Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dawang Zhou"'
Autor:
Shuaifeng Li, Shixun Han, Qi Zhang, Yibing Zhu, Haitao Zhang, Junli Wang, Yang Zhao, Jianhui Zhao, Lin Su, Li Li, Dawang Zhou, Cunqi Ye, Xin-Hua Feng, Tingbo Liang, Bin Zhao
Publikováno v:
Nature Communications. 13
Mitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain contai
Autor:
Qiao Wu, Bo Zhou, Hang-zi Chen, Dawang Zhou, Wei-jia Wang, Kang Cheng, Fu-nan Li, Ru-yue Sun, Yuan-li Ai, Fan-jian Liu, Zhi-hong Jiang, Jia-yuan Zhang, Bao-rui Wang
Publikováno v:
Cell Research
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (α-KG) induces pyroptosis through caspas
Autor:
Zhang Jingfang, Yunzhan Li, Zhenzhen Fan, Zhuang Zhongji, Li Li, Ting Zhang, Dawang Zhou, Sun Xihuan, Xianming Deng, Liu Yan, Fu Gui, Deng Zhou, Jie Jiang, Su-Jie Zhu, Huang Xiaoxing, Yue Lu, Siyang Song, Jianming Zhang, Xuehui Hong, Zhang Baoding, Qiao Wu, Lanfen Chen, Wei Huang, Xin Huang, Cai-Hong Yun, Qiyuan Li, Liang Chen, Lei Gao, Zheng Wang
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 1, Pp n/a-n/a (2022)
EMBO Molecular Medicine
EMBO Molecular Medicine
More than 60% of nonsmall cell lung cancer (NSCLC) patients show a positive response to the first ALK inhibitor, crizotinib, which has been used as the standard treatment for newly diagnosed patients with ALK rearrangement. However, most patients ine
Autor:
Chen-Song Zhang, Bingchang Zhang, Mengqi Li, Xiaoyan Wei, Kai Gong, Zhiyong Li, Xiangyang Yao, Jianfeng Wu, Cixiong Zhang, Mingxia Zhu, Lei Zhang, Xiufeng Sun, Yi-Hong Zhan, Zhengye Jiang, Wenpeng Zhao, Wei Zhong, Xinguo Zhuang, Dawang Zhou, Hai-Long Piao, Sheng-Cai Lin, Zhanxiang Wang
Publikováno v:
Science China. Life sciences. 65(10)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a strong production of inflammatory cytokines such as TNF and IL-6, which underlie the severity of the disease. However,
Autor:
Jinjia Zhang, Yiran Shi, Jing Geng, Weihong Yuan, Ping Wang, Hao Zhao, Dawang Zhou, Bingying Yang, Xianming Deng, Funiu Qin, Lixin Hong, Yujie Sun, Junhong Li, Lanfen Chen, Congying Wu, Changchuan Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR
Autor:
Fei Chen, Dawang Zhou, Jiancheng Ding, Wen Liu, Aicun Li, Lei Zhang, Han You, Zhe Meng, Zhicheng Gong, Ronggui Hu, Yuanpei Li, Jialiang Huang, Qing Li, Jing Ye
Publikováno v:
Advanced Science
Advanced Science, Vol 8, Iss 15, Pp n/a-n/a (2021)
Advanced Science, Vol 8, Iss 15, Pp n/a-n/a (2021)
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST/
Autor:
Yuezhou, Wang, Lei, Zhang, Yanling, Wei, Wei, Huang, Li, Li, An-An, Wu, Anahita, Dastur, Patricia, Greninger, Walter M, Bray, Chen-Song, Zhang, Mengqi, Li, Wenhua, Lian, Zhiyu, Hu, Xiaoyong, Wang, Gang, Liu, Luming, Yao, Jih-Hwa, Guh, Lanfen, Chen, Hong-Rui, Wang, Dawang, Zhou, Sheng-Cai, Lin, Qingyan, Xu, Yuemao, Shen, Jianming, Zhang, Melissa S, Jurica, Cyril H, Benes, Xianming, Deng
Publikováno v:
Cell chemical biology. 27(11)
Multidrug resistance (MDR) in cancer remains a major challenge for the success of chemotherapy. Natural products have been a rich source for the discovery of drugs against MDR cancers. Here, we applied high-throughput cytotoxicity screening of an in-
Autor:
Jie Jiang, Zheng Wang, Li Li, Deng Zhou, Xinrui Wu, Sun Xihuan, Xianming Deng, Yunzhan Li, Ruibao Ren, Fu Gui, Huang Xiaoxing, Hong-Rui Wang, Siyang Song, Shang Han, Jianming Zhang, Zhixiang He, Lanfen Chen, Bo Jiao, Wei Huang, Dawang Zhou, Shunying Li, Qiang Liu, Ting Zhang
Publikováno v:
Cancer Research. 77:175-186
Approximately 80% of breast cancers overexpress the kinase breast tumor kinase (BRK)/protein tyrosine kinase 6, which has various oncogenic roles in breast cancer cell proliferation, survival, and migration. However, BRK inhibitors have yet to be exp
Autor:
Pei-pei Hou, Sheng-fu Wu, Dawang Zhou, Wenxiu Zhao, Jianming Liu, Qiao Wu, Hang-zi Chen, Xiaomin Wang, Li-juan Luo, Lu-ming Yao, Qinghua Chen, Xue-li Bian, Zhi-yuan Zhang, Jia-xin Zhou, Qi-tao Chen
Publikováno v:
Molecular cell. 78(6)
Tumor-derived extracellular vesicles are important mediators of cell-to-cell communication during tumorigenesis. Here, we demonstrated that hepatocellular carcinoma (HCC)-derived ectosomes remodel the tumor microenvironment to facilitate HCC progress
Autor:
Lanfen Chen, Han You, Zengqiang Yuan, Jing Geng, Yiran Shi, Yueyue Linghu, Jau-Song Yu, Ping Wang, Jiahui Gao, Xun Li, Dawang Zhou, Randy L. Johnson, Chen Xiao, Hao Zhao, Bingying Yang, Junhong Li, Xiufeng Sun, Funiu Qin, Xin Chen, Lixin Hong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases