Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Daniel T. Meehan"'
Autor:
Jacob, Madison, Kevin, Wilhelm, Daniel T, Meehan, Duane, Delimont, Gina, Samuelson, Dominic, Cosgrove
Publikováno v:
The Journal of pathology. 258(1)
In Alport mice, activation of the endothelin A receptor (ET
Autor:
Brianna Dufek, Edward Doyle, Michael Anne Gratton, Ross Coenen, Daniel T. Meehan, Brendan J Smyth, Jacob Madison, Gina Samuelson, Kevin Wilhelm, Dominic Cosgrove, Grady Phillips, Duane Delimont
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237907 (2020)
PLoS ONE
PLoS ONE
Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracel
Autor:
Grady Phillips, Daniel T. Meehan, Marisa Zallocchi, Michael Anne Gratton, Duane Delimont, Dominic Cosgrove, Brianna Dufek
Publikováno v:
Hearing Research. 341:100-108
Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation
Autor:
Shiguang Liu, Duane Delimont, Brianna Dufek, Michael Anne Gratton, Linda Cheung, Wenping Song, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove
Publikováno v:
Kidney International. 90:300-310
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the subcapillar
Autor:
Grady Phillips, Michael Anne Gratton, Duane Delimont, Deidre A. MacKenna, Gretchen Bain, Dominic Cosgrove, Daniel T. Meehan, Brianna Dufek, Michael Hartnett, Gina Samuelson
Publikováno v:
Kidney Int
Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize
Publikováno v:
The American Journal of Pathology. 183(4):1269-1280
Alport syndrome, hereditary glomerulonephritis with hearing loss, results from mutations in type IV collagen COL4A3, COL4A4, or COL4A5 genes. The mechanism for delayed glomerular disease onset is unknown. Comparative analysis of Alport mice and CD151
Autor:
Greg A. Perry, Stacie O'Brien, Taina Pihlajaniemi, Duane Delimont, Dominic Cosgrove, Hongmin Tu, Daniel T. Meehan, Marisa Zallocchi, Jameel Dennis
Publikováno v:
The American Journal of Pathology. 177:2527-2540
Alport syndrome is a common hereditary basement membrane disorder caused by mutations in the collagen IV α3, α4, or α5 genes that results in progressive glomerular and interstitial renal disease. Interstitial monocytes that accumulate in the renal
Autor:
Dominic Cosgrove, Raghu Kalluri, Aldo Amatucci, Phillip Gotwals, Daniel T. Meehan, Victor E. Kotelianski, Humphrey Gardner, Karen Bovard, Amy Gilroy, Caroline Miller, Kathryn D. Rodgers
Publikováno v:
Scopus-Elsevier
Alport syndrome is a genetic disorder resulting from mutations in type IV collagen genes. The defect results in pathological changes in kidney glomerular and inner-ear basement membranes. In the kidney, progressive glomerulonephritis culminates in tu
Autor:
Raghuram Kalluri, Kathyrn D. Rodgers, Robinlyn Sayers, Dominic Cosgrove, Daniel T. Meehan, Charles F. Shield
Publikováno v:
Kidney International. 56:1662-1673
Role for transforming growth factor-β1 in Alport renal disease progression. Background Alport syndrome results from mutations in either the α3(IV), α4(IV), or α5(IV) collagen genes. The disease is characterized by a progressive glomerulonephritis
Autor:
Dominic Cosgrove, William J. Hunter, James A. Grunkemeyer, Daniel T. Meehan, Jody M. Kornak, Robinlyn Sayers, Gina Samuelson
Publikováno v:
Genes & Development. 10:2981-2992
A mouse model for the autosomal form of Alport syndrome was produced. These mice develop a progressive glomerulonephritis with microhematuria and proteinuria, consistent with the human disease. End-stage renal disease develops at approximately 14 wee