Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jingwu Xie"'
Autor:
Xiaojing Zhao, Wenjing Yang, Tianming Yu, Yu Yu, Xiufang Cui, Zheng Zhou, Hui Yang, Yanbo Yu, Anthony J. Bilotta, Suxia Yao, Jimin Xu, Jia Zhou, Gregory S. Yochum, Walter A. Koltun, Austin Portolese, Defu Zeng, Jingwu Xie, Iryna V. Pinchuk, Hongjie Zhang, Yingzi Cong
Publikováno v:
Gastroenterology. 164:89-102
Intestinal fibrosis is a significant complication of Crohn's disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood.In this study,
Autor:
E. Gabriela Chiorean, Jingwu Xie, Dongsheng Gu, Beiqin Yu, Jun Wan, Xiaoli Zhang, Yanfei Jia, Yunshan Wang
Publikováno v:
Oncogene
Pancreatic cancer, mostly pancreatic ductal adenocarcinomas (PDAC), is one of the most lethal cancers, with a dismal median survival around 8 months. PDAC is notoriously resistant to chemotherapy. Thus far, numerous attempts using novel targeted ther
Publikováno v:
Molecular Carcinogenesis. 57:1608-1615
Colorectal cancer is a leading cause of cancer-related death worldwide. While early stage colorectal cancer can be removed by surgery, patients with advanced disease are treated by chemotherapy, with 5-Fluorouracil (5-FU) as a main ingredient. Howeve
Autor:
Dongsheng Gu, Xiaoben Liu, Seung Young Lee, Samuel Chen, Bing Song, Jingwu Xie, Shovik Bandyopadhyay, Stephen F. Konieczny, Junjie Li, Ji-Xin Cheng, Timothy L. Ratliff
Publikováno v:
Oncogene
Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumula
Autor:
Jeffrey K. Wickliffe, Dongsheng Gu, Istavan Boldogh, Xiaoli Zhang, Nonggao He, James J. Salazar, Jingwu Xie
Publikováno v:
Journal of Genetics and Genomics. 42:589-596
Lung cancer causes more deaths than breast, colorectal and prostate cancers combined. Despite major advances in targeted therapy in a subset of lung adenocarcinomas, the overall 5-year survival rate for lung cancer worldwide has not significantly cha
Publikováno v:
Oncotarget
Gastric cancer is the third leading cause of cancer-related mortality worldwide. Chemotherapy is frequently used for gastric cancer treatment. Most patients with advanced gastric cancer eventually succumb to the disease despite some patients responde
Publikováno v:
Journal of Biological Chemistry. 287:38356-38366
Activation of the Hedgehog (Hh) pathway is known to drive development of basal cell carcinoma and medulloblastomas and to associate with many other types of cancer, but the exact molecular mechanisms underlying the carcinogenesis process remain elusi
Autor:
Zhong Yin Zhang, Jinmin Miao, Ruo-Yu Zhang, Sheng Zhang, Li-Fan Zeng, Zhi-Hong Yu, Jingwu Xie, Yunpeng Bai, Lan Chen
Publikováno v:
Oncotarget
Melanoma ranks among the most aggressive and deadly human cancers. Although a number of targeted therapies are available, they are effective only in a subset of patients and the emergence of drug resistance often reduces durable responses. Thus there
Publikováno v:
Cellular Signalling. 24:1222-1228
Hedgehog (Hh) signaling, via the key signal transducer Smoothened (SMO) and Gli transcription factors, is essential for embryonic development and carcinogenesis. While the biological relevance of hedgehog signaling to cancer is well established, very
Autor:
Tao Sheng, Xiaoli Zhang, Xingbo Zhao, Miao He, Mala Sinha, Qipeng Fan, Bruce A. Luxon, Jingwu Xie
Publikováno v:
Journal of Biological Chemistry. 285:36570-36576
Hedgehog (Hh) signaling, via the key signal transducer Smoothened (SMO) and Gli transcription factors, is essential for embryonic development and carcinogenesis. At present, the molecular mechanism of Hh signaling-mediated carcinogenesis is not compl