Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Nathan J. Klingensmith, Katherine T. Fay, David A. Swift, Julia M.R. Bazzano, John D. Lyons, Ching-wen Chen, Mei Meng, Kimberly M. Ramonell, Zhe Liang, Eileen M. Burd, Charles A. Parkos, Mandy L. Ford, Craig M. Coopersmith
Publikováno v:
JCI Insight. 7
Expression of the tight junction-associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A -/- mice have increased gut permeability, yet paradoxical
Autor:
Danya Liu, Mandy L. Ford
Publikováno v:
Am J Transplant
Antagonism of the CD154/CD40 pathway is a highly effective means of inducing long-term graft survival in pre-clinical models. Using a fully allogeneic murine transplant model, we found that CD154 blockade was more effective in prolonging graft surviv
Publikováno v:
Am J Transplant
CTLA-4Ig (belatacept) blocks the CD80/CD86 ligands for both CD28 and CTLA-4; thus, in addition to the intended effect of blocking CD28-mediated costimulation, belatacept also has the unintended effect of blocking CTLA-4-mediated coinhibition. Recentl
Autor:
Mandy L. Ford, Ching-Wen Chen, Kimberly M. Ramonell, Shunsuke Otani, Jerome C. Anyalebechi, Craig M. Coopersmith, Deena B. Chihade, Zhe Liang, Jianfeng Xie, Wenxiao Zhang
Publikováno v:
JCI Insight
TIGIT is a recently identified coinhibitory receptor that is upregulated in the setting of cancer and functionally contributes to the impairment of antitumor immunity. However, its role during sepsis is unknown. Because patients with cancer are 10 ti
Autor:
Ashley A. Miniet, Eileen M. Burd, Craig M. Coopersmith, Zhe Liang, Yini Sun, Mandy L. Ford, Takehiko Oami
Publikováno v:
Shock
Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal h
Autor:
Ching-Wen Chen, Craig M. Coopersmith, Mandy L. Ford, Deena B. Chihade, Wenxiao Zhang, Zhe Liang, Alton B. Farris, John D. Lyons, Eileen M. Burd
Publikováno v:
Shock
Patients with cancer who develop sepsis have a markedly higher mortality than patients who were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference have previously been examined in two preclinical models of cancer fo
Autor:
Nathan J. Klingensmith, Ching-Wen Chen, Katherine T. Fay, Mandy L. Ford, Zhe Liang, Mei Meng, Craig M. Coopersmith, John D. Lyons
Publikováno v:
Shock. 51:88-96
The gut is a continuously renewing organ, with cell proliferation, migration and death occurring rapidly under basal conditions. Since the impact of critical illness on cell movement from crypt base to villus tip is poorly understood, the purpose of
Autor:
Elise R. Breed, Eileen M. Burd, Rudolph L. Gleason, Benyam P. Yoseph, Craig M. Coopersmith, Zhe Liang, Carolyn A. Hilliard, Clayton R. Hunt, Ching-Wen Chen, Luke P. Brewster, Laura Hansen, Mandy L. Ford, Rohit Mittal, Tej K. Pandita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1−/− mice is unremarkable. To determine the impact of HSPB1 in
Autor:
Glenn Michael La Muraglia, Idelberto R. Badell, Emma S. Crichton, Maylene E. Wagener, Susan Zeng, Mandy L. Ford
Publikováno v:
Am J Transplant
Anti-donor antibodies cause immunologic injury in transplantation. CD28 blockade with CTLA-4-Ig has the ability to reduce the incidence of these donor-specific antibodies (DSA), but its mechanism is suboptimal for the inhibition of alloimmunity in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f3dc80ed22866d214e692620daa73b
https://europepmc.org/articles/PMC7665991/
https://europepmc.org/articles/PMC7665991/
Autor:
Yini, Sun, Jianfeng, Xie, Jerome C, Anyalebechi, Ching-Wen, Chen, He, Sun, Ming, Xue, Zhe, Liang, Kristen N, Morrow, Craig M, Coopersmith, Mandy L, Ford
Publikováno v:
J Immunol
Immune dysregulation during sepsis is mediated by an imbalance of T cell costimulatory and coinhibitory signaling. CD28 is downregulated during sepsis and is significantly altered on memory versus naive T cells. Thus, to study the role of CD28 during