Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joshua R. Cook"'
Autor:
María Concepción Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, InSug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler
Publikováno v:
Journal of Clinical Investigation, 132(7):146219. AMER SOC CLINICAL INVESTIGATION INC
Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular risk. However, the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d8bf597053f4cee90d703c782a1ab4
http://hdl.handle.net/11568/1137713
http://hdl.handle.net/11568/1137713
Publikováno v:
Diabetes
Hypothalamic neurons expressing agouti-related peptide (AgRP) regulate eating and glucose metabolism. Ablation of FOXO1 in AgRP neurons of mice results in reduced food intake, leanness, improved glucose homeostasis, and increased sensitivity to insul
Autor:
Joshua R. Cook, Robert K. Semple
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:1544-1554
Adiponectin is a highly abundant plasma protein synthesized nearly exclusively in adipose tissue from the ADIPOQ gene. It has excited intense interest because of robust correlation of its circulating levels with indices of insulin resistance (IR) and
Autor:
Fanny Langlet, Christoph Buettner, Daniel Lindén, Kumiko S. Aizawa, Domenico Accili, Ling Wang, Rebecca A. Haeusler, Elke Ericson, Anders Johansson, Joshua R. Cook, Tyrrell Norris
Publikováno v:
Cell. 171:824-835.e18
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively. The tight c
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1779:645-651
Pancreatic Derived Factor (PANDER) is a novel cytokine-like protein dominantly expressed within the endocrine pancreas. Our previous study demonstrated that the PANDER promoter was both tissue-specific and glucose-responsive. Surrounding the PANDER t
Publikováno v:
The Journal of biological chemistry. 290(22)
The development of insulin resistance (IR) in the liver is a key pathophysiologic event in the development of type 2 diabetes. Although insulin loses its ability to suppress glucose production, it largely retains its capacity to drive lipogenesis. Th
Autor:
Roger Gutierrez-Juarez, Joshua R. Cook, Mark A. Febbraio, Kirsten Hartil, Rebecca A. Haeusler, Irwin J. Kurland, Isabel Arrieta-Cruz, Helene L. Kammoun, Domenico Accili, Colette M. Knight, Bhavapriya Vaitheesvaran
Publikováno v:
Nature communications
Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former are low and the latter are exaggerated, posing a pathophysiologic and therapeutic conundrum
Autor:
Jianmei Wu, Claudia E. Robert-Cooperman, Jason R. Carnegie, Camella G. Wilson, Jichun Yang, Robert A. Young, Brant R. Burkhardt, Joshua R. Cook, Bryan A. Wolf
Publikováno v:
Diabetes
OBJECTIVE Pancreatic-derived factor (PANDER, FAM3B) is a pancreatic islet-specific cytokine-like protein that is secreted from β-cells upon glucose stimulation. The biological function of PANDER is unknown, and to address this we generated and chara
Autor:
Metin Guclu, Ayse Serap Yalin, Sazi Imamoglu, Ayşe Serin, Joshua R. Cook, Mehmet Nuri Ozbek, Neslihan Önenli Mungan, N Sema Akalin, Bilgin Yüksel, Stephen O'Rahilly, Keith M. Porter, L. Damla Kotan, Robert K. Semple, Frank Reimann, A. Kemal Topaloglu
PubMedID: 19079066 The timely secretion of gonadal sex steroids is essential for the initiation of puberty, the postpubertal maintenance of secondary sexual characteristics and the normal perinatal development of male external genitalia. Normal gonad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb1155b5a4162caae74bf5a3874ca87
https://europepmc.org/articles/PMC4312696/
https://europepmc.org/articles/PMC4312696/