peat, T S, Zhang, M, De Silva, M, Carrasco-Pozo, C, Avery, V M, Khoo, S, Dolezal, O, Dennis, M L, Nuttall, S, Surjadi, R, Newman, J, Ren, B, Leaver, D J, Sun, Y, Baell, J B, Dovey, O, Vassiliou, G S, Grebien, F, Dawson, S-J, Street, I P, Monahan, B J, Burns, C J, Choudhary, C, Blewitt, M E, Voss, A K, Thomas, T & Dawson, M A 2020, ' HBO1 is required for the maintenance of leukaemia stem cells ', Nature, vol. 577, no. 7789, pp. 266-270 . https://doi.org/10.1038/s41586-019-1835-6
Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3bc6f449feaabadd1fab4f6f8e7cdc
Autor:
Stuart M. Pitson, Jason A. Powell, Jessica A. Beach, Alexander C. Lewis, Anthony Copeland, Gregor Ebert, Mark A. Dawson, Karla C. Fischer, Andrew H. Wei, Natasha Silke, Giovanna Pomilio, John Silke, Jarrod J. Sandow, Kate E. Jarman, Emma Morrish, Elizabeth L. Christie, Ann Lin, Laura MacPherson, David D.L. Bowtell, Donia M Moujalled, Andrew I. Webb, Gabriela Brumatti, Marc Pellegrini, Liana Mackiewicz
Publikováno v:
Blood Adv
The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in clinical trials of acute myeloid leukemia (AML) and certain solid cancers. Despite their promising safety profile, SMs
Autor:
Omer Gilan, Colin M. House, Joseph A. Trapani, Ilia Voskoboinik, Ruby H. P. Law, Imran G House, James C. Whisstock, Mark A. Dawson, Amelia Jean Brennan
Publikováno v:
EMBO reports. 18:1775-1785
Perforin is a highly cytotoxic pore‐forming protein essential for immune surveillance by cytotoxic lymphocytes. Prior to delivery to target cells by exocytosis, perforin is stored in acidic secretory granules where it remains functionally inert. Ho
Autor:
Aoife Ward, Dean Tyler, Sarah-Jane Dawson, Edwin D. Hawkins, Paola Grandi, Dave Lugo, Johanna Vappiani, Richard Gregory, Anna Rutkowska, Tatiana Cañeque, Susan Jackson, Cesar Ramirez Molina, Antje Hienzsch, Anne J. Wagner, Rab K. Prinjha, Mark A. Dawson, Thilo Werner, Neil Stuart Garton, Charles C. Bell, Christopher Roland Wellaway, Omer Gilan, Colin M. House, Margarida Figueiredo, Yih-Chih Chan, Gerard Drewes, Raphaël Rodriguez, Laura MacPherson, Sabine Stolzenburg, Enid Y.N. Lam
Publikováno v:
Science
Are better drugs just a click away? Drugs that show promise in preclinical models often fail in the clinic, in part because of limited information on drug localization within cells and across tissues. In a proof-of-concept study, Tyler et al. applied
Autor:
Luciano G. Martelotto, Mark A. Dawson, Paul Yeh, Jean-Christophe Marine, David L Goode, Charles C. Bell, Christopher R. Vakoc, Brandon E. Kremer, Rab K. Prinjha, Sean M. Grimmond, Enid Y.N. Lam, Olena Barbash, Laura MacPherson, Helai P. Mohammad, Chun Yew Fong, Nathan Pinnawala, Timothy M. Johanson, Katie A Fennell, Aljosja Rogiers, Marian L. Burr, Sarah-Jane Dawson, Florian Rambow, Ryan G. Kruger, Shalin H. Naik, Yih-Chih Chan, Anthony T. Papenfuss, Dane Vassiliadis, Rhys S. Allan, Luis Lara, Junwei Shi, Omer Gilan, Arindam Dhar, Luyi Tian, Natalie Karpinich, Miriam M. Yeung, Dean Tyler
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it is unknown whether stable non-genetic resistance can be overcome. Using single cell RNA-sequencing of paired drug naïv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bad888bb74f93a0f32b447e522aea13
https://lirias.kuleuven.be/handle/123456789/647939
https://lirias.kuleuven.be/handle/123456789/647939
Autor:
Aparna Jayachandran, Rebecca Nightingale, Andrew K. Shiau, Oliver M. Sieber, Panagis Filippakopoulos, Diego Arango, Amardeep S. Dhillon, Beatriz Diez-Dacal, John M. Mariadason, Mark A. Dawson, Timothy C. Gahman, Rui Wu, Hoanh Tran, Toby J. Phesse, Anderly C. Chueh, Lars Tögel
Publikováno v:
Molecular Cancer Therapeutics. 15:1217-1226
Inhibitors of the bromodomain and extraterminal domain (BET) protein family attenuate the proliferation of several tumor cell lines. These effects are mediated, at least in part, through repression of c-MYC. In colorectal cancer, overexpression of c-
Autor:
Margaret A. Goodell, Yun Huang, Mark A. Dawson, Jia Li, Clifford Stephan, Anna Guzman, Lei Guo, Deqiang Sun, Peter J.A. Davies, Yubin Zhou, Tingting Li, Minjung Lee, Hongxiang Zeng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Primary and acquired drug resistance imposes a major threat to achieving optimized clinical outcomes during cancer treatment. Aberrant changes in epigenetic modifications are closely involved in drug resistance of tumor cells. Using BET inhibitor (BE
Autor:
Sergio Martínez Cuesta, Zheng Liu, Zhe Li, Robyn Hardisty, Mario Iurlaro, Guillem Portella, Wendy Dean, Pierre Murat, Dario Beraldi, Mark A. Dawson, Wolf Reik, Julia Spindel, Shankar Balasubramanian, Eun-Ang Raiber
Publikováno v:
Nature chemistry. 10(12)
Nucleosomes are the basic unit of chromatin that help the packaging of genetic material while controlling access to the genetic information. The underlying DNA sequence, together with transcription-associated proteins and chromatin remodelling comple