Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Ryan C. Gimple, Guoxin Zhang, Linjie Zhao, Leo J.Y. Kim, Jia Z. Shen, Cheryl Kim, Briana C. Prager, Xujun Wang, Jean A. Bernatchez, Xiang-Dong Fu, Jeremy N. Rich, Kailin Yang, Jair L. Siqueira-Neto, Deobrat Dixit, Zhixin Qiu, Lukas Chavez, Zhe Zhu, Deguan Lv, Ye Zheng, Denise Hinz, Zhengyu Liang, Charles Spruck, Xiuxing Wang, Chunyu Jin, Qiyuan Yang, Qiulian Wu, Lihua Min, Katherine A. Jones, Zhen Dong, Shruti Bhargava
Publikováno v:
Cancer Discov
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by therapeutic resistance, which is promoted by GBM stem cells (GSC). Here, we interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-de
Autor:
Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Tyler E. Miller, Qiulian Wu, Shira Yomtoubian, Reilly L. Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J. Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N. Rich
Publikováno v:
Science translational medicine. 14(626)
Glioblastomas are universally fatal cancers and contain self-renewing glioblastoma stem cells (GSCs) that initiate tumors. Traditional anticancer drug discovery based on in vitro cultures tends to identify targets with poor therapeutic indices and fa
Autor:
Kei-ichiro Arimoto, Leo J.Y. Kim, Balázs Győrffy, Klaus-Peter Knobeloch, Dong-Er Zhang, Hua Cheng, Christoph Burkart, Xiang-Dong Fu, Jeremy N. Rich, Hu Cang, Jun-Bao Fan, Yu Zhou, Hui-Zhong Xu, Ming Yan, Sayuri Miyauchi, Dan Liu
Publikováno v:
Cancer Discov
Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the I
Autor:
Jinkyu Jung, Amber J. Giles, Orieta Celiku, Wei Zhang, Brian J. Williams, Roger Abounader, Jeremy N. Rich, Mark R. Gilbert, Deric M. Park, Ying Zhang, Hua Song
Publikováno v:
Cancer Research. 79:5218-5232
Cancer cells rely on mitochondrial functions to regulate key survival and death signals. How cancer cells regulate mitochondrial autophagy (mitophagy) in the tumor microenvironment as well as utilize mitophagy as a survival signal is still not well u
Autor:
Shideng Bao, Kui Zhai, Xiaoguang Fang, Jeremy N. Rich, Zhi Huang, Leo J.Y. Kim, Jennifer S. Yu, Alexandru Almasan, Xiaoxia Li, Weiwei Tao, Qiulian Wu, Qian Huang, George R. Stark
Publikováno v:
Science Translational Medicine. 13
Glioblastoma (GBM), a lethal primary brain tumor, contains glioma stem cells (GSCs) that promote malignant progression and therapeutic resistance. SOX2 is a core transcription factor that maintains the properties of stem cells, including GSCs, but me
Autor:
Briana C. Prager, Kristopher Berrett, Jeremy N. Rich, Michael N. Wilkinson, Joshua B. Rubin, Sumithra Sankararaman, Lauren Broestl, Xuhua Chen, Robi D. Mitra, Zongtai Qi, Najla Kfoury, Jason Gertz, Arnav Moudgil
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Consistent sex differences in incidence and outcome have been reported in numerous cancers including brain tumors. GBM, the most common and aggressive primary brain tumor, occurs with higher incidence and shorter survival in males compar
Autor:
Tomoyuki Koga, Jianfang Ning, Jun Ma, Anhua Wu, Clark C. Chen, Beibei Xu, Tao Jiang, Gan You, Megan M. Kaneda, Frank B. Furnari, Judith A. Varner, Kunal S. Patel, Ryan M. Shepard, Jeremy N. Rich, Sanjay Dhawan, Ming Li, Andrew S. Venteicher, Aaron L. Sarver, Jie Li, Hua Zhu, Christopher K. Glass
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 16
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Precision medicine in oncology leverages clinical observations of exceptional response. Toward an understanding of the molecular features that define this response, we applied an integrated, multiplatform analysis of RNA profiles derived from clinica
Autor:
Yiting Cao, Jeremy N. Rich, Mark W. Dewhirst, Joseph M. Eble, Gabi Hanna, Douglas H. Weitzel, Chelsea D. Landon, Hong Yuan, James M. Provenzale, Charleen Yu Chih Nien, Ejung Moon
Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that controls cellular homeostasis. Although its activation benefits normal tissue, HIF-1 activation in tumors is a major risk factor for angiogenesis, therapeutic resistance, and po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fd4eb908afa6e20ffb770100ab5b4b
https://ora.ox.ac.uk/objects/uuid:9719300e-ddcc-407b-8e98-c5c8f139f840
https://ora.ox.ac.uk/objects/uuid:9719300e-ddcc-407b-8e98-c5c8f139f840
Autor:
Davide Bernareggi, Qi Xie, Briana C. Prager, Jiyoung Yun, Luisjesus S. Cruz, Timothy V. Pham, William Kim, Xiqing Lee, Michael Coffey, Cristina Zalfa, Pardis Azmoon, Huang Zhu, Pablo Tamayo, Jeremy N. Rich, Dan S. Kaufman
Publikováno v:
Nature communications, vol 13, iss 1
Natural killer (NK) cells are known to mediate killing of various cancer types, but tumor cells can develop resistance mechanisms to escape NK cell-mediated killing. Here, we use a “two cell type” whole genome CRISPR-Cas9 screening system to disc
Autor:
Jia Z. Shen, Zhixin Qiu, Qiulian Wu, Guoxin Zhang, Rebecca Harris, Dahui Sun, Juha Rantala, William D. Barshop, Linjie Zhao, Deguan Lv, Kwang-Ai Won, James Wohlschlegel, Olle Sangfelt, Heike Laman, Jeremy N. Rich, Charles Spruck
Publikováno v:
Mol Cell
A mesenchymal tumor phenotype associates with immunotherapy resistance, although the mechanism is unclear. Here, we identified FBXO7 as a maintenance regulator of mesenchymal and immune evasion phenotypes of cancer cells. FBXO7 bound and stabilized S