Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Franz M"'
Genetic activation of glucokinase in a minority of pancreatic beta cells causes hypoglycemia in mice
Autor:
Kevin H. Chen, Nicolai Doliba, Catherine L. May, Jeffrey Roman, Alessandro Ustione, Teguru Tembo, Ariel Negron, Sally Radovick, David W. Piston, Benjamin Glaser, Klaus H. Kaestner, Franz M. Matschinsky
Publikováno v:
Life Sci
AIMS: Glucokinase (GK) is expressed in the glucose-sensing cells of the islets of Langerhans and plays a critical role in glucose homeostasis. Here, we tested the hypothesis that genetic actvation of GK in a small subset of β-cells is sufficient to
Autor:
Franz M. Matschinsky, Pan Chen, Nicolai M. Doliba, Chengyang Liu, Ali Naji, Qin Liu, Changhong Li
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1240-1253 (2017)
Molecular Metabolism
Molecular Metabolism
Objectives Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by “glucolipotoxicity.” Previously we have shown that acute treatment of panc
Autor:
Kenneth J. Wilkins, Bryan L. Roth, Jürgen Wess, Yinghong Cui, Lingdi Wang, Luiz Felipe Barella, Diptadip Dattaroy, Franz M. Matschinsky, Klaus H. Kaestner, Jonathan Pham, Nicolai M. Doliba, Lu Zhu, Ute Hochgeschwender
Glucagon, a hormone released from pancreatic alpha-cells, plays a key role in maintaining proper glucose homeostasis and has been implicated in the pathophysiology of diabetes. In vitro studies suggest that intra-islet glucagon can modulate the funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264f925f605acce6cb1302cecbd67c46
https://europepmc.org/articles/PMC6542600/
https://europepmc.org/articles/PMC6542600/
Autor:
Thomas Kislinger, Yang W. Shao, Yasunori Okada, Masayuki Shimoda, Andreas Ludwig, Hartland W. Jackson, Laurie Ailles, Alison Aiken, Rama Khokha, Paul Waterhouse, Franz M. Hess, Jeffrey L. Wrana, Hui Fang, Takashi Ohtsuka, Christina Karamboulas, Simona Principe, Valbona Luga, Sam D. Molyneux
Publikováno v:
Nature Cell Biology. 16:889-901
Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cance
Autor:
Jos Kollert, Tobias Pasqualon, Franz M. Hess, Paul Saftig, Andreas Ludwig, Stella Nyamoya, Stefan Uhlig, Emiel P. C. van der Vorst, Marjo M. P. C. Donners, Henriette Alert, Daniela Dreymueller, Esther Groth, Christian Martin, Jessica Pruessmeyer, Nicole Schwarz
Publikováno v:
Blood, 123(26), 4077-4088. The American Society of Hematology
Inflammation is a key process in various diseases, characterized by leukocyte recruitment to the inflammatory site. This study investigates the role of a disintegrin and a metalloproteinase (ADAM) 10 and ADAM17 for leukocyte migration in vitro and in
Autor:
Franz M. Matschinsky
Publikováno v:
Trends in Pharmacological Sciences. 34:90-99
Results of basic biochemical and physiological research, strongly endorsed by findings in human pathophysiology and genetics, had characterized the glucose phosphorylating enzyme glucokinase as a critical player in normal glucose homeostasis, diabete
Autor:
Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
Publikováno v:
Journal of Medicinal Chemistry. 55:7021-7036
Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology stu
Autor:
Daniela Dreymueller, Franz M. Hess, Keisuke Horiuchi, Andreas Ludwig, Christian Martin, Stefan Uhlig, Tanja Kogel, Jessica Pruessmeyer
Publikováno v:
EMBO Molecular Medicine
Acute lung injury (ALI) is associated with increased vascular permeability, leukocyte recruitment, and pro-inflammatory mediator release. We investigated the role of the metalloproteinase ADAM17 in endotoxin-induced ALI with focus on endothelial ADAM
Autor:
Inigo Ruiz de Azua, Wataru Sakamoto, Mario Rossi, Huiyan Lu, Adrian J. Butcher, Heike Rebholz, Yinghong Cui, Nicolai M. Doliba, Franz M. Matschinsky, Lu Zhu, Luiz Felipe Barella, Andrew B. Tobin, Jürgen Wess
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(49)
G protein-coupled receptors (GPCRs) regulate virtually all physiological functions including the release of insulin from pancreatic β-cells. β-Cell M3 muscarinic receptors (M3Rs) are known to play an essential role in facilitating insulin release a
Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
Publikováno v:
Diabetes
OBJECTIVE The posttranslational regulation of glucokinase (GK) differs in hepatocytes and pancreatic β-cells. We tested the hypothesis that GK mutants that cause maturity-onset diabetes of the young (GK-MODY) show compromised activity and posttransl