Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jianru Xiao"'
Autor:
Lei Li, Peng Xu, Yongyan Dang, Jianru Xiao, Xiaoshuang Wang, Ying Yu, Lei Yuan, Zhipeng Wu, Qingwei Wang, Chan Jiao, Xiao Gao, Yining Ma, Yelin Wu
Publikováno v:
Journal of Dermatological Science. 102:101-108
Background REGγ acts as a proteasome activating factor mediating proteasome degradation of substrate proteins in an ATP and ubiquitination independent manner and also as an important regulator of cell cycle, proliferation and apoptosis. Hair cycle i
Autor:
Jialu Tu, Haiyang Zhang, Ting Yang, Yun Liu, Solomon Kibreab, Yunpeng Zhang, Liangcai Gao, Robb E. Moses, Bert W. O'Malley, Jianru Xiao, Xiaotao Li
Publikováno v:
Journal of Biological Chemistry. 298:102571
The REGγ-20S proteasome is an ubiquitin- and ATP-independent degradation system, targeting selective substrates, possibly helping to regulate aging. The studies we report here demonstrate that aging-associated REGγ decline predisposes to decreasing
Autor:
Xinghai Yang, Pingting Zhou, Haifeng Wei, Tianrui Chen, Jianru Xiao, Bo Li, Jian Jiao, Xu Kehan, Wei Xu, Wei Wan
Publikováno v:
International Journal of Biological Sciences
Metformin, an ancient drug commonly used for treating type II diabetes, has been associated to anti-cancer capacity in a variety of developing cancers, though the mechanism remains elusive. Here, we aimed to examine the inhibitory effect of metformin
Autor:
Ting Wang, Shaohui He, Hongyu Yu, Haifeng Wei, Jinbo Hu, Quan Huang, Jianru Xiao, Zhitao Han, Wang Zhou, Yanbin Xiao, Lei Li
Publikováno v:
British Journal of Cancer
BackgroundThe extracellular matrix has been critically associated with the tumorigenesis and progression of Ewing sarcoma (ES). However, the regulatory and prognostic roles of tenascin-C (TNC) in ES remain unclear.MethodsTNC expression was examined i
Autor:
Yujie Liu, Ao Leng, Lin Li, Bo Yang, Shihui Shen, Hui Chen, Enhao Zhu, Qiyue Xu, Xiaoyu Ma, Peilin Shi, Yun Liu, Tielong Liu, Lei Li, Kun Li, Dan Zhang, Jianru Xiao
Publikováno v:
Cell deathdisease. 13(3)
Since its first identification in prostate cancers and prostate tissues, transient receptor potential melastatin-subfamily member 8 (TRPM8) is subsequently found to be overexpressed in a wide range of cancers and is shown to be implicated in tumorige
Autor:
Xiaopan Cai, Wei Xu, Jianru Xiao, Xinghai Yang, Cong Jiang, Lei Li, Tianhui Hou, Haifeng Wei, Jialin Li, Tielong Liu
Publikováno v:
Stem Cells. 37:582-592
The tumor-initiating cells (TICs) are a cell population that can initiate tumor occurrence, mediate drug resistance, and give rise to metastasis. FOXD3 is a forkhead box (Fox) transcription factor family that regulates the pluripotency of embryonic s
Autor:
Qiang Zhang, Yiyun Cheng, Gao Xin, Yitong Wang, Song Zhang, Yang Yan, Zhengjie Zhou, Jianru Xiao
Publikováno v:
ACS Applied Materials & Interfaces. 11:160-168
Malignant bone tumor accompanied by tumor-associated osteolysis remains a challenging task in clinical practice. Nanomedicines engineered with bone-targeting ligands, such as alendronate and pamidronate, are developed for targeted delivery of therape
Publikováno v:
ACS Applied Materials & Interfaces. 10:41003-41011
Bortezomib is a boronate proteasome inhibitor widely used as an efficient anticancer drug; however, the clinical use of bortezomib is hampered by its adverse effects such as hematotoxicity and peripheral neuropathy, and low efficacy on solid tumors d
Autor:
Qiang Zhang, Jianru Xiao, Quan Huang, Kaili Lin, Xiao He, Xiaopan Cai, Yitong Wang, Yiwen Li, Hui Chen, Yuan Zou, Yiyun Cheng
Publikováno v:
Biomaterials. 183:10-19
Malignant bone tumors associated with aggressive osteolysis are currently hard to be cured by the clinical strategies. Nevertheless, nanomedicine might provide a promising therapeutic opportunity. Here, we developed a multifunctional melanin-like nan
Autor:
Rong Li, Ning Wang, Qin Qin, Zhiying Yue, Xiwen Xue, Alison Gartland, Jian Luo, Jianru Xiao, Guohong Hu, Geng Chen, Xin Niu, Liang He, Zhenxi Li, Wenhao Jiang, Stefan Siwko, Yi Wang, Fei Yue, Yankun Gao, Zhengfeng Yang, Yi Li, Jingduo Gao, Yi Ding, Yanxi Liu, Ziwei Xu, Zengjin Yuan, Xiang Zhang, Mingyao Liu
Publikováno v:
The Journal of Clinical Investigation
Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how osteoclasts regulate premetastatic niche and bone tropism are largely unknown. In this study, we report that osteoclast precursors (OPs) can