Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Kim, W."'
Autor:
Lu, X. H., Cho, D., Hall, H., Rowe, T., Mo, I. P., Sung, H. W., Kim, W. J., Kang, C., Cox, N., Klimov, A., Katz, J. M.
Publikováno v:
Avian Diseases, 2003 Jan 01. 47, 1135-1140.
Externí odkaz:
https://www.jstor.org/stable/1593409
Akademický článek
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Autor:
Jianqing Li, Daniel Smith, John S. Tokarski, Lihong Cheng, John E. Macor, Javed Khan, Adriana Zupa-Fernandez, Anil Thankappan, Chunjian Liu, Charu Chaudhry, David S. Weinstein, Percy H. Carter, Kathleen M. Gillooly, Kim W. McIntyre, Yifan Zhang, Anjaneya Chimalakonda, Joann Strnad, James Lin, James R. Burke, David J. Shuster, Manoj Chiney, Paul A. Elzinga, Max Ruzanov, Louis J. Lombardo, Charles M. Langevine
Publikováno v:
Journal of Medicinal Chemistry. 64:677-694
A search for structurally diversified Tyk2 JH2 ligands from 6 (BMS-986165), a pyridazine carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibitor currently in late development for the treatment of psoriasis, began with a survey of six-membere
Autor:
Miller, Annie L, Fuller-Carter, Paula I, Masarini, Klaudija, Samardzija, Marijana, Carter, Kim W, Rashwan, Rabab, Lim, Xin Ru, Brunet, Alicia A, Chopra, Abha, Ram, Ramesh, Grimm, Christian, Ueffing, Marius, Carvalho, Livia S, Trifunović, Dragana
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(8)
Inherited retinal diseases (IRDs) are a heterogeneous group of blinding disorders, which result in dysfunction or death of the light-sensing cone and rod photoreceptors. Despite individual IRDs (Inherited retinal disease) being rare, collectively, th
Autor:
Lee, Y, Han, NE, Kim, W, Kim, JG, Lee, IB, Choi, SJ, Chun, H, Seo, M, Lee, CJ, Koh, HY, Kim, JH, Baik, JH, Bear, MF, Choi, SY, Yoon, BJ
Publikováno v:
Molecules and Cells
© The Korean Society for Molecular and Cellular Biology. All rights reserved. The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and neg
Autor:
Carolyn A. Weigelt, Sha Li, David Marcoux, Georgia Cornelius, Qihong Zhao, Mary Ellen Cvijic, John E. Macor, Jingwu Duan, Melissa Yarde, Muthalagu Vetrichelvan, David J. Shuster, Qingjie Liu, Richard Rampulla, Kim W. McIntyre, Mary T. Obermeier, Shiuhang Yip, Purnima Khandelwal, Sureshbabu Vishwakrishnan, Anuradha Gupta, Virna Borowski, Peng Li, Kevin Stefanski, Sridharan Ramlingam, Myra Beaudoin-Bertrand, Nageswara Maddala, Sridhar Vanteru, Percy H. Carter, Arvind Mathur, Aberra Fura, Max Ruzanov, John Hynes, Dauh-Rurng Wu, Jinhong Wang, Luisa Salter-Cid, John S. Sack, Cornelius Lyndon A M, Anurag S. Srivastava, Robert J. Cherney, Kumaravel Selvakumar, Mushkin Basha, Arun Kumar Gupta, Douglas G. Batt, Rex Denton, Sukhen Karmakar, Qing Shi, Ananta Karmakar, Naveen Manjunath, Javed Khan, Jenny Xie, Joseph A. Tino, T. G. Murali Dhar
Publikováno v:
Journal of Medicinal Chemistry. 62:9931-9946
RORγt is an important nuclear receptor that regulates the production of several pro-inflammatory cytokines such as IL-17 and IL-22. As a result, RORγt has been identified as a potential target for the treatment of various immunological disorders su
Autor:
Kim W. Carter, Fiona J. Pixley, Amy R. Dwyer, Prue H. Hart, Helen S. Goodridge, Naomi M. Scott, Philip Newsholme, Kevin N. Keane, Simon Ghaly, Terence McGonigle, Eloise L Greenland, Denise Anderson
Publikováno v:
The American Journal of Pathology. 187:2046-2059
A systemic immunosuppression follows UV irradiation of the skin of humans and mice. In this study, dendritic cells (DCs) differentiating from the bone marrow (BM) of UV-irradiated mice had a reduced ability to migrate toward the chemokine (C-C motif)
Autor:
T. Thanga Mariappan, Durga Shiv Prasad, Siva Subramani, Jun Zhu, Ajay Saxena, Wen-Pin Yang, Prasad Krishnamurthy, Julie Carman, Satheesh Kesavan Nair, Dawn K. Stetsko, Kim W. McIntyre, John V. Duncia, Joseph B. Santella, Kamala Venkatesh, Ratika Srivastava, Jignesh Nagar, Shailesh Dudhgaonkar, John Hynes, Sabariya Selvam, Li Fan, Sourabh Ranade, Stefan Ruepp, Xin Li, Deborah A. Holloway, Preethi Karunanithi
Publikováno v:
The Journal of Immunology. 198:1308-1319
The serine/threonine kinase IL-1R–associated kinase (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity against multi
Autor:
Jenny Xie, Sha Li, Adriana Zupa-Fernandez, Celia D’Arienzo, Xiaoxia Yang, Mark D. Cunningham, Moslin Ryan M, Xiadi Zhou, Kim W. McIntyre, Kathleen M. Gillooly, James R. Burke, Joann Strnad, Ian M. Catlett, Charu Chaudhry, Shawn M. Rose, Julie Carman, David S. Weinstein, Elizabeth M. Heimrich, Jinwen Huang, Luisa Salter-Cid, Jian Pang, Stephen T. Wrobleski, Dana Banas, Qihong Zhao, Lihong Cheng, Yifan Zhang, Anjaneya Chimalakonda
Publikováno v:
Science Translational Medicine. 11
TYK2 is a nonreceptor tyrosine kinase involved in adaptive and innate immune responses. A deactivating coding variant has previously been shown to prevent receptor-stimulated activation of this kinase and provides high protection from several common
Autor:
Max Ruzanov, David J. Shuster, Manoj Chiney, Kim W. McIntyre, James R. Burke, Celia D’Arienzo, Nelly Aranibar, Elizabeth M. Heimrich, Louis J. Lombardo, Dianlin Xie, Moslin Ryan M, Joann Strnad, Anjaneya Chimalakonda, Lihong Cheng, James Kempson, Adriana Zupa-Fernandez, Javed Khan, Charu Chaudhry, Huadong Sun, Shuqun Lin, Percy H. Carter, Steven H. Spergel, Christine Huang, Dawn Mulligan, Stephen T. Wrobleski, Kathleen M. Gillooly, Yanlei Zhang, Jeffrey Tredup, David S. Weinstein, Tokarski John S, William J. Pitts, Xiaoxia Yang
Publikováno v:
Journal of medicinal chemistry. 62(20)
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of this kinase family has been a