Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Franziska M. Uhl"'
Autor:
Rouven, Hoefflin, Sabine, Harlander, Silvia, Schäfer, Patrick, Metzger, Fengshen, Kuo, Désirée, Schönenberger, Mojca, Adlesic, Asin, Peighambari, Philipp, Seidel, Chia-Yi, Chen, Miguel, Consenza-Contreras, Andreas, Jud, Bernd, Lahrmann, Niels, Grabe, Danijela, Heide, Franziska M, Uhl, Timothy A, Chan, Justus, Duyster, Robert, Zeiser, Christoph, Schell, Mathias, Heikenwalder, Oliver, Schilling, A Ari, Hakimi, Melanie, Boerries, Ian J, Frew
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
Nature Communications
Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription factors. While correlative studies of human ccRCC and functiona
Autor:
Lukas Braun, Erika L. Pearce, Bodo Grimbacher, Annette Schmitt-Graeff, Franziska M. Uhl, Dietmar Pfeifer, Barbara Sauer, Melanie Boerries, Joerg M. Buescher, Enrique de Vega Gomez, Justus Duyster, Geoffroy Andrieux, Stefan F. Martin, Robert Zeiser, Alla Bulashevska, Petya Apostolova, Michele Proietti, Philipp R. Esser, Eileen Haring, Marie Follo
Publikováno v:
Haematologica
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and fa
Autor:
Eileen, Haring, Geoffroy, Andrieux, Franziska M, Uhl, Máté, Krausz, Michele, Proietti, Barbara, Sauer, Philipp R, Esser, Stefan F, Martin, Dietmar, Pfeifer, Annette, Schmitt-Graeff, Justus, Duyster, Natalie, Köhler, Bodo, Grimbacher, Melanie, Boerries, Konrad, Aumann, Robert, Zeiser, Petya, Apostolova
Publikováno v:
Haematologica. 107(7)
Acute graft-versus-host disease (GvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), a potentially curative treatment for leukemia. Endoplasmic reticulum (ER) stress occurs when the protein folding ca
Autor:
Sebastian Halbach, Marina Kreutz, Joy Edwards-Hicks, Melanie Boerries, Justus Duyster, Jörg Büscher, Tobias Madl, Olaf Groß, Sandra Duquesne, David O’Sullivan, Eileen Haring, Wolfgang Melchinger, Gesa Richter, Petya Apostolova, Tilman Brummer, Michael Lübbert, Erika L. Pearce, Franziska M. Uhl, Barbara Sauer, Sophia Chen, Bruce R. Blazar, Geoffroy Andrieux, Robert Zeiser, Annette Schmitt-Graeff, Khalid Shoumariyeh
Publikováno v:
Sci Transl Med
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-γ production.
Autor:
Ramon I, Klein Geltink, Joy, Edwards-Hicks, Petya, Apostolova, David, O'Sullivan, David E, Sanin, Annette E, Patterson, Daniel J, Puleston, Nina A M, Ligthart, Joerg M, Buescher, Katarzyna M, Grzes, Agnieszka M, Kabat, Michal, Stanczak, Jonathan D, Curtis, Fabian, Hässler, Franziska M, Uhl, Mario, Fabri, Robert, Zeiser, Edward J, Pearce, Erika L, Pearce
Publikováno v:
Nature metabolism. 2(8)
CD8
Autor:
Shaima'a, Hamarsheh, Lena, Osswald, Benedikt S, Saller, Susanne, Unger, Donatella, De Feo, Janaki Manoja, Vinnakota, Martina, Konantz, Franziska M, Uhl, Heiko, Becker, Michael, Lübbert, Khalid, Shoumariyeh, Christoph, Schürch, Geoffroy, Andrieux, Nils, Venhoff, Annette, Schmitt-Graeff, Sandra, Duquesne, Dietmar, Pfeifer, Matthew A, Cooper, Claudia, Lengerke, Melanie, Boerries, Justus, Duyster, Charlotte M, Niemeyer, Miriam, Erlacher, Bruce R, Blazar, Burkard, Becher, Olaf, Groß, Tilman, Brummer, Robert, Zeiser
Publikováno v:
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Sebastian Halbach, Julia Huber, Robert Zeiser, Martin Köhler, Franziska M. Uhl, Steffen Koschmieder, Tilman Brummer, Konrad Aumann
Publikováno v:
Leukemia. 30:1942-1945
Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model
Autor:
Franziska M. Uhl, Sandra Braun, Lisa C. Schmitt, Robert Zeiser, Björn Schorch, Martin Köhler, Wolfgang W. A. Schamel, Michael Röring, Katharina Heilmann, Sebastian Herzog, Florian Weinberg, Gina J. Fiala, Thorsten Kaltenbacher, Hassan Jumaa, Sophia Ehrenfeld, Natalie Stickel, Tilman Brummer
Publikováno v:
The EMBO journal. 35(2)
Despite being mutated in cancer and RASopathies, the role of the activation segment (AS) has not been addressed for B-Raf signaling in vivo. Here, we generated a conditional knock-in mouse allowing the expression of the B-Raf(AVKA) mutant in which th