Zobrazeno 21 - 30
of 47
pro vyhledávání: '"Jianru Xiao"'
Publikováno v:
Biochemical and biophysical research communications. 502(3)
SETD2 is a histone methyltransferase that catalyzes the trimethylation of lysine 36 on histone 3. SETD2 is frequently found to be mutated or deleted in a variety of human tumors, whereas the role of SETD2 in oncogenesis of osteosarcoma has never been
Autor:
Zhipeng Wu, Chenglong Zhao, Jinping Huang, Jian Zhao, Yunyun Jin, Liang He, Stefan Siwko, Wen-Wei Qiu, Jian Luo, Jie Tang, Jianru Xiao, Wenjun Li, Peng Sun, Fanhua Wang, Hai-Feng Wei, Mingyao Liu, Zhenxi Li, Xian Wu, Ming Qian
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 34(4)
Osteoporosis is a global bone disease characterized by reduced bone mineral density (BMD) and increased risk of fractures. The risk of developing osteoporosis increases with aging, especially after menopause in women. Discovering the signaling pathwa
Autor:
Xin Gao, Shaohui He, Jian Jiao, Tielong Liu, Bai Guangjian, Yujie Liu, Guanghui Chen, Wei Xu, Liu Weibo, Jianru Xiao, Zhengyu Gao, Xinghai Yang, Haifeng Wei
Publikováno v:
Gene. 665
Background Lung cancer leads to the largest number of cancer-related deaths worldwide and is usually accompanied with metastasis which is the primary cause of those death and correlated with poor prognosis. However, the mechanism of lung cancer metas
Autor:
Qingwei Wang, Robb E. Moses, Wang Zhou, Weicang Wang, Lei Li, Jianru Xiao, Yongyan Dang, Geng Chen, Chan Jiao, Quan Huang, Lei Yuan, Jianhua Yang, Fengyuan Chen, Jie Dai, Xiao Gao, Tong Yu, Xiaotao Li, Junjiang Fu, Long Cui, Pei Zhang
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 24(8)
Purpose: Colorectal cancer is one of the most commonly diagnosed cancers closely associated with inflammation and hyperactive growth. We previously demonstrated a regulatory circuit between the proteasome activator REGγ and NF-kappaB (NF-κB) during
Autor:
Xinghai Yang, Jianru Xiao, Tielong Liu, Zhi’an Liu, Dianwen Song, Zhipeng Wu, Jing Wang, Wangjun Yan, Zhenxi Li, Wang Zhou, Huabin Yin, Ting Wang, Quan Huang, Haifeng Wei
Publikováno v:
Oncotarget
// Ting Wang 1,* , Huabin Yin 1,* , Jing Wang 1,2,* , Zhenxi Li 1 , Haifeng Wei 1 , Zhi’an Liu 2 , Zhipeng Wu 1 , Wangjun Yan 1 , Tielong Liu 1 , Dianwen Song 1 , Xinghai Yang 1 , Quan Huang 1 , Wang Zhou 1 and Jianru Xiao 1 1 Department of Bone Tu
Autor:
Shuang Liu, Qiuhong Zuo, Jiwu Chen, Xiaotao Li, Wanli Zhai, Lin Wu, Lei Ji, Yuanyuan Zhang, Jianru Xiao
Publikováno v:
Free Radical Biology and Medicine. 82:42-49
Elimination of oxidized proteins is important to cells as accumulation of damaged proteins causes cellular dysfunction, disease, and aging. Abundant evidence shows that the 20S proteasome is largely responsible for degradation of oxidative proteins i
Autor:
Naimin Shao, Hui Chen, Lei Li, Yu Wang, Leqin Xu, Zhiqi Hu, Changping Wang, Yiyun Cheng, Jianru Xiao
Publikováno v:
Acta Biomaterialia. 17:115-124
Osteosarcoma is a high-grade malignant bone tumor that usually develops in the teenagers. Despite improvement in therapy, the five-year survival rate is poor for patients not responding to treatment or with metastases. Tumor necrosis factor (TNF) rel
Autor:
Huabin Yin, Dianwen Song, Jianru Xiao, Haiyan Chen, Zhipeng Wu, Jing Wang, Wang Zhou, Mo Cheng, Quan Huang, Wangjun Yan, Tielong Liu, Tong Meng, Wei Wan, Zhenxi Li, Zhengyu Jiang, Wei Xu
Publikováno v:
Biochemical and Biophysical Research Communications. 453:160-165
RunX2 has been identified to crucially regulate the osteolysis in giant cell tumor of bone. MiR-30a is an intronic miRNA identified as tumor suppressor, but little is known about its role in giant tumor cell of bone. In our research, we reported miR-
Autor:
Shuang Liu, Mingyao Liu, Qiuhong Zuo, Caifeng Jia, Qingxiang Lin, Zhengfang Yi, Lei Li, Lin Wu, Shixia Huang, Myra Grace Costello, Lujian Liao, Jiang Liu, Jianru Xiao, Li Lai, Yan Wang, Chad J. Creighton, Xiaotao Li, Junjiang Fu, Honglin Luo, Qingxia Zhou, Jian Liu, Fujun Dai
Publikováno v:
Journal of Molecular and Cellular Cardiology. 72:28-38
The REGγ-proteasome serves as a short-cut for the destruction of certain intact mammalian proteins in the absence of ubiquitin- and ATP. The biological roles of the proteasome activator REGγ are not completely understood. Here we demonstrate that R
Autor:
Hong Pan, Rong Lei, Qifeng Yang, Y. Eugene Chin, Yufeng Wang, Xueqian Zhuang, Gang Li, Guohong Hu, Yibin Kang, Xiaoqi Pan, Jing Hu, Qian Tao, Da Fu, Jianru Xiao, Ning Zhang
Publikováno v:
Journal of Clinical Investigation. 124:1646-1659
Bone metastasis is a frequent complication of breast cancer that is often accelerated by TGF-β signaling; however, little is known about how the TGF-β pathway is regulated during bone metastasis. Here we report that deleted in liver cancer 1 (DLC1)