Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Gregory P. Adams"'
Autor:
Fei Wu, Pei-Ming Chen, Thomas C. Gardinier, Melik Z. Turker, Aranapakam M. Venkatesan, Vaibhav Patel, Tin Khor, Michelle S. Bradbury, Ulrich B. Wiesner, Gregory P. Adams, Geno Germano, Feng Chen, Kai Ma
Publikováno v:
ACS nano. 16(12)
To address the key challenges in the development of next-generation drug delivery systems (DDS) with desired physicochemical properties to overcome limitations regarding safety, in vivo efficacy, and solid tumor penetration, an ultrasmall folate rece
Autor:
Mathilde Poussin, Alba Rodriguez-Garcia, Matthew K. Robinson, Gregory P. Adams, Prannda Sharma, Alina C. Boesteanu, Daniel J. Powell, Sarah B. Gitto, Fiona Simpkins, Nicholas G. Minutolo, Dalia K. Omran
Publikováno v:
Mol Ther
The prognosis of patients diagnosed with advanced ovarian or endometrial cancer remains poor, and effective therapeutic strategies are limited. The Müllerian inhibiting substance type 2 receptor (MISIIR) is a transforming growth factor β (TGF-β) r
Autor:
Rachelle L. Dillon, Joycelyn Entwistle, Glen C. MacDonald, Shilpa Chooniedass, Jeannick Cizeau, Arjune Premsukh, Gregory P. Adams
Publikováno v:
Journal of Immunotherapy. 39:117-126
The development of antibody drug conjugates has provided enhanced potency to tumor-targeting antibodies by the addition of highly potent payloads. In the case of trastuzumab-DM1 (T-DM1), approved for the treatment of metastatic breast cancer, the add
Autor:
Barbara Burtness, Linara Gabitova, Tetyana V. Bagnyukova, Gregory P. Adams, Kathy Q. Cai, Hanqing Liu, Yan Zhou, Ilya G. Serebriiskii, Anna Sukhanova, Gail E. Herman, Lisa E. Kratz, David Cunningham, Igor Astsaturov, Ranee Mehra, Richard I. Kelley, Diana Restifo, Erica A. Golemis, Andrey Gorin, Brian L. Egleston, Hui Zheng, Louis M. Weiner, Dong-Hua Yang, Anna S. Nikonova, Andres J. Klein-Szanto
Publikováno v:
Cancer Discovery. 3:96-111
Persistent signaling by the oncogenic EGF receptor (EGFR) is a major source of cancer resistance to EGFR targeting. We established that inactivation of 2 sterol biosynthesis pathway genes, SC4MOL (sterol C4-methyl oxidase–like) and its partner, NSD
Autor:
Jiping Zhang, Wayne A. Marasco, Louis M. Weiner, Gregory P. Adams, Matthew K. Robinson, Hyung-Ok Lee, Matthildi Valianou, Stefanie R. Mullins, Heidi H. Simmons, Jonathan D. Cheng
Publikováno v:
The FASEB Journal
Fibroblast activation protein (FAP) is a serine protease selectively expressed on tumor stromal fibroblasts in epithelial carcinomas and is important in cancer growth, adhesion, and metastases. As FAP enzymatic activity is a potent therapeutic target
Autor:
John W. Marks, Walter N. Hittelman, Kim Boland, Chiyi Xiong, Michael G. Rosenblum, Stephen I. Rudnick, Lawrence H. Cheung, Yu Cao, Qian Huang, James D. Marks, Chun Li, Xiaoxia Wen, Gregory P. Adams
Publikováno v:
Molecular Cancer Therapeutics. 11:143-153
Recombinant immunotoxins, consisting of single-chain variable fragments (scFv) genetically fused to polypeptide toxins, represent potentially effective candidates for cancer therapeutics. We evaluated the affinity of various anti-Her2/neu scFv fused
Autor:
John E. McCartney, James S. Huston, Louis M. Weiner, Mei-Sheng Tai, L. L. Houston, Gregory P. Adams, James D. Marks, Walter F. Stafford
Publikováno v:
Clinical Cancer Research. 12:1599-1605
Radiolabeled single-chain Fv (sFv) molecules display highly specific tumor retention in the severe combined immunodeficient (SCID) mouse model; however, the absolute quantity of sFv retained in the tumors is diminished by the rapid renal elimination
Autor:
James D. Marks, Deepa Narayanan, Calvin Shaller, Dinko E. Gonzalez Trotter, Lee P. Adler, Gregory P. Adams, Matthew K. Robinson, Mohan Doss
Publikováno v:
Cancer Research. 65:1471-1478
Positron emission tomography (PET) provides an effective means of both diagnosing/staging several types of cancer and evaluating efficacy of treatment. To date, the only U.S. Food and Drug Administration–approved radiotracer for oncologic PET is 18
Autor:
Ekaterina Dadachova, Calvin Shaller, Eva M. Horak, Heidi H. Simmons, Abohawariat Tesfaye, James D. Marks, Andres J. Klein-Szanto, Louis M. Weiner, Martin W. Brechbiel, Gregory P. Adams
Publikováno v:
Cancer Research. 64:6200-6206
Antitumor diabody molecules are noncovalent single-chain Fv dimers that recapitulate the divalent binding properties of native IgG antibodies. Diabodies are capable of substantial accumulation in tumor xenografts expressing relevant antigens in immun
Autor:
Jamie Eisenberg, John E. McCartney, Michael A. Bookman, Gregory P. Adams, E J Wolf, Walter F. Stafford, Mei-Sheng Tai, L. L. Houston, Louis M. Weiner, James S. Huston
Publikováno v:
Cancer Immunology, Immunotherapy. 40:299-306
Single-chain Fv molecules in monovalent (sFv) and divalent [(sFv')2] forms exhibit highly specific tumor targeting in mice as a result of their small size and rapid systemic clearance. As a consequence, there is a rapid reversal of the sFv blood/tumo