Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Jeffrey M. Peters"'
Autor:
Samuel M. Cohen, Jeffrey M. Peters, Xiaoyang Zhu, Laura J. Billy, Frank J. Gonzalez, Arun Sharma, Takayuki Koga, Shantu Amin, Boo Hyon Kang, Ivan Rusyn, Jennifer E. Foreman, Oksana Kosyk
Publikováno v:
Toxicol Sci
Ppara-null and PPARA-humanized mice are refractory to hepatocarcinogenesis caused by the peroxisome proliferator-activated receptor-α (PPARα) agonist Wy-14,643. However, the duration of these earlier studies was limited to approximately 1 year of t
Autor:
Oksana Kosyk, Jeffrey M. Peters, Takayuki Koga, Xiaoyang Zhu, Ivan Rusyn, Laura J. Billy, Arun Sharma, Frank J. Gonzalez, Shantu Amin, Boo Hyon Kang, Samuel M. Cohen, Jennifer E. Foreman
Publikováno v:
Toxicol Sci
Evidence suggests that species differences exist between rodents and humans in their biological responses to ligand activation of PPARα. Moreover, neonatal/postnatal rodents may be more sensitive to the effects of activating PPARα. Thus, the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00f7064e57c0b78fe038e3698ea74d8
https://europepmc.org/articles/PMC8404993/
https://europepmc.org/articles/PMC8404993/
Autor:
John L. Butenhoff, Shu Ching Chang, Yuan Tian, Robert G. Nichols, Bipin Rimal, Jeffrey M. Peters, Limin Zhang, Philip B. Smith, Emmanuel Hatzakis, Andrew D. Patterson
Publikováno v:
Toxicology
Perfluorooctane sulfonate (PFOS) is a persistent environmental chemical whose biological effects are mediated by multiple mechanisms. Recent evidence suggests that the gut microbiome may be directly impacted by and/or alter the fate and effects of en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9680e17d9534c99d55e7f2d68acb2f3
https://europepmc.org/articles/PMC7032741/
https://europepmc.org/articles/PMC7032741/
The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions
Publikováno v:
Archives of Toxicology. 92:83-119
A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce
Autor:
Elizabeth Ola, Christina Lee, Bokai Zhu, Ashley L. Wagner, Boo Hyon Kang, Frank J. Gonzalez, Michael G. Borland, Jeffrey M. Peters, Prajakta P. Albrecht, Pei-Li Yao, Brooke E. Shannon, Ellen M. Kehres, Amanda M. Pritzlaff, Gavin P. Robertson
Publikováno v:
Toxicological Sciences. 159:436-448
Skin tumorigenesis results from DNA damage, increased inflammation, and evasion of apoptosis. The peroxisome proliferator-activated receptors (PPARs) can modulate these mechanisms in non-melanoma skin cancer. However, limited data exists regarding th
Publikováno v:
Immunology. 150:456-467
The peroxisome proliferator‐activated receptor‐β/δ (PPAR β/δ) is known to have multiple anti‐inflammatory effects, typically observed in endothelial cells, macrophages, T cells and B cells. Despite the fact that mast cells are important med
Autor:
Gayathri Balandaram, Gary H. Perdew, Albert J. Fornace, Takayuki Koga, Frank J. Gonzalez, Iain A. Murray, Maryam Goudarzi, Jeffrey M. Peters, Pei-Li Yao
Publikováno v:
Journal of Biological Chemistry. 291:25255-25263
Alcoholic liver disease is a pathological condition caused by overconsumption of alcohol. Because of the high morbidity and mortality associated with this disease, there remains a need to elucidate the molecular mechanisms underlying its etiology and
Autor:
Jindong Ding, Pei-Li Yao, Mayur Choudhary, Michael E. Boulton, Xiaoping Qi, Goldis Malek, Jeffrey M. Peters
Publikováno v:
Aging (Albany NY)
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a nuclear receptor that regulates differentiation, inflammation, lipid metabolism, extracellular matrix remodeling, and angiogenesis in multiple tissues. These pathways are also central
Publikováno v:
Journal of Biological Chemistry. 290:23416-23431
Ppard(-/-) mice exhibit smaller litter size compared with Ppard(+/+) mice. To determine whether peroxisome proliferator-activated receptor-D (PPARD) could possibly influence this phenotype, the role of PPARD in testicular biology was examined. Atroph
Autor:
Jeffrey M. Peters, Craig B. Marcus, Prasad Krishnan, Michael G. Borland, Weiwei Shan, Christina Lee, Gary H. Perdew, Jyh M. Lin, Frank J. Gonzalez, Moses T. Bility, Prajakta P. Albrecht, Shantu Amin
Publikováno v:
Carcinogenesis. 35:1602-1612
Whether peroxisome proliferator-activated receptor β/δ (PPARβ/δ) reduces skin tumorigenesis by altering aryl hydrocarbon receptor (AHR)-dependent activities was examined. Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P