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pro vyhledávání: '"David G. Hoel"'
Autor:
David G, Hoel, Bruce A, Carnes
Publikováno v:
International journal of radiation biology. 93(6)
In this study, the B6CF
Publikováno v:
International Journal of Radiation Biology. 86:300-320
To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution.Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter
Autor:
David G. Hoel
Publikováno v:
Health physics. 108(3)
Radiation cancer risk estimates have been based primarily on the atomic bomb survivor cohorts, which involve an acute exposure. To adjust for lower dose and continuous exposures, a dose and dose rate effectiveness factor (DDREF) is applied to the acu
Publikováno v:
Radiation Research. 166:782-793
Approximately 1800 female CBA/Ca mice were exposed by inhalation at three dose levels to beta particles from (45)Ca-labeled fused aluminosilicate particles (FAP), to alpha particles from (242)Cm-labeled FAP, or to carrier control FAP. Another group o
Autor:
David G. Hoel
Publikováno v:
Annals of the New York Academy of Sciences. 1076:309-317
For more than 15 years the A-bomb survivor studies have shown increased noncancer mortality due to radiation exposures. The most prominent cause of this increase is circulatory disease mortality. Although the estimated relative risk is less than for
Autor:
David G. Hoel, Christopher J. Portier
Publikováno v:
Environmental Health Perspectives
Carcinogenesis data for 315 chemicals were obtained from the National Cancer Institute-National Toxicology Program (NCI-NTP) bioassay programs and were analyzed to examine the shape of carcinogenesis dose-response curves. Tumor site data were more of
Publikováno v:
Risk Analysis. 12:115-121
The use of average qualitative concordance between two bioassay endpoints is considered, with emphasis directed at agreement between rats and mice from results of long-term carcinogenicity studies. It is noted that concordance varies as a function of
Publikováno v:
Radiation research. 160(2)
Exposure, pathology and mortality data for mice, dogs and humans were examined to determine whether accurate interspecies predictions of radiation-induced mortality could be achieved. The analyses revealed that (1) days of life lost per unit dose can
Autor:
David G. Hoel, Walter W. Piegorsch
Publikováno v:
Mutation Research/Reviews in Genetic Toxicology. 196:161-175
Salmonella mutagenic and rodent carcinogenic potencies are calculated for 112 compounds recently studied by the U.S. National Toxicology Program. 28 of the 112 compounds are seen to exhibit simultaneous non-zero mutagenic and carcinogenic potencies.
Autor:
Christopher J. Portier, David G. Hoel
Publikováno v:
Risk Analysis. 7:437-447
The TD50 (or tumorigenic dose rate 50) is a generally accepted measure of the carcinogenic potency of a chemical in a particular strain of animal. This paper discusses error in the estimation of the TD50 caused by intercurrent mortality and error res