Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Humberto, Jijon"'
Autor:
Andrew K, Chojnacki, Saranya, Navaneetha Krishnan, Humberto, Jijon, Timothy E, Shutt, Pina, Colarusso, Derek M, McKay
Publikováno v:
Mitochondrion. 68:44-59
Mitochondrial dysfunction as defined by transcriptomic and proteomic analysis of biopsies or ultra-structure in transmission electron microscopy occurs in inflammatory bowel disease (IBD); however, mitochondrial dynamics in IBD have received minimal
Autor:
Nicolas Esquerre, Dominique Bihan, Alana Schick, Yasmin Nasser, Manon Defaye, Fernando A. Vicentini, Lilian Basso, Keith A. Sharkey, Christophe Altier, Simon A. Hirota, Ian A. Lewis, Nina L. Cluny, Humberto Jijon, Markus B. Geuking
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Background & Aims Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressio
Autor:
Graham A D Blyth, Anshu Babbar, Humberto Jijon, Ravi Holani, Derek M. McKay, Morley D. Hollenberg, Eduardo R. Cobo, Fernando Lopes
Publikováno v:
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 12, Iss 1 (2020)
article-version (VoR) Version of Record
Gut Microbes, Vol 12, Iss 1 (2020)
We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in regulating gut inflammatory homeostasis. We determined that cathelicidin synergizes with LPS to facilitate its internalization and signaling via endosomic TLR4 in
Publikováno v:
Journal of Autoimmunity. 87:38-49
It is now clear that previously polarized T cells possess the ability to change their phenotype and repolarize towards different fates. This intrinsic flexibility is commonly referred to as plasticity and is influenced by the cytokine milieu, microbi
Autor:
Aleksander Kostic, Ashwin N. Ananthakrishnan, Carey Ann Gallini Comeau, Sydney Lavoie, Wendy S. Garrett, Humberto Jijon, Kara G. Lassen, Hera Vlamakis, Monia Michaud, Hui Pan, Jonathan N. Glickman, Kara L. Conway, Jonathan M. Dreyfuss, Ramnik J. Xavier, Eunyoung Chun, Jessica K. Lang
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD genetic risk loci drive gut microbiota changes. The Crohn’s disease risk allele ATG16L1 T300
Autor:
Mikael J. Pittet, Lucia Suarez-Lopez, M Parada-Kusz, Oscar E. Diaz, Srustidhar Das, Eduardo J. Villablanca, J De Calisto, Ramnik J. Xavier, Humberto Jijon, Michael B. Yaffe, Yasmine Belkaid, J R Mora
Publikováno v:
Mucosal immunology
PMC
PMC
Retinoic acid (RA), a dietary vitamin A metabolite, is crucial in maintaining intestinal homeostasis. RA acts on intestinal leukocytes to modulate their lineage commitment and function. Although the role of RA has been characterized in immune cells,
Autor:
Aviv Regev, Alex K. Shalek, Deborah T. Hung, Douglas Brown, Nathan Haseley, Ramnik J. Xavier, John J. Trombetta, Roi Avraham, Rahul Satija, Humberto Jijon, Cristina Penaranda
Publikováno v:
PMC
Encounters between immune cells and invading bacteria ultimately determine the course of infection. These interactions are usually measured in populations of cells, masking cell-to-cell variation that may be important for infection outcome. To charac
Autor:
Robert J. Heath, Steven A. Carr, Gordon D. Brown, Gautam Goel, Cisca Wijmenga, Jakob Begun, Jatin M. Vyas, Szu Yu Kuo, Mihai G. Netea, Eduardo J. Villablanca, Lola Fagbami, Aylwin Ng, Ramnik J. Xavier, Humberto Jijon, Marije Oosting, Leo A. B. Joosten, Monica Schenone, Vinod Kumar, Mark J. Daly, Kara G. Lassen, Leigh A. Baxt, Jenny M. Tam
Publikováno v:
Cell Reports, 11, 12, pp. 1905-1918
Cell Reports, 11, 1905-1918
Cell Reports, Vol 11, Iss 12, Pp 1905-1918 (2015)
Cell Reports
Cell reports, 11(12), 1905-1918. CELL PRESS
Cell Reports, 11, 1905-1918
Cell Reports, Vol 11, Iss 12, Pp 1905-1918 (2015)
Cell Reports
Cell reports, 11(12), 1905-1918. CELL PRESS
Summary The polymorphism ATG16L1 T300A, associated with increased risk of Crohn’s disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele remain unknown. Here, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b494e048cdb0f76b866d0c5852c558e
https://hdl.handle.net/2066/153186
https://hdl.handle.net/2066/153186
Publikováno v:
European Journal of Immunology. 35:718-726
Serum amyloid A (SAA) is an acute-phase protein whose levels positively correlate with disease activity in inflammatory bowel diseases. In this study we investigated the impact of SAA on NF-kappaB signaling and proinflammatory gene expression in inte
Autor:
Christian Jobin, Nancy Van Houten Fisher, David A. Brenner, Humberto Jijon, Scott T. Magness, Ned E. Sharpless
Publikováno v:
The Journal of Immunology. 173:1561-1570
NF-kappa B is a family of transcription factors involved in regulating cell death/survival, differentiation, and inflammation. Although the transactivation ability of NF-kappa B has been extensively studied in vitro, limited information is available